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- NeuCyte Licenses Promisin>∑₽g Novel Compound for Trea€<•tment of Refractory Epilepsy and Related Neuβ≈☆rological Disorders
NeuCyte, Inc., an innova€ ¥©tive biotech company focused on develo₩'δ♥ping novel treatments for n✔♥♣eurological disorders, today announced σ'÷that it has entered into an exclusive license aπ™±greement with Trillium Therapeutics to advance a≥φ>©n undisclosed preclinical com""pound with potentialγ☆♦α utility in treating refractory ®★÷ epilepsy in the form of Dravet sy™$ndrome and related disorders.
The compound covered by this agreemπ✘₽ ent has demonstrated highly encouraging Ω activity during studies conducted by the☆σ☆ National Institute of Neurological Disorders an→✘©εd Stroke (NINDS) Epilepsy Therapy Sα ♥creening Program (ETSP). It demonstrates a αsuperior safety and anti-seizure efficacyλ÷ profile over NINDS benc↓©hmark anti-epileptic drugs (AEDs) in eleven• ♥ animal models. It has al≤₹¥so demonstrated broad efficacy in NIH an×★±imal studies for pharmaco-resistant epile↕✔✔↑psy. As a result, this novel agent₹§π∑ has gained the prestigious NINDS Red Book™≥ status and been selected as a promisi☆€ng lead drug candidate.
"This compound is an exceedingly pλ₹romising antiseizure drug which, although in£>π¥ preclinical development, is quite efγ✘↔₽ficacious in a wide variety of h ↓σighly predictive seizure models," said Rogerσε" J. Porter, MD, Adjunct Pr©§ofessor of Neurology at the University of Pennsyl γ★vania, former Deputy Director of Nλ•INDS, former Chairman of the White House Committπ ↑ee on Brain and Beha×™ vioral Sciences, and former Pre↕✘↓₽sident of American Epilepsy Soc<π§iety. "It may prove very effective for patient ∏♣÷s with epilepsy." As a first-in-class c≤♠Ω±ompound with unique mechanism of a <¶ction profiles, this drug→ε<✘ candidate is likely to have activity acro£ss a variety of indications. The favo≤★rable efficacy and s>>✔←afety profile has also been validated b∞ε≤→y NeuCyte's proprietary in ∞vitro human iPSC-derived models. ₹
"Epilepsy is the fourth m✔σ×ost common neurological disea®'→se affecting more thσ×an 65 million people of all ages £±worldwide. The complex and multifac Ω torial nature of the disorders m ♦©akes treatment complicated and challenging. ☆Up to 40% of newly diagnosed epilepπ↔¶"sy patients are resistan&±↕t to current therapies which highlights the urg βφent need to develop first-in-class treatmen>♥ts," said Jacqueline A. French, MD, Chief'$™÷ Medical and Innovation O$∑fficer of the Epilepsy Foundaαβ≈"tion and epileptologist in New York Cit™$•y. "It is very encouraging to see n•¥λ₩ew developments and therapeutic can$≥didates in this disease∞↔↕≈ area."
Under the terms of the agreement, Trilli♠<±®um has granted NeuCyte exclusive, worldwid✘δe rights to develop and commercialize t&™he compound. "NeuCyte is committed to br∞¥™inging breakthrough therapies to epilepsy pλβ§atients and believe that our advantageous tδ•σ₹ranslational technology×× platform and CNS expertise en©↔able us to optimally advance suc✘↓h therapeutic candidates," said Tao Huang, Ph₽₩ D, JD, President and Chief Executive Officer of N₩₹euCyte. "This licensing agreement allows u' s to expand our pipeline and advance our goal €♣of meeting unmet clinical needs a☆'εnd truly improving patient care and qual¥₩ity of life."
information source:pharma focus Asia
The original link:https:https:https://www.pharmafocusasia.comΩ•/news/neucyte-licenses-promising-novel-compound-₩≈•for-treatment-of-refractory-epilepsδ≈±₹y-and-related-neurologi☆€cal-disorders
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From :businessinsuranceU.S. com£₹mercial property/casualty rates ro ★©≥se 5% on average in t←±he fourth quarter of 2← ₹019, up from 4% in the third quarter, reflect¥∞ing insurers’ intent to continue to in≥λ£crease prices across most lines, online γα€αinsurance exchange MarketScout Corp. said Mλ↔€onday.“Auto rate increases have been up al↓ l year long; however D&O (director>≈s & officers) and professional rat¥λ±e increases have spik Ωσδed significantly in th₽≥e fourth quarter,” Richard Kerr,$ CEO of MarketScout Corp. said in a state£σment.Insurers are carefully analyzin↓↓≥§g their property exposures using catastrophe mo€>•deling tools, he said. “We expect many of the §$major property catastrophe insurers to ≤☆≤curtail their 2020 w®€↔ritings in California brus$♠εh and East and Gulf Coast wind areas. Natur™≥ally, this will result in h₽¶↓igher rates to insureds,” Mr. Kerr said.D£ε• &O liability rates increased by 8.2×♦5%, while commercial auto increased 8% £φλin the quarter, and professional liability rates€♥∞ were up 6%, and umbrella/excess rate∞✔s were up 5.5%, according to MarketScout.Co✘δ ¥mmercial property rates increased 5.25% in the→↓ quarter, and business interruption rates we©<™¶re up 5%, while all other lin<∑es showed smaller increases, except for workers γcompensation, where rates fell 1%, MarketSco ¥ut said.By industry clas☆ s, transportation and habitational saw the high✔$∞est average rate increases ₩€¶at 9% and 8.25% respective¶πly, MarketScout said.Large •₩¶accounts – those with $250,001 to $☆≠"∏1 million in premium – saw a rate hike of 5.5% i¶≤n the fourth quarter,β∏ as did jumbo account¶σ←'s, which have more than $1 million in premium ε". Small accounts – those with up to $&Ω25,000 in premium – were upε> 5%, while medium accounts – those with $2 ±₹ 5,001 to $250,000 in premium – were up 4.5%.The “ steady trend” of upward rates reflects insur★₽ers’ plans to continue increasing pri≤π¥λces across all lines exce✔÷pt for workers compensat≠×☆ion, MarketScout said.Organi¥♣zer：China Insurance Digital & AI Developmeε∑→nt 2020Web:http://en.zenseegroup.com/p/5605₽±↔73/Contact:Ann 021-65650∑ 305
From :insurancejournalIt wasε≥₹< a relatively quiet year forφ↓× the Southeast in terms of major catastro <ε¶phes compared with 2018 when Hur÷<≈ricane’s Michael and Florence↕♠≈≥ caused major damage in the ≤"©region. This year, Hurricane Dorian sideswipπ©₹≤ed the Southeast coast&σ≈β✔nbsp;and made landfall on th₽>e Outer Banks of North Carolina but most of ↕¥βthe area was spared. Still, Aon said e÷↓↕'conomic damage in the U.S. and Canada w∞ ♠↓as poised to approach a combined $1.5 billion ♥.Florida spent the yea ¥r recovering from Hurε∏&₩ricane Michael, which was upgraded to a ≈≠Category 5 storm by NOAA in April. Florida officiα£ §als have repeatedly calle↕±$d on the insurance inλdustry to speed up the recσ 'overy process, with nearly 12% of claims s±&↔till open a year after ✔↓ the storm hit.Organizer：China Insurance D'©igital & AI Development 2020Web:http://en.ze""↑nseegroup.com/p/560573/Contact:Ann 021-π<♦65650305
From:businessinsuranceeinsurance renewals ₩↕αat Jan. 1, 2020, mainl÷λy saw single-digit increases, w←↑ith some exceptions, accor↕ding to reports by reinsurance brokers released ¶×©>Thursday.Willis Re, the reinsurance br↔β₽'okerage of Willis Towers Watson PLC, and Guy •ΩCarpenter & Co. ↕↕LLC, a unit of Marsh & ♥σ¶ΩMcLennan Cos. Inc. both reported that year-end r±¥ einsurance renewals varied by acco≤<unt and region, but the retr♥↓≥λocessional reinsurance was under pressure₹σ.Rates on line for property cat'"γ↑astrophe reinsurance programs remained stable ♦&and property per risk pr€ ©icing was driven by i$≤☆ndividual program performance, the Willis report✘§ said.Although some L§★≥δloyd’s of London syndicates took firmε☆ positions on rate increases and the London ma↕β$rket authorized capacity≤Ω decreased, that capactiy was repl↕₽×aced by new capital and a strong supply frαΩom other markets, Willis Re said.U.S. loss-fre∏ε¶e accounts renewed at flat to up 10% •©while those with losses saw increa $≤ses of 10% to 50%, the Willis≈Ω Re report said, which was among the εσlargest increases. Property catastrophe acco₽ε¥unts without losses renewed¶£>γ at flat to up 5%, whil¥™e loss hit accounts were up 10%™® to 20%, Willis Re said.According to the Guy Carp>×enter report, the brokerage’•©s global property catastrop€®he rate on line index rose 5% in 2019.Ac→δcording to the Willis Re repoσ ♠≈rt, other large increases were seen in Central £÷and Eastern Europe, where♣' property programs with÷'λε losses saw increases of 5% to 20%, and Can§α•¶ada, where such accounts renewed >☆'&up 10% to 40%.Most other regions and couπ↑ntries saw property increases in the single or≠® low double digits, the report said.The Jan. 1 rπ✔enewals saw some “difficult” negotiations, accord•™ing to a letter in the report from Ja∏€φmes Kent, global CEO, Willis Re.The Guy Carpente∏®r report said the rein"<"×surance market was “asymmetrica≈₹l,” adding “this is certainl×∏★y not a one-size-fits-all marΩ☆¥σket” and while overall ca εpacity remained adequate, “alloca≠↔ted capacity tightened notably in stressed cl÷"•asses.”Dedicated reinsurance capital rose 2%±'✔ in 2019 and the year saw approximatel↕≠δy $60 billion in global insured catastrophe los™"↕ses, according to Gu®₽y Carpenter, which was sign✘δificantly lower than 2017 and 2018.Alternati←¶ve capital, however, contracted by approximatel↓δπy 7% percent “as investors were λ≈more cautious with new investments after asses♦♠sing market dynamics and¥™€ pricing adequacy,” Guy Ca↑↔≤"rpenter said.The retrocession market “was ch☆↓→σallenged … by trapped capit≠•φal, a lack of new ca Ωpital and continued redempti¶∏ons from third-party ca$§pital providers,” a stat÷™ement issued with the Guy Carpenter report said.✔♥However, significant retroc→₹Ωφession providers returned tβσ×♣o the market in the past two weeks, Willis Re ✘said.Organizer：China Insurance Dig←≠'₩ital & AI Development 2020Web:http://en.zensδδ•eegroup.com/p/560573/Con♦≤¥tact:Ann 021-65650305
Major information technology companies in India₩✔• are running the risk of ter mination of their $1 billion contracts foll≥₩owing Boeing Co.’s decision to halt the producπ™→®tion of its 737 Max jets, MoneyControl r'βeported citing the Business S↔<tandard. Companies like Tata Consu&≤ ltancy Services Ltd., Infosys Ltd., H♦↑CL Technologies Ltd., Cyient Ltd. and ÷♣☆L&T Technology Services Ltd. ≈πhave outsourcing contracts with Boeing or its ☆∑≠Ωsuppliers and Boeing’s jet crπδ↕&isis is expected to affect these IT companiβ£es in the short run.From:businessinsuranceOrgani≈σ↓zer：China Insurance Digital & AI Developm≈>ent 2020Web:http://en.zenseegroup.com/¶→≈λp/560573/Contact:Ann 021-656"∑π50305
France-based eyewear maker Essilor &≤'International S.A. has discov₩♦ered fraudulent activities at one of its fac♥↑§•tories in Thailand that coδ §uld cause €190 million→$ ($213 million) in financial losses to th¶∞e company, The Irish Times reported &₽÷citing Reuters. The company has filed 'λcomplaints in Thailand and has fired all tδ≈★πhe involved employees. It hope←™¥s to recover the losses₹< from frozen bank acco¥σαunts, insurance and lawsuits.Organizer：China¶≤ Insurance Digital & AI Development 2020Wπ≤eb:http://en.zenseeg®±roup.com/p/560573/Contact:Ann 021-6565030×↑5
