WEDNESDAY, OCTOBER 16, 2019
CRISPR Therapeutics, a biopharmaceutica✘β☆♦l company focused on creatin¥✘g transformative gene-base€<≠d medicines for serious diseases, andα§π KSQ Therapeutics, a biotechnology companδ↕y using CRISPR technology to enable the φ&"$company’s powerful drug dis$§covery engine to achieve higher probabilitiesσ₩ of success in drug development,φ<φ∞ today announced a license agreemenφ∑t whereby CRISPR Therapeuti×>"♣cs will gain access to KSQ₽ intellectual property (IP) f∏¥φor editing certain novel gene targets in its allo<✘↑geneic oncology cell therapy prograα>ms, and KSQ will gain access to CRISPR Therap★δ•eutics’ IP for editing novel genε Ωe targets identified by KS£♠Q as part of its current and future eTILT∏©★M (engineered tumor infil•✔∏trating lymphocyte) cell pr♠♠ograms. The financial terms of the agreem§¥ent are not being di→ sclosed.
“We are thrilled to g∏$∑∏ain access to CRISPR Th§↔♣★erapeutics’ foundational IP estate through this π agreement,” said David Meeker, M.D., Chief E₩>•xecutive Officer at KSQ Therapeutics. “Our eTILT♦€M programs involve edαΩiting gene targets in h$≠uman TILs that were discovered at KSQ by applyin $✔g our proprietary CRISPRomics® approach to immuδπ©ne cells in multiple in vivo models. <π®♠This agreement clears an important pβ ath for us to be able to ®α←bring these programs through development and comm≈₽★ercialization, lever↓₽♣aging CRISPR Therapeutics’ propriet≠♥±πary editing technology.”
The gene targets within the sco←<pe of the license agreement were identified using€♠∞© KSQ’s proprietary CRISPRomi±≈βcs® drug discovery engine, which allows genome®€✘-scale, in vivo valida€←ted, unbiased drug discovery. These specific ♣"•targets were uncovered in sc★™reens to identify genet↕ ≤ic edits that could enhance the functio'φ∞nality and quality of a©≠δdoptive cell therapies↕♣ in oncology.
“KSQ has built an industry-leading platformαα₽ to screen for novel gene targeε↔ts using its technology, and ha¶₩s identified a group of ¶∏targets that could help unlock the full ♦¥potential of adoptive cell therapy in oncol¥≈÷ogy,” said Samarth Kulkarni, βPh.D., Chief Executive Officer at CRISPR Therape≈α✔utics. “As a result of this license agreement, CR™φ€$ISPR Therapeutics will have the opporγ•☆©tunity to bring these novel targets inΩ® to our leading allogeneic CAR-T development☆ platform to further ¥♣↔♦strengthen our future programs in this important↕↔↕ therapeutic area.”
information source:pharma focus Asia
The original link:https:https://w♣↕δ✘ww.pharmafocusasia.com/news/crispr-therap∑₹eutics-and-ksq-therapeutics-announce-lice₩→nse-agreement-to-advance-companies-respeβ↑♠ctive-cell-therapy-programs-in-oncology
2019 Asia-pacific pharma IP Leader Summit: http://en.zenseegroup.com/p₹↑←/510934/ will be held in Beijing on November 14-15, and will attract more than ≥↓₽500 industry experts from $>domestic and foreign pharmaceutica$♥ ÷l companies, biotechnology companies,δ governments, associations, law firms, intellect€÷ual property agents and other compan£∏ies to attend.
Official registration an±↔♥d consultation channels:
Contact:Ann
Phone: 021-65650305
From :businessinsuranceU.>δS. commercial property/ca<₹÷∏sualty rates rose 5% on average in the fourt₽α∞h quarter of 2019, up from 4% in the t♦₩hird quarter, reflecting insu↑σrers’ intent to contin™♥♦σue to increase prices across m₽♦₩ost lines, online insurance excha><nge MarketScout Corp. said Monday.“Auto rate ¶π↓≠increases have been up all year l✔'♣ong; however D&O (directors & officers) aγ☆nd professional rate increases have spiked signif ↕€icantly in the fourth quarter,” Richard ₩↓Kerr, CEO of MarketScout Co₩rp. said in a statem±∑ent.Insurers are carefully analyzing their proper≥§ty exposures using catastrophe ¥→'modeling tools, he said. “We expect many✔¥ ↕ of the major property☆★£ catastrophe insurers to curtail their 2σδ020 writings in Californ "≈ia brush and East and Gulf Coast wind areas. ↑₩Naturally, this will ε result in higher rates to insureds,” ✔' Mr. Kerr said.D&O liability ≠λ✘rates increased by 8 ∏€≥.25%, while commercial aut♠αo increased 8% in the quarter, ∑®and professional liability rates wer₩↑e up 6%, and umbrella/excess rates<≠$ were up 5.5%, according to MarketScout.Comm<×ercial property rates increased 5.25% in t£≤he quarter, and business iβnterruption rates were αup 5%, while all other lines showe£♥εd smaller increases, except for wor<γ kers compensation, where rate♦ ✘s fell 1%, MarketScout said.By industry cla≈★Ω ss, transportation and habi✔>tational saw the highest average rate increase™s at 9% and 8.25% respectively, MarketScout sai↑d.Large accounts – those with $250,001 to ☆±₩$1 million in premium – saw a rate hike of γβ""5.5% in the fourth quarter, as did jumbo accounts™₽, which have more than $1 million →Ω'in premium. Small accounts ≈☆– those with up to $25,000 in premium – were u₹✘p 5%, while medium accounts – those with $25>★,001 to $250,000 in premiu♣£m – were up 4.5%.The “steady trend” ™"of upward rates reflects insurers"π'’ plans to continue increasing prices a✔↓cross all lines except f♦λαor workers compensation, MarketScout said.☆÷₹Organizer:China Insurance Digital φ★♦& AI Development&✘ 2020Web:http://en.zenseegroup.com ₩/p/560573/Contact:Ann 02→β α1-65650305
From :insurancejournalIt was a relat®≤ively quiet year for the Southeast ±'in terms of major catastrophes compared with ↓→→2018 when Hurricane’s<↓ ₩ Michael and Florence caused major ™φ♦'damage in the region →¶. This year, Hurricane ←×♦Dorian sideswiped the Southeast coast and m₹•↕ade landfall on the Oute≤§♦r Banks of North Caroli★σna but most of the area was spared. S®αtill, Aon said economic damage in th ™±e U.S. and Canada was poised ×↔£to approach a combined $1.5 billion.Florid£→a spent the year recovering from Hurricane M¶πichael, which was upgε∏€Ωraded to a Category 5 $λ←storm by NOAA in April. Flo✘≥<λrida officials have repeatedly called o✘$n the insurance industry to speed ✔§₩♥up the recovery process, with nearly 12% o®δ₩f claims still open a yearΩ♠φ✔ after the storm hit.Organiz∏∏✘er:China Insurance Digital & AI Dev™♣elopment 2020Web:http:/∏& ®/en.zenseegroup.com/p/560573/Contact:Ann 021-65£'α•650305
From:businessinsuranceeinsurance rene☆∞wals at Jan. 1, 2020, mainly saw single-γ∏digit increases, with<×φ☆ some exceptions, according to reports by reinsu≈rance brokers released Thursd≠✔§↕ay.Willis Re, the reinsurance brokerage of W±φillis Towers Watson PLC, and Guy Carpent✘®>er & Co. LLC, a un₩©it of Marsh & McLennan Cos. Inc. bot← λh reported that year¶& -end reinsurance renewals varied by account≥★ and region, but the retrocessional reins∞β" urance was under pressure.Rates on line foΩ✘★r property catastrophe reinsuran☆₽δ↕ce programs remained stable and propπ✔erty per risk pricing was driven by indivαφ ≥idual program performance, the Willis report >∞' said.Although some Lloyd’s of London syndicates ©∞≤took firm positions on rate in♣♠γcreases and the London market authorized capac♥ ∏ity decreased, that capactiy was re ®γplaced by new capita•φ✔σl and a strong supply from other markets≥↓Ω£, Willis Re said.U.S. loss-fre≤€ •e accounts renewed at flatφ☆ to up 10% while those with losses saw increasesφ of 10% to 50%, the Willis Re₽↔ report said, which was among the largest i¥♠₩ncreases. Property catastrophe accounts without↑≤¶> losses renewed at flat to up 5%±≤, while loss hit accounts wβere up 10% to 20%, Willis Re <♥★said.According to the Gα&uy Carpenter report, the brokerage’s g₩α®lobal property catastrophe rate on line index ros★&e 5% in 2019.According to the Willis Re report, o₽≤ther large increases were seen in Ce♥λ≤✔ntral and Eastern Eur& ope, where property programs with los®€δ÷ses saw increases of 5% to 20%, a₹ ↕&nd Canada, where such accounts renewed up 10% to ¥$®£40%.Most other regions and countries <←saw property increases in the single or low dπ€&®ouble digits, the report said.The Jan↔↕. 1 renewals saw some “difficult” negoπγtiations, according $×∑to a letter in the repor σ≥βt from James Kent, global ε↔CEO, Willis Re.The Guy Carpenter report s ♥®aid the reinsurance market was “asy÷¥ mmetrical,” adding “this i♦₽↕s certainly not a one-size-fits-all market” and $×"while overall capacity r✔✔↑♥emained adequate, “allocateπ↓₩d capacity tightened notably in♣σ'σ stressed classes.”Dedicated reinsuran™★♦ ce capital rose 2% in 2019 and the year saw app↔φ™roximately $60 billioφ✘n in global insured catastrop∏®¥he losses, according to€π Guy Carpenter, which was significantlyΩσ∞< lower than 2017 and 2018.Alternative™♦← capital, however, contracted¶× by approximately 7% percent “as investors were ♣§™more cautious with new investments afσ≈'ter assessing market dynamics aβββnd pricing adequacy,” G✔©$uy Carpenter said.The retrocession mα™arket “was challenged … by trapped capital, ±®φa lack of new capital and co÷₽ntinued redemptions from third-party caε≥ pital providers,” a sta®Ωtement issued with the Guy Car•↑✔✘penter report said.However, sign ±"φificant retrocession providers returned to the ↑σ€∏market in the past two w♥ "eeks, Willis Re said.Organizer:China Insurance "€♠←Digital & AI Developm✔ ↕↕ent 2020Web:http://en.zenseegroup.com/p/560573/C¶↔∞αontact:Ann 021-65650305
Major information tech✔¶↔ nology companies in India are running th∞≠"e risk of termination of their $1 billio↑ n contracts following Boei✔¶★∏ng Co.’s decision to halt the production o§≈f its 737 Max jets, MoneyControl reφλported citing the Business Standard. Companies λ like Tata Consultancy Services Ltd.≥α≈, Infosys Ltd., HCL Technologies Ltd., Cyient α&✔ Ltd. and L&T Technolo≥÷φgy Services Ltd. have outsourcing contra≈☆✔cts with Boeing or iγts suppliers and Boeing’s jet crisi↕₹γ≈s is expected to affect these IT₩↔ companies in the short run.Fro↔"m:businessinsuranceOrganizer:China In§↑surance Digital & AI Devδ∑$elopment 2020Web:http∑←://en.zenseegroup.com/p/560573/Contact:Ann 021-6®♣ 5650305
France-based eyewear maker Essilor Internatio←©nal S.A. has discovered fraudulent acti∑★vities at one of its factories iΩ∞×n Thailand that could cause €190 million ($2¶£$®13 million) in financial losses to the company, ≠÷The Irish Times reported ± citing Reuters. The company has filed co&♣mplaints in Thailand and has fired all the inv≠←olved employees. It hopes to recover t ₩∏♦he losses from frozen bank acco£↔unts, insurance and lawsuits.Organiz₽∑®er:China Insurance Digit¶±al & AI Development 2020Web:http://e↔×πn.zenseegroup.com/p/560573/Contacφ∏₩t:Ann 021-65650305