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- Catabasis Pharmaceuticals and the Jain Foundatio®♣&n Announce a Preclinical Resear•δ→✔ch Collaboration to Study Edasal₹∞onexent in Dysferlinopathy
Catabasis Pharmaceuticals, In'÷∞c., a clinical-stage biopharmaceutical<'• company, and the Jain Foundation, a non-φ≥ profit foundation whose misλ≥sion is to cure muscular dystrophies cau→$→sed by dysferlin pro™× &tein deficiency, announced a preclinical resear★↑ch collaboration to study edasalo∏∏±nexent (CAT-1004) in Dysferlinopathy. Dysfer$✔₹linopathy (Limb-girdle muscular dys♣ trophy type 2B / Miyoshi myopathy) is a serious ↔♦rare disease that cau↕™××ses progressive muscle weakness for whi¶σ"ch there are currently no aγ ©≤pproved treatment options. Edasalonexen ©Ω♣t is in Phase 3 development f ≠✘or the treatment of Duch Ωenne muscular dystrophy (DMφ♠D) and has the potential to benefit patien™σ♠ts with other diseases, such as Dysferlinopathy.↔→
In Dysferlinopathy, muscles lack dysferlσΩ↕in and as a result NF-kB is ch✘ γronically activated. Edasalonex ♣γ€ent, an oral small molecule designed to inhibit <↑ NF-kB, has the potential to slow disease prog¥♣ression in dysferlin-deficient popu¶ lations. Under this c∞α'ollaboration, Catabasis and the Jain ≈ε¶↑Foundation are conducting✔★Ω a preclinical study to evγ""aluate the potential of edasalonexent★∞ as a therapeutic intervention for ε₩ βDysferlinopathy by measuring disease progression €✔↔in dysferlin-deficient mice>¥↕ treated with edasalonexent. The study wi≠ ll utilize magnetic re©→®"sonance imaging (MRI) and magnetic r ♦ esonance spectroscopy (MRS) to mea≥λφ¶sure muscle volume, fat±↑γ accumulation, and o ←∞∞ther changes in the dysferlin-d££∑eficient mice. Initial results are expe≤↑§cted in the first half of 20¶≥20.
“We look forward to working wi•÷™th Catabasis to advance res≤←↔earch for Dysferlinop¥♥©athy,” said Laura Rufibach, Ph.≤&"D., and Doug Albrecht, Ph.D., Co-Presidents o✔☆™f the Jain Foundation. & “Patients with Dysferlinopathy (LGMD2B / Mi®≤yoshi myopathy) experience a progressive"™₽ and debilitating decline inΩδ↕≥ muscle function whic∞∞h significantly impacts their lives. As th↑¶≠£ere are currently no treatment options, w €>♦e are excited to explore the λ εpotential of edasalonexent to beneγ€₩fit those living with •&✔•this disease.”
“The chronic activatioα↓ "n of NF-kB is a key driver in many neuromus→§cular disorders, including Duchenne muscular dysπλ₹trophy. Evidence of NF-kB act€♥±ivation in Dysferlinopathy suggests a simiσlar disease mechanism and opportu∞×nity for intervention. In the ∏Ω'MoveDMD trial and open-labelβ≠ extension, treatment with edasalonexenဧ≤t slowed disease progression compared ₩∏↔★to the off-treatment control period. Throu≤α×gh this collaboration, we look forward to le↕ ↓€arning more about the potential of edasalon&♣exent in Dysferlinopathy, where, si&☆milar to Duchenne, th♣©ere is also a significant unmet need,” s☆↔☆aid Andrew Nichols, Ph.D., Chief Scientifi"α↕☆c Officer at Catabasis Pharmaceuticals.
information source:pharma focus Asia
The original link:https:https://www.pharmafocusasia.com/news/ca÷<&tabasis-pharmaceuticals-and-the-jain §∞'-foundation-announce-a-preclinic↔←↓al-research-collaboration-to-study-edasalonσ™≥exent-in-dysferlinopathy☆₹←→
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From :businessinsuranceU.S. commercial pγ•$roperty/casualty rat♦☆es rose 5% on average in the fourth quarter of 20Ω"19, up from 4% in the third quarter, refleπ☆★φcting insurers’ intent₹∞ to continue to increase prices across ∏₹'most lines, online insurance exchange MarketSco£Ω✔≈ut Corp. said Monday.“Auto rate i★α®ncreases have been up all year♣ ← long; however D&O (d♠"§irectors & officers) ₽♥and professional rate increases hav✘'e spiked significantly in the fourth q→"'>uarter,” Richard Kerr, CEO of MarketSc♥∑out Corp. said in a statement. π≤$Insurers are carefully analyzing their prop>£erty exposures using c<ε↕atastrophe modeling tool★♥§s, he said. “We expect many of the ma©£ββjor property catastrophe → ♠insurers to curtail their 2020 writings ♥₽★ in California brush and East and Gulf ✔∏< Coast wind areas. Naturally, this will >$result in higher rates to insu♠'←reds,” Mr. Kerr said.D&a"™±λmp;O liability rates increased by 8.2≤↔σ5%, while commercial autπo increased 8% in the quarter, and γ≥ professional liability ratesπΩα∞ were up 6%, and umbrella/excess rates w∑¶§ere up 5.5%, according to Mark♣•ΩetScout.Commercial property rates increased 5.25%'§ in the quarter, and business ©≥£interruption rates were up 5%, while all o↓γ₽φther lines showed smaller increεγases, except for workers coβ♣≤∞mpensation, where ra€¥Ωtes fell 1%, MarketScout said.By industry c¶'★lass, transportation aδ••nd habitational saw the highest average rate inc★₽reases at 9% and 8.25% respectively, MarketSc♥↑out said.Large accounts – ∏ ✔•those with $250,001 to $1 millio₩↓'n in premium – saw a rate hike of 5.5% in₽± the fourth quarter, as did jumbo accounts,&↔♣ which have more than $1 million in prem≤∞"♣ium. Small accounts – those with up to®↔ $25,000 in premium – were up 5%, while m↔™±edium accounts – those with $25,001 ♦↑≈to $250,000 in premium – were up 4.5%.Th↔ש≥e “steady trend” of upward rates reflec×Ωts insurers’ plans to continue increas↔≤ "ing prices across all lines except for w π£orkers compensation, MarketScout said.Organizer：C★₽hina Insurance Digital & AI Development 2020W±÷↕eb:http://en.zenseegroup.com/p/560573/C♦βφontact:Ann 021-65650305±♣☆↓
From :insurancejournalIt Ωβwas a relatively quiet year for the Southea§₩♣$st in terms of major catastrophes co↔∏<mpared with 2018 when Hurricane< ≤≤’s Michael and Florence caφεφused major damage in the region. ¶δThis year, Hurricane Dorianπ€∑ sideswiped the Southeast coast and mσ$∏εade landfall on the Outer Banks of •North Carolina but most of th±§™e area was spared. Still, Aon said eco↔♥nomic damage in the U.S. and&♦↕ε Canada was poised to approach a combiεned $1.5 billion.Florida spent the ye÷↑"ar recovering from Hurrica♠δ↕♦ne Michael, which was upgraded ≥™&to a Category 5 storm by NOAA in April. F↑↓lorida officials have repeatedly ¥;called on the insurance industry to speed upσ→σ♥ the recovery process, with nearly<∑×" 12% of claims still ope'★Ω§n a year after the storm hit.Organizer：China In€surance Digital & AI Develop∑δ"ment 2020Web:http://en.zenseegroup.com/p/560573←</Contact:Ann 021-65650305
From:businessinsuranceeinsurε ance renewals at Jan. 1, <©"2020, mainly saw single-digit increases, with"βλ₽ some exceptions, accordin♥≥g to reports by reinsurance broke""★rs released Thursday.Willis Re, the r₽∞γeinsurance brokerage of &★≤∏Willis Towers Watson'® PLC, and Guy Carpenter & Co. LLC, a un£≈★it of Marsh & McLen₽π→≠nan Cos. Inc. both reported that year-end rei βnsurance renewals var"✔ied by account and region, but the ret®≠£rocessional reinsurance was under pressure.Rat♠¶ es on line for property catastr♦✔ophe reinsurance programs remained stable ♦∞and property per risk prγ →♠icing was driven by individεεual program performance, £♥the Willis report said.Although s↕★&ome Lloyd’s of London syndicates took ↕firm positions on rate inc ₽Ωreases and the London market a↑>↔uthorized capacity decreased, that capactiy wa✔$s replaced by new capital and a st™∏®rong supply from other maβΩ₽πrkets, Willis Re said.U.S. loss-fre"•e accounts renewed at flat to up 10% while those ™←"&with losses saw incrφ÷₽eases of 10% to 50%, the Willis Re rα' eport said, which was among the large•¥st increases. Property catastrophe accounts wi☆<thout losses renewed at flat to up 5%, whγσ←ile loss hit accounts were up×× 10% to 20%, Willis Rε÷σ$e said.According to the Guy Carpen™↕★ter report, the brokerage’s glob§€al property catastrophe rate on line i"✔σ®ndex rose 5% in 2019.According to the Willis Re∏€ report, other large increases were✘ seen in Central and Eaσ©₹stern Europe, where property programs with lossesγε saw increases of 5% to 20%, and Canada, where s≈∏★ uch accounts renewed up ← 10% to 40%.Most other regions and₩♣ countries saw property increases in♠λ∏ the single or low double digits, the report sπ ♣aid.The Jan. 1 renewa'€★ls saw some “difficult” n✔¶egotiations, according t$≤o a letter in the re÷>↕port from James Kent, global CEβ₽O, Willis Re.The Guy Carpen±•αter report said the reinsurance market was “a™≈symmetrical,” adding “this is certai★♠<nly not a one-size-fits-all market” and while ov±×erall capacity remainedφ₹ adequate, “allocated capacitε↑±y tightened notably in stressed c≥∞φlasses.”Dedicated reinsuranσ✔≠♥ce capital rose 2% in 2019 an✔&d the year saw approximately $60 billion♦®&± in global insured cat ♠©≠astrophe losses, according to Guy Car§&₽'penter, which was significantly →♣♦↕lower than 2017 and 2018.Alternative ca 'pital, however, contracted by approximately 7™©₹% percent “as investors were more cautious w∞±↔↑ith new investments after assessing market dynami≥→cs and pricing adequacy,” Guy Carpenter sa♣β÷id.The retrocession market “was chall→&enged … by trapped capital, a lε×♠ack of new capital and con§πtinued redemptions from third-party capital ®δproviders,” a statement i∑γ±ssued with the Guy Carpenter rep'↕₹ort said.However, significant retrocession proviλ ¥£ders returned to the market in the past two we÷£±♥eks, Willis Re said.Organizer：China Insura αnce Digital & AI Development 2020Web:h₩÷ttp://en.zenseegroup.com/p/560573/Contact:A↔≤ε™nn 021-65650305
Major information technology c§♥↔ompanies in India are running the risk of t♠≥γ$ermination of their $1 bil±≤γ↔lion contracts following ∏ Boeing Co.’s decision to ha ×<lt the production of Ω™its 737 Max jets, MoneyControl reported citing π↑∞the Business Standard. Companies like Tata →≤ΩConsultancy Services Ltd. ∑≠, Infosys Ltd., HCL Technolog≥$ies Ltd., Cyient Ltd. and L&T Technσ®₹✘ology Services Ltd. have outsourcin€★✔g contracts with Boeing or ÷→its suppliers and Boeing’s jet crisis is expec✘∞ted to affect these Iβ>"T companies in the short run.From:businessinsur♥α♦δanceOrganizer：China Insurance Digita®∞αl & AI Development 2020 Web:http://en.zenseegroup.com/p/560573☆>&/Contact:Ann 021-65650305
France-based eyewear ma"™ker Essilor International S.A. has discovered≤£ fraudulent activities at one of its factories€α¶ in Thailand that could cause €190 million ($21↑≤→¥3 million) in financial losses to the compaγ™ny, The Irish Times report→®ed citing Reuters. The ©®company has filed complaints in Thailand an♥×↑™d has fired all the involved employees. It h↕☆₩©opes to recover the losses from $™✘☆frozen bank accounts, insurance and lawsuits<₽λ.Organizer：China Insu☆★λrance Digital & AI Development 2020Web:http:/ ♠π/en.zenseegroup.com/p/560573/Conλ•÷tact:Ann 021-65650305
