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- Tonix Pharmaceuticals Expands Precli÷≤nical Pipeline with Triple Reuptake±÷' Inhibitor, TNX-1600, for the Trea←∑Ω₹tment of PTSD
Tonix Pharmaceuticals Holdin®•∞€g Corp., a clinical-stage£ € biopharmaceutical com★pany, announced today a> ♣n exclusive agreement to ★♣in-license a triple reuγγptake inhibitor (TRI), TN™♣£X-1600 (formerly D-578), to treat posttraumat♠ic stress disorder (PTSD) and potential• εly other central nervous system&₹ (CNS) disorders. The compound was¶÷✘$ developed and pharmacologically cha¶&¶racterized by Aloke Du∏×€tta, Ph.D., professor of Pharmaceutical Science£βs at Wayne State Universi♣φ★≥ty, with funding from₩δ≠♣ a National Institutes of Health grant (grant π<♣ number MH084888), and the π$§patents covering the compounds were licensed to ∑"TRImaran Pharma, Inc. (TRImaran). The××¥↑ transaction announced today is a li≈♥cense agreement with Wayne St¥ πate and an asset acquisi≤ tion with TRImaran.
“We are excited to expand our $♣φpipeline and are looking forward to devel✔φ<γoping TNX-1600 as a potential ÷&♣treatment for PTSD,” said Se€th Lederman, M.D., Tonix's Presidenφα₩✘t and Chief Executive Officer. “¶γWe plan to utilize our clinical ¥$ ®experience in PTSD to e≈★↑valuate the therapeutic benef♠∏ it of TNX-1600. PTSD is a heterogeneous conditλ•®£ion, so we believe different PTSD patients may ←σ← respond to different medicines. In $✘β®some cases, more than one drug will be♦• ★ required for effective treatment. TNX-1600 ↑₽↔ is our third drug cand® &→idate in development for P→>>±TSD. Our most advanced≤♠ candidate is TNX-102 SL, which is iγ←∞n Phase 3 development. We are α≥✔also developing TNX-601 which γ÷is entering a Phase 1 trial≥☆ imminently. TNX-1600 is in the pr♠α↔e-IND phase of development with encouragin∞ε∑g data from animal mode→Ωls of PTSD.”
Frank Bymaster, Chief Scientific Officer and∏≥∞¥ co-founder of TRImaran Pharma Inc. said, “TNX-16'¥00 is a novel TRI that inhibits simult$∏aneously the reuptake of ®£three key neurotrans→★'mitters: serotonin, norepinephrine and dopaminλ♦e. Each of these three neurotransmitter☆>s plays a key modulatory role in ↓€÷many CNS processes. Inhibiting reuptake of all th§₹↑ree may provide an effective treatment®• for PTSD.”
According to Dr. Aloke Du©≈tta, “We have developed an i×☆nnovative triple reuptake inhibitor, D-578, b≠δ¥€ased on a unique pyran molecular scaffold©∑ to address the current therapeutic needs for ♠φ∞PTSD and other neurolog✔ ♦ical disorders. Based on our preliminary da✔∞π ta, we expect a pharmacological syn&ε¶ergy from their potent mod≈δ≤→ulatory effect on the level of monoamine neu☆÷rotransmitters in the brai∏n which should facilitate effective ₩₩treatment of these dis↑"♠orders.”
Under the terms of the agr' γeement, Tonix has beenβ× ¥ granted an exclusive license from Wayne St£'™ate University for te∞ ∑♣chnology and patents related to TNX-♥<γ₹1600 and other pyran-b®±σ★ased compounds. Another member o♦γf the class, D-473, has also shown effectγ∏s in a rodent model of d γepression.
the 2019 Asia-pacific Pharmaceutical IP Leader ♣₽Summit will be held in Beijing on November α< 14-15, and will attr α¥act more than 500 industry experβ©★ts from domestic and foreign pharmaceutical compa♠π§€nies, biotechnology co≈♦σmpanies, governments, associations π, law firms, intellect$ual property agents and other companies to atte✔¶nd.
2019 Asia-pacific Pharmaceutical IP L<π€eader Summit
Official registration and consul$δ®♥tation channels:
Contact：Ann
Phone: 021-65650305
Email：Marketing@zenseegroup.com
http://en.zenseegroup.com/p/510934/
From :businessinsura$✔nceU.S. commercial property/c♣asualty rates rose 5% on ave≤"&rage in the fourth qβ÷uarter of 2019, up from 4% in tε• he third quarter, reflect♥"σπing insurers’ intent to con¥•↓tinue to increase prices acrossΩ↑λ most lines, online insurance exchange ♦☆♥MarketScout Corp. said Mondaφαγ♦y.“Auto rate increases∑ have been up all year l♥§✔¥ong; however D&O (di≠"rectors & officers)✘¥ and professional rate increases have s✔σ∏piked significantly i n the fourth quarter,” Ric¶™¥'hard Kerr, CEO of MarketScout Corp. said in ¥λa statement.Insurers are carefully analyzing the∞₹βir property exposures using catastrophe mo≈≠≤deling tools, he said. “We expect many of the ™♠≠"major property catastr∏ophe insurers to curtail their 2020✔← writings in California brush and East andα Gulf Coast wind areas. Naturally, this wil↔★l result in higher rates to insureds,” Mr.☆φ© Kerr said.D&O liabilit'™y rates increased by 8.25%, while coδ££δmmercial auto increased 8%♦↕ in the quarter, and professional liability ra✘↑♠tes were up 6%, and umbrella/excess rat" βes were up 5.5%, according to Ma♥®δ<rketScout.Commercial property rates incσ♥ ÷reased 5.25% in the quarter, and business interr® ₹uption rates were up 5%, while all∞≈" other lines showed smaller increases, except for♦© workers compensatio¶→n, where rates fell 1%, MarketScout said✘σ.By industry class, transpo₩ & rtation and habitati•αonal saw the highest average rate increa€≤ses at 9% and 8.25% respectively, M♥∑↕arketScout said.Large accoΩ♠™unts – those with $250,001 to $1 millio±π n in premium – saw a rate™™ hike of 5.5% in the fourth quarter, as did j≠umbo accounts, which have more than ✔$1 million in premium. Small aε≤↕×ccounts – those with up to $25× ←✘,000 in premium – wer™¥ e up 5%, while medium accounts – thos♥₽≈e with $25,001 to $250,000 in premium – w₩$ere up 4.5%.The “steady trend” of upward rates≠ reflects insurers’ plan≠∑s to continue increasing prices acros✔≠γs all lines except for workers∑γ₹≤ compensation, MarketScout₹& said.Organizer：China I♠↑nsurance Digital & AI Development 2020Web:hΩ♣∑®ttp://en.zenseegroup.com/p/5605 •73/Contact:Ann 021-65₽≈✔650305
From :insurancejournalIt was a••≠™ relatively quiet year for the ₽ Southeast in terms of major catastroγ≠$£phes compared with 2018 when H↑€∑€urricane’s Michael and Florence caused major dama↑≤€↓ge in the region. This year,&n≠λbsp;Hurricane Dorian→✘ sideswiped the Southeast coast and made la©©ndfall on the Outer Banks of North Carolina buφ®σσt most of the area was ¶£spared. Still, Aon said econo≠≤ mic damage in the U.¥∞♣λS. and Canada was poised to approac®♠λ↓h a combined $1.5 billion.Florida spent±±•α the year recovering from Hurricane∏≠✔ Michael, which was upgraded to a Category 5₩¶≈& storm by NOAA in April. Florida offi≈cials have repeatedly called on the insur ∏↑ance industry to speed §up the recovery process, with nearly 12% >¶of claims still open a year after γ☆the storm hit.Organizer：China♣©→≤ Insurance Digital & AI Development 2020γ∑↑Web:http://en.zenseegroup≤φ≈¶.com/p/560573/Contact:Ann 021-65650305
From:businessinsuranceeins×δurance renewals at Jan. 1, 2020, mainly ↓★φδsaw single-digit incre×€ases, with some exceptions, acco'£rding to reports by reinsu∞↕&rance brokers released Thu≥&αrsday.Willis Re, the ©λ©reinsurance brokerage of Willis Towers Wat¶ε™₩son PLC, and Guy Carpeλ±εnter & Co. LLC, a unit ¶δ≈of Marsh & McLennan C←↑<≥os. Inc. both reported tha∞£t year-end reinsurance renewals πvaried by account and region, but the retrocessio¥←≥nal reinsurance was und σer pressure.Rates on line for property catas✘∑≥♣trophe reinsurance programs remained stable and φproperty per risk pricing was driven b§" y individual program performance, the W εillis report said.Although some Lloyd’s of London×♥• syndicates took firm positions on rate inc>∑ ₩reases and the London market authorized capaciεφ§ty decreased, that capactiy was replace→∏₽d by new capital and♦♣↑ a strong supply from other market₩✘s, Willis Re said.U.S.×φ loss-free accounts renewed at ★₩δflat to up 10% while thosσ"π♥e with losses saw increases of 10% to 50%, the Wi$★∞♦llis Re report said, which was £♣>among the largest increases. Prop≥erty catastrophe accounts withou¶$λt losses renewed at flat ÷βγ to up 5%, while loss hit accounts were up 10%≈ € to 20%, Willis Re said.A↑λ<₩ccording to the Guy Carpenter report, the broαש✔kerage’s global property cata✘✔÷εstrophe rate on line indeγ≈ x rose 5% in 2019.According to the Willis Reφ σδ report, other large increases were Ωδseen in Central and Eastern Europe, where<★ property programs with losses saw ¥€₽increases of 5% to 20%, and Canada, wh©'ere such accounts reneweφ₹₩↑d up 10% to 40%.Most other reg←↕πions and countries saw property increases in the single or low d¶ ouble digits, the report s←αaid.The Jan. 1 renewals saw some “difficult” ♣₹σ$negotiations, according to a l✔αααetter in the report from James Ke₹§→≤nt, global CEO, Willis Re∏ .The Guy Carpenter rep §€ort said the reinsurance mar®✔♠ket was “asymmetrical,” adding “this♥₽ is certainly not a one-size-fits≤ -all market” and while over♠™$≠all capacity remained adequate, “allocatedδ< capacity tightened notably in stresse♠≈™→d classes.”Dedicated reinsurance capital rose •↕♦2% in 2019 and the yeδφδar saw approximately $60 &♥αbillion in global insured cata☆Ωstrophe losses, according to Guy Carpenter,♣¶ which was significantly lower than 2017 ≤₽and 2018.Alternative capital, howev♦>er, contracted by approximately 7% percent “as ≤♣'investors were more cautious with new investm €ents after assessing mark∑$et dynamics and pricing adequacλ$y,” Guy Carpenter said.The <↑€$retrocession market “was challenged … by trapped× capital, a lack of new capital and cont> ↕inued redemptions from third-party capital≠↓ providers,” a statement issued w•↔↓ith the Guy Carpenter report said↔←.However, significant retrocessiβon providers returned ÷♥to the market in the past two we>∑↓eks, Willis Re said.Organizer：China Ins∑↑urance Digital & AI Development 2020Web:httπ ✘p://en.zenseegroup.com/p/56057∏♣3/Contact:Ann 021-65650305
Major information technology companies in India aλβre running the risk of termination of their $1✘©↑ billion contracts following Boeing Co.< ’s decision to halt the prλ oduction of its 737 Max₩≤♠ jets, MoneyControl reported citing thαφe Business Standard. Companies like Tata Consult •πancy Services Ltd., Infosys L£<÷♦td., HCL Technologies Ltd., Cyient Ltd. an≈$✘d L&T Technology Servic↕♦ ☆es Ltd. have outsourcing contracts with Boei≠×ng or its suppliers and Boeing’s ¶$ jet crisis is expected to affect these IT §"₩companies in the short run.From:businessinsuran✔ceOrganizer：China Insurance Digital &䙶♠ AI Development 2020>£÷<Web:http://en.zenseegroup.com/p/560573/Contac<δt:Ann 021-65650305
France-based eyewear mak♦Ω¥er Essilor International S.A. has γπβdiscovered fraudulent activities a'"t one of its factories in Tha₽α iland that could cause €190 million ($213 mi¶★÷™llion) in financial losses t ✔♦o the company, The I✘←$rish Times reported citin↔βg Reuters. The company has filed comβ plaints in Thailand andφ↕♥ has fired all the involved emp×∞φ"loyees. It hopes to recover t©₩ he losses from frozen bank accounts, insurance an®✔d lawsuits.Organizer：China Insurance DigitalΩ÷δ & AI Development 20δ♦↕20Web:http://en.zenseegroup.com/p/560573/Co♣εntact:Ann 021-65650305
