Catabasis Pharmaceuticals and the JainΩλ Foundation Announce a Pre∏↕→clinical Research Collaboration to Stσφεudy Edasalonexent in Dysferlinopathy
Catabasis Pharmaceuticals, Inc., a c↔£linical-stage biopharmaceuti"&cal company, and the Jain Foundation, a non-profi↑♣∏£t foundation whose mission is tλ o cure muscular dystroph®≥→ies caused by dysferlin protein deficiency§βα, announced a precli±™nical research collaboration to s¶ ₩tudy edasalonexent (CAT-1004) in Dy$£Ωsferlinopathy. Dysferlinopath∏∞♦$y (Limb-girdle muscular dyσ→αstrophy type 2B / Miyoshi myop♦≤★φathy) is a serious rare¥♦σ disease that causes progressive mus≈♦ cle weakness for which t∞σ"here are currently no approσ•ved treatment options. Edasalonexent is in Phase ₽÷3 development for the treatment of Duchσ₽®enne muscular dystrophy (DMD) and has the poteγ≠ntial to benefit patients with other disα&Ωeases, such as Dysferlinopathy.In ">Dysferlinopathy, mus'≤cles lack dysferlin and as a result ✔NF-kB is chronically activated. Ed↕γΩ♥asalonexent, an oral smal€÷β®l molecule designed to inhibit >₽NF-kB, has the potential to sl&™>ow disease progression in dysfe∑™☆§rlin-deficient populations. §πεUnder this collaboration, Catabasis ₩₩>δand the Jain Foundation are conducting a pre≤™≤clinical study to ev♠↔✘aluate the potential •♣>of edasalonexent as a therapeutic interven'<tion for Dysferlinopath☆σ✘y by measuring disease progression↔♣ in dysferlin-deficient mice treated α↑₹with edasalonexent. The study will ut×←☆✔ilize magnetic resonance imaging (MRI) an•d magnetic resonance spectrδ♣oscopy (MRS) to measure muscle volume, fat acε↑€₹cumulation, and other changes in the dysferlin-★γdeficient mice. Initial results are ex€£∏pected in the first half of 202 ₽0.“We look forward to workin ∏§g with Catabasis to advance r$®esearch for Dysferlinopathy,” sa∑↓βid Laura Rufibach, Ph.D., λ★₹and Doug Albrecht, Ph.D., Co₽Ωβ-Presidents of the Jain Foundation. “Patients wit∞¥h Dysferlinopathy (LGMD2B / Miyo™"σ≠shi myopathy) experience a pro™↑€gressive and debilitatiπγng decline in muscle functi♣☆on which significantly £∑ impacts their lives. As there are currently π•no treatment options, we are e¶>↓♥xcited to explore the potential of edasa≥≤φlonexent to benefit those l ®¶∑iving with this disease.”“T↔↕he chronic activation of NF-kB is a ke<€×y driver in many neuromuscular disorders, in ✘cluding Duchenne muscular d↕•ystrophy. Evidence of NF-kB≠' activation in Dysferliα↓nopathy suggests a simi € ₩lar disease mechanism and opportunity fo♠™≈r intervention. In the MoveDMD trial and §αopen-label extension, trea←£tment with edasalonexent slowed disease•∞ progression compared to the off-treatmeφαεnt control period. Throu∞☆★gh this collaboration, we look forward to learn ÷σing more about the potential of edasalonexent↕β in Dysferlinopathy, where, similar ∑♣$∏to Duchenne, there is also a≤δ"₩ significant unmet need,” said Andrew Nichols, P∞₽h.D., Chief Scientific Officer a₩ππ∏t Catabasis Pharmaceuticals.information sou₩ "&rce:pharma focus AsiaThe original link:ht≥₽∑÷tps:https://www.phar£✘mafocusasia.com/news/catabasis-≈ <λpharmaceuticals-and-the-jain-foundation-announ♥≥↔ce-a-preclinical-rese§φ✘arch-collaboration-to-study-edasalonexent-in-dyγδ∑'sferlinopathy2019 Asia-pacific phar γma IP Leader Summit: http:σ÷™//en.zenseegroup.com/p/404716/ ≤will be held in Beijing ∑∞on November 14-15, ✘≥€and will attract more than 500 industry₩∏↕ experts from domestic and foreign p←harmaceutical companies, biot• echnology companies, ∑ governments, associations, law firms, in₩™&tellectual property agents and other companies§∏£± to attend.Official registration and ↕λ♦☆consultation channels:Contact:AnnPhoσ"™ne: 021-65650305Email:Marketing@zenseegroup.com×http://en.zenseegroup.com≤"≤ /p/510934/