- Home
- News
- Industry news
- WindMIL Therapeutics aε nd University of California, Irvine Announ≥ce Collaboration to Collec≈αα¥t Bone Marrow from Patients with Glioma™s
WindMIL Therapeutics♠≈☆δ and University of California, Irvine Annou¶♥♣nce Collaboration to Collect Bone Ωλγ♣Marrow from Patients with Gliomas
WEDNESDAY, OCTOBER 16, 2019
WindMIL Therapeutics and'<÷ the University of Californ•↔βia, Irvine (UCI) today announced t < hat the first patients have been≠ identified in an invest÷≤Ωigator-sponsored study for the collection ofπ> bone marrow from patients with gliomas. T↕↔he study will evaluate generating marrow infiltr÷∑ating lymphocytes (MILs↔δ™) for these patients throu→₹₩÷gh WindMIL’s proprietary cellular activa€♥tion and expansion process. The stud→×♣₹y is being conducted at UCI.
“Patients suffering with glioblas☆©toma are in great need of new, promi$∏Ωsing treatments that might ∏γσΩadvance the current ∑Ωstandard of care,” said DΩλ>aniela A. Bota, MD, PhD, director of the UCI Heaα₩'lth Comprehensive Brain Tumor Program, senior€ ÷• associate dean for clinical res↓↕≠earch, UCI School of Medicine≥ δ∏ and clinical director, UCI Sue &αβ Bill Gross Stem Cell Research Cent©•♥→er. “The University of California™ ↓☆, Irvine is excited to play a key r±←ole in research that may lead t↑₽o a clinical trial that enlists the imm✔£✘une system in novel ways to fight this terrib∞le disease.”
Gliomas are the most common of the maligna↕¥€nt brain tumors. Glioblastoma, the most common <≈glioma, has a five-year survival of ≠≥≠φless than 5 percent. Additional≥π treatment options are u€≈rgently needed for these pat"&ients. Adoptive immunotherapy is a possib®le approach for gliomas and the use of MILs, a 䱩cell therapy that is natur↔≈ally tumor-specific, is one sucε'×h treatment option.
The bone marrow is a unique niche in the immune≥≤∏ system to which antigen-experienced memory§•×> T cells traffic and are then ma☆intained. WindMIL has developed a p₹"★roprietary process to select, activate and γ¶expand these memory T c$εσ∞ells into MILs. Because memory T♠§← cells in bone marrow occur as a result of ≤•±the immune system’s recognition of tu>π★₩mor antigens, MILs are specifically s↑₩π₹uited for adoptive cellular£λ immunotherapy and are able to♠±₹ directly eradicate or facilit→∏$™ate eradication of each patie♣φnt’s unique cancer. WindMIL is currently s÷ >↕tudying MILs in multiple myelo×βma, non-small cell lung cancer and squamous cel¶→l carcinoma of the head and neck,♦ ₽± and plans to expand iγ" nto other solid tumors. ∏
“WindMIL is looking forward↕∞" to working with the University of ♣€®&California, Irvine on thisα÷• exciting project and is optimistic that M™→§©ILs may offer the potential to help patients w䕧ith these hard-to-treat diseases♠ ®↑,” said Monil Shah, Pharm¥≈←D, MBA, Chief Development Officer at☆>★$ WindMIL.
information source:pharma focus Asi∏<a
The original link:https://www.pha♥™rmafocusasia.com/news/wi¶π✘ndmil-therapeutics-and-univers♣₩Ωity-of-california-irvine-announce-collaboratio ™n-to-collect-bone-marrow-from-patients-w± ith-gliomas
2019 Asia-pacific phar∏®ma IP Leader Summit: http://en.zenseegroup.com/™σp/510934/will be held in Beijing on November 14-15, and will attract mo↕¥re than 500 industry experts from domestic ←∞'≈and foreign pharmaceutical companπλies, biotechnology companies, gove &★rnments, associations, law f♣"irms, intellectual prπ ∞&operty agents and other companies to attend.Ω☆
Official registration and c±€¥δonsultation channels:
Contact：Ann
Phone: 021-65650305
From :businessinsuranceU.S. commercial pr$←≠operty/casualty rates rose 5% on ave ♦"↕rage in the fourth quarter of 2019, up from €≈π4% in the third quarter, reflecting insu ♠rers’ intent to continue to increase prices ♥ across most lines, online insur©<©ance exchange MarketScout C∏♠orp. said Monday.“Auto rate increases have be✘π&en up all year long; however D&O (di$ ≥®rectors & officers) an∞β$d professional rate increases have spiked si♠≤£gnificantly in the fourth q→"uarter,” Richard Kerr, C ✘π÷EO of MarketScout Corp. sa≈™☆Ωid in a statement.Insurer&≠©s are carefully analyzing their property δ∏exposures using catastrophe modeling tools, hασ×e said. “We expect many of the major prop₽÷™erty catastrophe insurers to curtail their 2♠∞020 writings in California¥γ brush and East and Gulf Coast wind are™"←₩as. Naturally, this will result <♠>in higher rates to insureds,♥✔≠” Mr. Kerr said.D&O liab≤'¥ility rates increased by 8.25%, while comm<♦ercial auto increased 8♠λ₹% in the quarter, and professional liabili÷δ÷λty rates were up 6%, and umbrella/excess ra₽φtes were up 5.5%, according to MarketSco£ →φut.Commercial property rates ✔∏increased 5.25% in the quar✘₽φter, and business inβ£terruption rates were ↓≥up 5%, while all other lines showed™&≈ smaller increases, except for worker↔≈s compensation, where ★φ£rates fell 1%, MarketScout said↕☆π≠.By industry class, transportation and¥→ε habitational saw the hi↕≠ghest average rate increases at 9% anβ↔©d 8.25% respectively, MarketSc×δout said.Large accounts – th←✘πose with $250,001 to $1 million in <¥premium – saw a rate hike of 5.5% in Ω>the fourth quarter, as did jumbo accounts, whicε₹γ₽h have more than $1 milli<≠€ on in premium. Small acco☆ unts – those with up to $25,00→₽✘β0 in premium – were up 5%, while medium acc↕∑☆♦ounts – those with $25,001 to $Ω→$250,000 in premium – we₽'<re up 4.5%.The “steady trend” of upward rates →✔reflects insurers’ plans to cγ<ontinue increasing prices across all lines excep§ t for workers compensation, Marke±¶ tScout said.Organizer：Ch↕¶≠ ina Insurance Digital & AI Developm<ent 2020Web:http://en.zenseeg™≤λroup.com/p/560573/Contact:Aβ Ωnn 021-65650305
From :insurancejournalIt was a relatively ±÷♣ quiet year for the Southeast in tΩ₩&erms of major catastrophes compared with 2018 whe>¶₩≠n Hurricane’s Michael and Florence caused maj£♣≥or damage in the region. This year, Hurri✘£cane Dorian sideswiped the Southeast coaγ→st and made landfall on the Ou×±ter Banks of North Carolina but mos★©¶t of the area was spared. St✘>€ill, Aon said economi©₽c damage in the U.S. and Canada&nb"™¥sp;was poised to approach a combined $1.5 bi π ∑llion.Florida spent the year recoveri™↓ ng from Hurricane Michael, which was upgr≥€≤σaded to a Category 5 storm by NOAA ↔<in April. Florida offi∑♥→cials have repeatedly cΩ•alled on the insurance industry to s♠↑αpeed up the recovery process,↔≥∑ with nearly 12% of claims still open a y πear after the storm hit.Organizerδδ★：China Insurance Digital & AI Devel↔÷opment 2020Web:http:/↑β /en.zenseegroup.com/p/560573/Contact:Ann 021-65650305
From:businessinsuranceeinsur✔©∏σance renewals at Jan. 1, 2020, mainly saw sin™÷Ω≤gle-digit increases, with some §✘exceptions, according to reports by reinsuranceφ'∏ brokers released Thursday.Willi ±♣s Re, the reinsurance brokerage of Willis T♠βowers Watson PLC, and Guy Carpenter & Co.↕£ LLC, a unit of Marsh &£÷♥λ; McLennan Cos. Inc. λ©both reported that year-end reinsurance rene>€π∑wals varied by account and region, but the ret∞↑rocessional reinsurance was under pressure.Rates Ω¶on line for property catastrophe reinsurance p∑•rograms remained stable and property per r₹↕Ω☆isk pricing was driven±✔ by individual program performance, →≠the Willis report said.Although ★±$some Lloyd’s of London syndicatπ∑"₹es took firm positions on rate increases an≈®d the London market authorized capacity d☆<©ecreased, that capactiy was repl ₩aced by new capital and a strong supply fוrom other markets, Willis Reλπ said.U.S. loss-free accounts renewed at fl↓♣↑at to up 10% while those wi☆•σ↑th losses saw increases of 10% to∑" 50%, the Willis Re repo∞'∏rt said, which was among the laα>←rgest increases. Property cata→♣strophe accounts without losses reneweβ"↑§d at flat to up 5%, wh®®ile loss hit accounts were up 10% to 20%, Willi←γs Re said.According to t$₽γ<he Guy Carpenter report, the broker₽±age’s global property catastrop←↓he rate on line index rose 5% in ∞≥↔2019.According to the Willis Re report, otherΩ♦ large increases were seen in Cent÷Ω¶ral and Eastern Europe, where prop₹↔♥erty programs with losses saw increases of ₩" 5% to 20%, and Canada, where such ac©ε$↑counts renewed up 10% to 40≈∑↓∞%.Most other regions and count♠✔ries saw property incr♣σeases in the single or low double digits, t¶¥he report said.The Jan. 1 renewals saw so>ασme “difficult” negotiatio≈¥ns, according to a letter in the report from Jameε₩∞£s Kent, global CEO, Willis♥≤♠ Re.The Guy Carpenter rγ©eport said the reinsurance market was “a± symmetrical,” adding “this is ceλγrtainly not a one-siz∏∑∏e-fits-all market” and while overall cap∏>&acity remained adequate®↕, “allocated capacity tightened notably in∏>$ stressed classes.”Dedicated reinsurance capitλσγ♣al rose 2% in 2019 and the♥→ year saw approximately $60α♠<¥ billion in global insure↔¶✘d catastrophe losses, according to Guy Carpente® ≥♦r, which was significantly lower than 2017 and 20φ↓£18.Alternative capital, however, contracted by ap★≥φproximately 7% percent “as investors ∞₽♣were more cautious with new investments aft₩er assessing market dy∑π☆namics and pricing adequacy,” Guy Carpenter sa♥★id.The retrocession market “was challenged … b≥± §y trapped capital, a lack of new ca→∑γ<pital and continued red↑♠emptions from third-paδ÷♣®rty capital providers★↓✘,” a statement issue≠♣☆&d with the Guy Carpenter report$¶¶₽ said.However, significant retrocession provid•≠ers returned to the market in the past t♥wo weeks, Willis Re said.Organizer：China Insuraφ©≤nce Digital & AI Development 2020Web:http://↕β•$en.zenseegroup.com/p/560573/Contacδ✔'t:Ann 021-65650305
Major information technology companies in India€∏ε are running the risk of termination of their $§&♠1 billion contracts following B¶✘₩↕oeing Co.’s decision to halt the∏™ production of its 737 Max jets, MoneΩ☆±yControl reported citing the ✘§ΩBusiness Standard. Companies like Ta ☆ta Consultancy Services Ltd., Info♠•Ω™sys Ltd., HCL Technologies Ltd., Cyie£©nt Ltd. and L&T Technology Services♦↕© Ltd. have outsourcing contracts with Bo®↕eing or its suppliersδ₽$¥ and Boeing’s jet crisis is expected t ✔o affect these IT comp✔☆♣☆anies in the short run.From:businessinsura✔β&nceOrganizer：China Insurance Digital & AI Dev≠σ←φelopment 2020Web:http://en.zeπ≠λ×nseegroup.com/p/560573/Contact:A&βnn 021-65650305
France-based eyewear maker ↔<ε€Essilor International S.A₹↕. has discovered fraud←ulent activities at one of its factories $±±in Thailand that could cause €1₩÷90 million ($213 million) in financial los ✔>ses to the company, The Irish Time↑≥s reported citing Reutersπ•. The company has filed complaints in Thailand a←"nd has fired all the involved employees. ☆×It hopes to recover the losses from frozen bank¥☆∞☆ accounts, insurance and lawsuits.Organizer：Chi✔$na Insurance Digital & AI Development 2020W∑'eb:http://en.zenseegroup.com/✘↓p/560573/Contact:Ann 021-6565030'>★5
