Tonix Pharmaceuticals Expands Preclin→'ical Pipeline with Triple®> Reuptake Inhibitor, TNX-1600, ≥₹for the Treatment of PTSD
Tonix Pharmaceuticals Hol÷®ding Corp., a clinical-stage biophar÷♣maceutical company, annou₽±nced today an exclusive a∞∑greement to in-license a triple reupta '§βke inhibitor (TRI), TNX-1600 (former↔÷↑ly D-578), to treat posttraumatε₽≥'ic stress disorder (PTSD) and potentially≈ δ other central nervous system→₹ (CNS) disorders. The co<δ♠mpound was developed and pharmacologically chσ→∏aracterized by Aloke Du>≥☆tta, Ph.D., professor of Pharmace✔σ∏£utical Sciences at Wayne State Universitγ¥y, with funding from a National In"¥Ω↓stitutes of Health grant (grant number MH084888),ε∑✘ and the patents covering the compound≥π✘&s were licensed to TRIma₩α↔♣ran Pharma, Inc. (TRImaran). The tran✔±±<saction announced to↑₽day is a license agreement with W±÷ayne State and an asset acquisition with T§★♣RImaran.“We are exci♦€<αted to expand our pipeline and €↑ are looking forward to developing TNX-1600 ≠∏♦ as a potential treatment for PTSD,” sδ™ aid Seth Lederman, M.D., Tonix©γ×'s President and Chief Executive Of✔λficer. “We plan to utilize our ∞♠✘®clinical experience in PTSD to e↓★×valuate the therapeutic benefit of TNX-1600. PTS→ ♣✔D is a heterogeneous condition, so we belie∑≠≈φve different PTSD patients may respond to d≈ ifferent medicines. In some§$"Ω cases, more than one drug will ☆↓©®be required for effectiv® e treatment. TNX-1600 is our third drug canβ÷≈didate in development for PTSD. Ou→§αr most advanced candidate is §ε×₩TNX-102 SL, which is in Phase 3 development. ©σWe are also developing TNX-601 which is ent★☆ering a Phase 1 trial imm< ↔inently. TNX-1600 is in the pre-IND ph₹₩↑ase of development with encouraging data from aniελmal models of PTSD.”Frank Bymaster, Chief S•≥•£cientific Officer and co-founder of ↕¶ TRImaran Pharma Inc. said, “TNX-1600 is a<& novel TRI that inhibits sim↔≠πultaneously the reuptake of÷± three key neurotransmitters: serotonin, norepin♠≈ephrine and dopamine. Each of these¥→'¥ three neurotransmitters plays ♣≥ a key modulatory role in many αΩ<CNS processes. Inhibiting reuptake of all three ₹₹®may provide an effective →♥treatment for PTSD.”According to Drδ∏↔. Aloke Dutta, “We hav>•₹e developed an innovative triple reuptake inh•↕ibitor, D-578, based on a unique pyran α♠molecular scaffold to address th₽←₩e current therapeutic needs for PTSD and other ne★∑urological disorders. Based on ÷βour preliminary data, we expect a pharm↔'★acological synergy from their potent mo÷λdulatory effect on the level of monoam≠•✔ine neurotransmitters in tβ≠♦→he brain which should facilitate effecti☆↔ve treatment of these disorder∞¶<s.”Under the terms of the agreement, To☆§×→nix has been grantedγ∞₽ an exclusive license from Wayne S♥✔™tate University for techno★ logy and patents related to TNX-1600 and othe$Ω<"r pyran-based compounds. Another member₽∞> of the class, D-473, has also shown effecε♥ts in a rodent model of depression.the 2>₽←019 Asia-pacific Pharmaceutical IP Leadeδ×r Summit will be held in ♣♠Beijing on November 14-15, and ™≤↑will attract more than 500 industry experts fromδ≥ domestic and foreign ₹♥pharmaceutical companies, biotechnolog•≤y companies, governments, associations, Ω♦law firms, intellectual pr ↕$operty agents and other companies to¶✔↔σ attend. 2019 Asia<✔±≤-pacific Pharmaceutical∏ ™ IP Leader Summit Official re<→'♥gistration and consultation channels≤<©♣:Contact:AnnPhone: 021-65☆σ$₽650305Email:Marketing@zenseegroup.↔₩comhttp://en.zenseegroup.com∏/p/510934/