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- Ivy Brain Tumor Center and Bridφ£≥€geBio Subsidiary QED Therapeutics Announce Coll¶•aboration to Advance Canc®σΩer Research and Treatment Options
The Ivy Brain Tumor Center at Barro βw Neurological Institute, today announced¶σ₹ a new collaboration with Q→∞ED Therapeutics, Inc., a subsidiary of Bri♠γdgeBio Pharma, Inc., (Nasdaq:BBIO) toπ>↔ investigate the FGFR1-3 tyrosine kinase in↓¥ hibitor, infigratinib, for the t↕'♠βreatment of glioblast∏oma (GBM). With the goal of addressing unmet m↔$βedical needs for those affe'¥cted by malignant br≠εain cancer, this collaboration will foc<"•us on targeting FGFR π"©(fibroblast growth factor receptor) genetic alt≥∞©erations that have been shown to spur grα≠£♦owth in malignant tumors.
“Five to seven percent ≈€₽≥of glioblastoma patients’ tumor¥ s are driven by FGFR signaling,” said Dr. Nader "αSanai, director of the Ivy Brain Tumor Center. Ω<©≈“We believe our collaboration with QED Therapδ★•eutics will enable us to test how FGFR-dr₩≤iven GBM tumors respond to in™λπfigratinib. If proven effect∞φive, we then intend to move forward ne₽δδ↔w combined drug strategies incorp≠₹δorating this target.”
In the preclinical studies, the Ivy Center wi≈♥ll employ orthotopically implanted, well-∏§characterized FGFR3 fusion patient-derive♦λ>d xenograft models. This is intended to a ±δllow the team to furthe₩§r explore the extent t↑©o which the drug crosses the bloo ε↑¥d-brain barrier and what activityΩ it has in the brain.
“We believe the work we are undertak♣αing with the Ivy Center will provide critical i±♣βnsight to shape our clinical development strateg¶ ♣y for this disease,“φ> said Susan Moran, M.D.✔'♦, M.S.C.E., chief medic≤→¥al officer of QED Therapeutics. “↓♣&Our hope is that infigratinib wi↓¶$≠ll become the backbone of new combina§★§tion therapies to treat patients with gliobl♥σ↑astoma.”
Infigratinib is an orally administeredγ✔, FGFR1-3 selective tyrosine kinase inhibitor. Q®φED Therapeutics has observed ac©≤™tivity that appears to be meaningful in φ©clinical trials for cancers th≤∑≥δat are driven by errors in the FGFR genes.φ These include chemotherapy-refractory cholanπβ™giocarcinoma with FGFR2 fusions and advanced urot ™×helial carcinoma with FGFR3 gen€>©etic alterations.
“The intricacies of the brain have poεΩ§sed significant challenges for βbrain cancer research and the de÷ velopment of therapies,$” said Gary Li, head of translationΩ¶₹al medicine at QED Therapeutics↔÷. “We believe collaboβσ∑rating with the Ivy Brain Tumor Ce☆•™nter will enable us to move swi¶÷₩'ftly and further translational re✔¶&&search that we hope will uλnlock the doors to effective treatment÷ options.”
information source:pharma focus Asia
The original link:https:https://www.pharmafocusa&±Ω→sia.com/news/ivy-brain-tumor-center-and-bridgebio♠®-subsidiary-qed-therapeutics-announce-collabora₹♠tion-to-advance-cancer-research-a☆↔nd-treatment-options
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From :businessinsuranceU.Sα₹↑>. commercial property/casualty rates rose λ'5% on average in the fourth quarter✔Ω™∞ of 2019, up from 4% in ¥≈↔₹the third quarter, reflecting insurerδλs’ intent to continue to increase✘✔& prices across most lines, online insurance exch©✘ange MarketScout Cor'✔p. said Monday.“Auto rate increases have bee'∑n up all year long; however D&O (di×←≈₽rectors & officers) and ★ professional rate increases have spiked sigΩnificantly in the fourth quarter,” RΩ← ichard Kerr, CEO of MarketScout '∞εεCorp. said in a statement.Insurers are carefully "analyzing their property exposures using catastr∏πophe modeling tools, he said. “We expect many o$•♠f the major property cγ©γatastrophe insurers to curtail<βγ× their 2020 writings♣↔ in California brush and East and Gulf ↔σCoast wind areas. Naturally, this w&'ill result in higher rates to insureds,” Mr. Ker≠≤>£r said.D&O liability ↔↔rates increased by 8.25%, ♥σ₽ while commercial auto increased 8% in the q₩≥←☆uarter, and professional liab☆•¥ility rates were up 6%,£₩ε and umbrella/excess rates were up 5.5§>✔%, according to MarketScout.Comme¥∞§£rcial property rates increased 5.25%✔×→₽ in the quarter, and busine∏★ss interruption rates were up 5%, <£¶while all other lines showed smaller i<'↓$ncreases, except for worker ≥φs compensation, where rates fell 1%, Market£♣"Scout said.By industry class, transportation and ∑π∞habitational saw the γα₩€highest average rate increases at 9% and 8.2™•®↕5% respectively, MarketScout said.Large a®€÷≠ccounts – those with ₹↕$250,001 to $1 million in premium – saw a rate ↑α↓↑hike of 5.5% in the fourth quarter, as did ju<×∑mbo accounts, which have more than $1 §₹million in premium. Small a×≥'£ccounts – those with up to $25,000 in preφ≤mium – were up 5%, while medium accounts – th≤♥≥≤ose with $25,001 to $250,π♣"000 in premium – were up 4.5%.The “stead•<→§y trend” of upward rates reflects insur®ers’ plans to continue increasing prices across a' ll lines except for wΩ←∞"orkers compensation, MarketScout sai§λ™♥d.Organizer：China Ins>± €urance Digital & AI Develo∑pment 2020Web:http://en.zen× "seegroup.com/p/560573/Contact:Ann 021-65650305
From :insurancejournalIt was a relatively ↕$δquiet year for the Southeas≤σ≥₩t in terms of major catastrophes compared with ©γ©2018 when Hurricane’s Michael and Floren↑↕ce caused major damage in the region. Thisε∑¥ year, Hurricane Do♦∑§rian sideswiped the Southeast coast and m±≥×ade landfall on the Outer Bank±'s of North Carolina but most of tδδΩ←he area was spared. Still, Aon said ec$✘onomic damage in the &U.S. and Canada was poised to approα™ach a combined $1.5 billion.Florida spent the yea☆★♣r recovering from Hurricane Michael, whi≠≠™ch was upgraded to a Category 5 storm γ∏by NOAA in April. Florida officials hav ♣✘e repeatedly caδ£ ↔lled on the insurance industry to speed γ↔up the recovery process, with ne δ §arly 12% of claims still open a year after th∞φe storm hit.Organizer：₹™China Insurance Digital & AI Develop<§ment 2020Web:http://en.zenseegrou↔δγp.com/p/560573/Contact:Ann₽ α 021-65650305
From:businessinsuranceeinsurance renew≤×πals at Jan. 1, 2020, mainly saw ®σ✘€single-digit increases, with some exce★↓≤↓ptions, according to repor↔®♦"ts by reinsurance brokers released Thursday.←±$∞Willis Re, the reinsurance brokerag∞"e of Willis Towers Watson PLC, a≈↑<βnd Guy Carpenter & Co. →₹LLC, a unit of Marsh & McLennan Cos. Inc∏∞. both reported that year-end reinsurance rε☆αenewals varied by account and region, but th¶→÷e retrocessional reinsurance was under pr ♦₹essure.Rates on line for property cat↕εastrophe reinsurance programs remain ¶ed stable and property per risk pricing was dr≈δ←iven by individual program performaβ€nce, the Willis reporγε∏t said.Although some Lloyd’s of Lon↔ ©<don syndicates took firm positions on rate incr≈↔eases and the London ®market authorized ca∏±pacity decreased, that capactiy was replaced b 'y new capital and a strong supply from othe& ♦r markets, Willis Re said€↓.U.S. loss-free accounts renewed at flat to •>✘<up 10% while those with♥™ losses saw increases of 10% to 50%, the Willis R☆÷∞e report said, which wasε' among the largest increases.$↔✘ Property catastrophe accounts withoutπ☆ losses renewed at flat to up☆< 5%, while loss hit accounts § ≠were up 10% to 20%, Willis R¶ ∏Ωe said.According to the G"∑✘uy Carpenter report, the broker¥☆age’s global property catastrophe£♦±& rate on line index rose 5% iφ↓n 2019.According to the Willis Re re ¶port, other large increa∏&♥ses were seen in Central©< and Eastern Europe, where propeδ¥₽rty programs with losses saw increases of 5% to ↕$✘20%, and Canada, where§σ÷♥ such accounts renewed up 10% to 40%.Most oth∑<er regions and countries saw property increases ✔₽γin the single or low double digits, the repor€♣δt said.The Jan. 1 renewals s♦₹∑βaw some “difficult” negotiations✘ ♠€, according to a letter<β in the report from Jam™σes Kent, global CEO, Willis Re.The G'≈uy Carpenter report said the rei☆↕®♦nsurance market was “asymmetri∏€←cal,” adding “this is cer©₩§✘tainly not a one-size-fits-all market” and whiβ&le overall capacity remained adequate, “alloca¶β™∞ted capacity tightened notab÷ ✔ly in stressed classes.”Dedicated r↕λγ∏einsurance capital rose 2% in 2019 and the yea∏γε↓r saw approximately $60 billion in global ins>↑♥☆ured catastrophe losses, according to G£≠≤™uy Carpenter, which was significantly lowe♥×"≤r than 2017 and 2018.Al₹$ternative capital, however, cα¥ontracted by approximate φly 7% percent “as investors were♥≤ more cautious with new investments after asse≈↓ssing market dynamics and pricing adequacy,” ∞$≤Guy Carpenter said.T∑>εhe retrocession market “was challengedσ"→ … by trapped capital, a lack of new ca≥∏pital and continued redemptions from third-part↑ε£↕y capital providers,” a statement i£¶ssued with the Guy Carpenteγ♠r report said.However, significa∑∑'λnt retrocession providers ret§$₹urned to the market in the past two week&£≥€s, Willis Re said.Organizer↓∑β：China Insurance Digital & ↑♦♠amp; AI Development 20π↕Ω20Web:http://en.zenseegroup.com/p/5₩"'60573/Contact:Ann 021-656λ€50305
Major information technology companies in £↕India are running the risk of ter₹×π¥mination of their $1 billion contrac≈↕φts following Boeing Co.’s decision to ≠ "→halt the production of its 737 ☆✔Max jets, MoneyControl reportedγ≠ citing the Business Standarπ♠εd. Companies like Tata C♠αδonsultancy Services Ltd., Infosys Ltd., HCL Tecα"σβhnologies Ltd., Cyient Ltd. and L&T Techn★β¥ology Services Ltd. have outsourcing ™β"εcontracts with Boeing or its supplierΩα€s and Boeing’s jet cris¶αis is expected to affect these IT companie§✔s in the short run.Fr∞$om:businessinsuranceOrganizer：China Insu∏Ω"rance Digital & AI Development 2020™∑≤★Web:http://en.zenseegroup.com/p/560573/Contact:Anσ"'♣n 021-65650305
France-based eyewear maε÷<↕ker Essilor Internationa↑×l S.A. has discovered fraudu★≤εlent activities at one ofδ∏₹ its factories in Thaila☆&'☆nd that could cause €190 million ($213 mα'illion) in financial losses to the com♣☆pany, The Irish Times reported citing Re↔≥φεuters. The company has filed complaints in Thail₹λand and has fired all the involved emφ"ployees. It hopes to recover the lossesΩ > from frozen bank accounts, insurance and "εlawsuits.Organizer：China Insura&δnce Digital & AI Developme£↓nt 2020Web:http://en.zenseegroup.com/p/560573/Co©★ntact:Ann 021-65650305
