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I-Mab Biopharma Announces Clinical Col↓>laboration to Evaluate TJC4 in Combination wi→εth KEYTRUDA® (pembrol÷∏£izumab)
2019-09-25

I-Mab Biopharma ("I-Mab"), a↔Ωφ China and U.S.-based clinic↓₽α≥al stage biopharmace♠☆∑​utical company exclus±πively focusing on the discovery and develo•×pment of potential first-in-↓₩class and best-in-class biologics Ω₽♦in immuno-oncology and aut§←oimmune diseases, today ann &↑ounced that it has enter←λ®ed into a clinical research collabor$‌ ÷ation agreement with MSD, a tradena±≈₩me of Merck & Co., Inc., Kenilwo  rth, NJ., USA, to evaluate the combination of I↔→-Mab's TJC4 and MSD's anti-PD-1 therapy, KEYTRUDA↑₽↓σ® (pembrolizumab) in patients with multiple caπ®ncer types.

Under this collaboration agreement, M≠★©≈SD will supply KEYTRUDA® ↓♠(pembrolizumab) to I-Mab for use iΩ↓ ↔n clinical studies in δα♥☆combination with TJC4, a fully human anti-CD47 mo₩☆≠↔noclonal antibody. Both parties wi​αll collaborate on a Phase 1 clin☆∞'ical trial, based on an agreed γδand finalized protocol, to evaluate the safety, ↔≈pharmacokinetics, phaε×¶λrmacodynamics and prelimin₩>ary efficacy of TJC4 and KEYTRUDA® in p↕≈¶<atients with multiple cancer types.€↕λ 

"TJC4 is a highly differentiated↓∏αΩ anti-CD47 antibody <★$$currently under clinical develoβ pment. This collaboration wil"↔<l provide an excellent opportun↕₩ity to further explore therapeutic potential oβ •↕f combining TJC4 with KEYTRUDA® across different λ¥>λtumor types." said Dr. Jingwu Zang, F¥<ounder and Chairman of I-Mab.

KEYTRUDA® is a regis∞£™<tered trademark of Merck Shar×πp & Dohme Corp., a subsidiary of M >erck & Co., Inc., Kenilworth, φ✔‌ NJ, USA.

information source:pharma focus Asia

The original link:https://www.pharmafocusasia.com/news/iλ↔±-mab-biopharma-announces-clinical-collaborα↑∏ation-to-evaluate-tjc4-in-combi§<γnation-with-keytruda

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From :businessinsuranceU.S. co‌δλ±mmercial property/casualty rates rose 5% on ave↕ rage in the fourth quar←✔​♥ter of 2019, up from 4% in  ✔ the third quarter, reflecting insurers’ i≈β≠ntent to continue to increase prices across mos∏₽πt lines, online insurance exchange MarketSco ≥ ut Corp. said Monday.“Auto rate increδ "©ases have been up all yea λ✔r long; however D&O (direφ♠♦&ctors & officers) ∏∞π>and professional rate increa​∞​ses have spiked significantly i→¥n the fourth quarter,” Richard₹‌ Kerr, CEO of MarketScout Corp. said •λ∏☆in a statement.Insurers are →←αγcarefully analyzing their propertyπ​£♠ exposures using catastrophe modeling to✔÷απols, he said. “We expect many of th©★¶≥e major property catastrophe insurers to curtail÷↓₽& their 2020 writings in California brush and Ea&↑st and Gulf Coast wind areas. Natura↕☆lly, this will result in higher rateπ∏≤£s to insureds,” Mr. Kerr said.D&O liability r¥←₽ates increased by 8.25%₹ , while commercial auto increased 8% in £ε'↓the quarter, and professional liability ratσ₹es were up 6%, and umbrella/excess rates we ☆"re up 5.5%, according to Maεε βrketScout.Commercial pr₩π∞operty rates increased 5.25% in the ✔ ‌quarter, and business interruption rates Ω€πwere up 5%, while all oth←‍εer lines showed smaller increases, e γ&γxcept for workers compensation, wh¥↔ere rates fell 1%, MarketScout§≥∑ said.By industry class, tran♣≥® sportation and habitational saw''σ the highest average rate incre "₽ases at 9% and 8.25% resp÷•™ectively, MarketScout said.Laππ"rge accounts – those with $2∑♣ 50,001 to $1 million in premiumε≈ – saw a rate hike of 5.5%"¶≥ in the fourth quarter, ®↓ as did jumbo accounts, which h<‍ •ave more than $1 mil£±♦$lion in premium. Small a"♠✔<ccounts – those with up₽"φδ to $25,000 in premium – were up 5%, while me©€dium accounts – those with $25,001 to $250,000 γ in premium – were upו​ 4.5%.The “steady trend” ofε¶ upward rates reflects insurers’ plans to¥≈★  continue increasing prices a←‍cross all lines except for workεε‌>ers compensation, MarketScou 'αt said.Organizer:China Insurance Digital &↕π‌amp; AI Development 2020Web:http://e✔↔n.zenseegroup.com/p/560573/Contact:Ann ¥βα®021-65650305

From :insurancejournalIt was a  φrelatively quiet year fo♦πr the Southeast in ter×♥→↓ms of major catastrophes compared with 2↕> 018 when Hurricane’s Michael and Florence cause↔↑"d major damage in the ∑&region. This year, Hurricane $≈₽Dorian sideswiped the Southeast coast∏' and made landfall on the Outer Bankγ↕s of North Carolina but most of the area was ↓​βspared. Still, Aon said econo∞¥®γmic damage in the U.S. and Canada was poise™↕∑d to approach a combined ♣∑♥$$1.5 billion.Florida spent the year reco♣∑<vering from Hurricane Michael,≤♦ which was upgraded to a Category 5 storm λ' by NOAA in April. Florida officials have repeate¥↕β÷dly called on the i∏≥nsurance industry to→<★ speed up the recovery process, with nearly 12%¶α of claims still open a year after ​$¶≠the storm hit.Organizer:China Insuφ™φrance Digital & AI Developmen€→t 2020Web:http://en.zenseegroup.com/p±​φ/560573/Contact:Ann 021-65650305

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France-based eyewear maker Essilor Internationa→₽l S.A. has discovered frau≥®♠dulent activities at one of its factories'♠↔ in Thailand that couldλ•← cause €190 million ($213 million) in fin₩∑ancial losses to the company, The™₹↔  Irish Times reported citing∏γ≈₹ Reuters. The company has λ↔₩filed complaints in Tλ©hailand and has fired   all the involved employees. Iα¥≠t hopes to recover the losses from frozen bank a≈÷¶≈ccounts, insurance andΩ✔ lawsuits.Organizer:China Insurance DigΩ¥±‌ital & AI Development 2020Web:http://en.ze&≈nseegroup.com/p/560573/Co'→÷£ntact:Ann 021-65650305

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