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Prometheus Bioscienc¶™‍es, Inc., Enters Into M $εulti-Target Strategic Collaboration>‍✘♦ with Takeda to Develop Targeted Therapies σ♣λ​for Inflammatory Bowel Disease
2019-10-08

Prometheus Biosciences, I‍∑nc., a biopharmaceutical≠♣ company committed to the discovery<♦, development, and commercialization ×™of a broad portfolio of novel precision♠δ♦α therapeutics and companion diagnostics forβ→" patients living with unmet needs ★γ in gastroenterology an®♦​↔d autoimmune diseases, a<✔≥nnounced that it has entered into a global, multi& ↔₹-target strategic collaboration with Takeda ₩±Pharmaceutical Company Limited≠¥σ (Takeda) to discover, develop, and commercia©♦←lize novel therapies for inflammatoryλ☆σ bowel disease (IBD)Ω♥α. The collaboration combines ™¶λ←the proprietary bioinformatics discovery ₩®≥platform and companion diagnostic tools deπβ₩veloped by Prometheus Biosciences with×σ← Takeda's expertise in gastroenterol​♠ogy and drug development, in orde'₹r to discover and advance up to three t♣ ↕™argeted IBD therapeutics and companion$∑ diagnostics.  

Prometheus Biosciences ↕✘will be responsible fo ♦ ±r the identification and valida₽§®λtion of three unique drug targets for IB ¥≤↑D, along with the de ∑∑↑velopment and commercialization of compa¶‌nion diagnostics to coα×mplement the targeted drugs. Takeda will be r•®esponsible for all drug di✔♣scovery, clinical developmen∞>t, and commercialization activities f♠£©or the resulting targeted ≠™♣↕therapeutics.

"We are impressed with Taked$®​a's commitment to deve•×↓♠loping a portfolio of therapies to a™®±εddress all IBD patien©&≤ts, especially those ¶λ with unmet needs," said Mark McKenna, chief e $✔xecutive officer, Prometheus Biosφ↓εεciences.  "We believe that a targeted, p₹₹recision medicine approach is needed ₩₩↕♥to deliver new, effectiβ've therapeutic options in inflamma≈δ≤tory bowel disease. Through our partnership, we a≠✘✔↑re excited to combine the "'Prometheus bioinform×↓atics platform and advanced machine learning tech‌α→niques with Takeda's expertise in drug developm♠δent to deliver a new gδ‍eneration of IBD therapies."

Under the terms of the agre✔•©ement, Prometheus Biosciσ ‍≤ences will receive an undisclosed initial ←¥€upfront payment from Takeda and is eligi↓←ββble to receive up to $420M✔σ₹> in development, regulato↔™£ry, and commercial milestone payments, in↔  total, across all three programs. In additio$Ωn, Prometheus Biosciences&  is eligible to receive royalty payments on gl≤∏±obal commercial sales from each ©↔λprogram.

information source:pharma focus Asia

The original link:https:https://www.pharmafocδ→σ→usasia.com/news/prometheus-bios↔≤↔ciences-inc-enters-into≠¥γ∞-multi-target-strategic-collaboratio↕♦n-with-takeda-to-develop-tar×ε♣™geted-therapies-for-☆∑≈ inflammatory-bowel-disease

2019 Asia-pacific pharma IP Leader Summit: http://en.zenseegroup.com/p/510934/ will be held in Beijing  on November 14-15, and will attract more than 500 industry ex✘&★perts from domestic and forei"δ♠gn pharmaceutical companie♥‌$♥s, biotechnology companies, governments, assocΩΩiations, law firms, intellectual pαγ♠roperty agents and other $∞ε↑companies to attend.π✘

Official registration and consultatΩ∞×ion channels:

ContactAnn

Phone: 021-65650305

EmailMarketing@zenseegroup.com

http://en.zenseegroup.com/p/510934/

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From :businessinsuranceU.S. commercial properγ®ty/casualty rates rose 5% on aver☆✔age in the fourth quarter of 2019& ♣©, up from 4% in the third quar♣₹ter, reflecting insurers’ intenπ≠∑≠t to continue to increase p↔ ÷rices across most lines, online insurance eγ±xchange MarketScout Cor§>↕∑p. said Monday.“Auto rate increases have been u₽&∏p all year long; however D&O (directors &∞€amp; officers) and pr'★→ofessional rate increases have spiked £∞​significantly in the fourth quarter,” Richard ≥β₽↓Kerr, CEO of MarketScout Corp. said in a statπφement.Insurers are careful ‍ly analyzing their property exposures using ₩÷ catastrophe modeling tools, he said. “We expect ©★€many of the major propertβ§y catastrophe insurers ←≈←λto curtail their 2020 writings in California₹☆& brush and East and Gulf Coast←¥α© wind areas. Naturally, this will result in hλ®igher rates to insureds,™✘∑” Mr. Kerr said.D&O liability rates' ≥€ increased by 8.25%, while commercial auto incre§♥ γased 8% in the quarter, and professio≠ ©nal liability rates were up 6™ &%, and umbrella/excess rates were up 5.5%, $ according to MarketScout.Commercial property >♥×÷rates increased 5.25% in the quarter, ¶<and business interruption rates we₹↕re up 5%, while all other lines ÷£showed smaller increases, except ​ε$for workers compensation, where rates fell 1%,'δ MarketScout said.By industry class, transp→<✔ortation and habitational saw the highest averag±&e rate increases at 9% and 8.25% respec≥εtively, MarketScout sai​×βd.Large accounts – those with $250,001 to $1 mαα¶∞illion in premium – saw a rate ✔"™←hike of 5.5% in the four₹βφ↕th quarter, as did jumbo accounts, → which have more than $1 ₽₩million in premium. Small acc↕ α≤ounts – those with up to $25,000 in premium – ¶§were up 5%, while med•'ium accounts – those with $25,001 to $2'¶50,000 in premium – were up 4≈ §.5%.The “steady trend✔β” of upward rates reflects insur↓δers’ plans to continue increasingε  prices across all lines except for ↑¥workers compensation, MarketScout said♦δ ↕.Organizer:China Insurance Digital & A÷₹≤I Development 2020Web:htt☆&p://en.zenseegroup.com/p/560573/Contact:Ann 02↕↑1-65650305

From :insurancejournalIt was a relatively qσ©<uiet year for the Southeast in teβ↔≤≈rms of major catastrophes compared with 2018 wh≥£​en Hurricane’s Michae÷δ≥l and Florence caused major  Ω±↕damage in the region. This year,&nb‍♠ Ωsp;Hurricane Dorian si©↑‍≠deswiped the Southeast coast and made € landfall on the Outer Banks ofε‍₽ North Carolina but most of the a₹÷>rea was spared. Still, Aon said e≤≥conomic damage in the U.S. and Canada&←δnbsp;was poised to approach ₹∑​"a combined $1.5 billion.Flor‍→εida spent the year reco∑€♠≠vering from Hurricane Michael, which&nb¶‍sp;was upgraded to a ✘÷Category 5 storm by NOAA >÷in April. Florida officials have rep>✘eatedly called on the insurance industry to $♠σ‍speed up the recovery process, with nearlφ•y 12% of claims still open a year after the sto£$"rm hit.Organizer:China Insurance Digital >♦¶& AI Development 2020Web:http ←≈://en.zenseegroup.com/φ p/560573/Contact:Ann 02←β δ1-65650305

From:businessinsuranceeinsurance renewals at ‍®✔Jan. 1, 2020, mainly saw✘≈< single-digit increases, with some exceptions,≤↓β according to reports by reinsura ✔λβnce brokers released Thursday.Wil★¶lis Re, the reinsurance brokerage of↕∑₹ Willis Towers Watson PLC, and Guy Car‍<₹ penter & Co. LLC, a un ↔✘ it of Marsh & McLennan σδ Cos. Inc. both repor∞♣ted that year-end reinsu₹β₽rance renewals varied ♣$εby account and region, but the retroces™₩sional reinsurance was≠​ under pressure.Rates on line for pγ♥roperty catastrophe reinsu≈ β'rance programs remained stable a₹₩nd property per risk÷‌★ pricing was driven by indivi®Ω>★dual program performance, the Willis report sai✘®d.Although some Lloyd’s o∑δδλf London syndicates took firm•‍ positions on rate increases and t ₹he London market authorized ♦₹ capacity decreased, that capa☆λ‍¶ctiy was replaced by new cap₹↕'ital and a strong supply from→©≥ other markets, Willis Re said∞→←β.U.S. loss-free accounts <₽renewed at flat to up 1γ∑≈★0% while those with losses saw incr←₽​☆eases of 10% to 50%, the Wil÷₩☆lis Re report said, which was among ♥φthe largest increases. Property catasφ☆trophe accounts without losses renewed atε↓∏ flat to up 5%, while loss hit accoεΩ"unts were up 10% to 20%, Willis Re sσ •aid.According to the Guy Carpenter report, <↕​the brokerage’s global property ♣¶ catastrophe rate on line index rose 5% in 2 >∏019.According to the Willis Re repo✘↑εrt, other large increases were se¥&✘↑en in Central and Easter≥★δn Europe, where propert☆ •y programs with losses saw increases ∏≈•of 5% to 20%, and Canada, where su÷πΩch accounts renewed up 10% to 40​∞♠ε%.Most other regions and β>$countries saw proper→​©±ty increases in the single ↕$​or low double digits, the report said.The Jan♠¶$. 1 renewals saw some “♥§✘difficult” negotiations, a ₽ccording to a letter in t♥♥☆★he report from James Kent,Ω∑ global CEO, Willis Re.The Guy Carpente ©"¥r report said the re≥¶insurance market was “asymmetrical,” adding “t→ε÷"his is certainly not a one-size-fits-all mar★±πδket” and while overall capacity ☆±‍÷remained adequate, “allocated capacity tig"↕∞htened notably in stressed clas¥✘≈ses.”Dedicated reinsurance capital rose 2% in 2✔©≠"019 and the year saw approximately £ $60 billion in global insured catas'÷ ±trophe losses, according to Guy Carpenter,∞₹¶→ which was significant¥™©ly lower than 2017 and 201 ​8.Alternative capital, €φhowever, contracted by β‍£approximately 7% percent “as ''♠investors were more cautious with new investmen←±ts after assessing mark←λ≈et dynamics and pricing adequaα€cy,” Guy Carpenter said.The retrocession m♣$&arket “was challenged …₽↔δ→ by trapped capital, a >↑ "lack of new capital and continued re&←±demptions from third-party capital providersε•↑,” a statement issued with the Guy Carp↕♥enter report said.However, significa ♥☆nt retrocession providers return→♠ed to the market in the ∑♥ past two weeks, Willis Re sa∑♥id.Organizer:China Insurance Digital &πγαamp; AI Development 2020Web:http://en.zen∞÷seegroup.com/p/560573/Contact:Ann 02≠‌©♦1-65650305

Major information technology compan☆'↔ies in India are running the risk of term•πination of their $1 billion contracts fol↕£♠lowing Boeing Co.’s decision to h÷σ±​alt the production of its 737 Max jets, Mon∏→≈​eyControl reported citing the Business Stand✔™πard. Companies like Tata Consultancy Se€♣rvices Ltd., Infosys L₽→₹δtd., HCL Technologies Ltd., Cyient Ltd&™. and L&T Technology ServicΩ∑§es Ltd. have outsourcing↑♠ contracts with Boeing or its su✔$∑ppliers and Boeing’s jet crisis σ$↔★is expected to affect these IT companies in t>♥₹he short run.From:businessinsuranceOrganizer:Ch >ina Insurance Digital & AI Dev→∏elopment 2020Web:http://en.zenseeg☆♣roup.com/p/560573/Contact:Ann 021-65650305

France-based eyewear makerφ ≈ Essilor International S.A. has discovered frau←©dulent activities at one of ‌✔  its factories in Thail∏× ♦and that could cause €190 mi×≠☆♦llion ($213 million) in financial los•σ₽§ses to the company, The Irish Times re$ ported citing Reuters. The company has filed comp∑★<laints in Thailand and has fired al$→l the involved employe≈☆φes. It hopes to recover the losse↓£♣εs from frozen bank accounts, in∑♣β☆surance and lawsuits.Organizer:China Insurance ₩§ Digital & AI DeveΩ★<✔lopment 2020Web:http://en.zenε←§✔seegroup.com/p/560573/Contact:Ann 021-6565030'δ¥5

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