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- Shionogi enters into a new license agreement σ✔'and research collaboration for§£≥¥ the treatment of mycobac≠₽ terial diseases with Hσ£ siri Therapeutics, Inc.
Shionogi enters into a new license agreemen∑t and research collaboratio₩→n for the treatment of mycobacterial diseas÷'≤es with Hsiri Therapeutics, Inc.
MONDAY, OCTOBER 14, 2019
Shionogi & Co., Ltd. today announc∞™¥βed that it has entered into a new lic≥€≈ense agreement with Hsiri "₹×"Therapeutics, Inc. (Head Office: Media, PA, USA;>₽ President and CEO: William Cla&λ<ypool, M.D.; hereafter "Hsiri") regarding a≠& collaborative research an ≠d development program to discov↕πer and develop additional novel therape£εutics for non-tuberculous m♠•✘γycobacterial (NTM) diseases<∏ and tuberculosis (TB). This new ∞ ®collaboration will include technologπ↑"€y that complements Shionogi's♦ earlier collaboration arrangement with δ Hsiri.
The new technology to be↓™←' licensed from Hsiri has a novel mecha"φnism of action, will be complemen↑←tary to Shionogi's current research with Hsir∏ i, and is anticipated to be more effective than βα☆current therapies for mycobacteri•↑"§al infections. Shionogi's st ∑rength in small molecule drug di>♣∑scovery and development in the antibacteri←¥↔↔al area will support development of Hsirφ>•♦i's innovative therapeutics in♣♠ ¶ this collaborative program. Un≠♦↕der the terms of this agr¥eement, Shionogi will±×≥ have exclusive worldwide right♠®∏s to develop, manufacture, and commerciali≠↓ze the compounds generated©λ from the collaboration. Hsiri will receive an → upfront license fee, potential de≈©γvelopment milestones, a™€£nd royalty payments based on sales from₽← Shionogi.
It is reported that the number of patien®<φ↑ts suffering from NTM diseases ♣σεhas been increasing, especially in de±±veloped countries, in recent years. There ' ♦✔is a medical need to develop novel anti-NTM★σ drugs because of the long duration of t×↓φreatment and insufficient treat≤ש♠ment outcome of current therapeutλ∞ics. TB is one of the∞ three major infectious diseases in the world, an¥α✘d new cases of TB are estimated to be •←ε10.4 million/year. Multidrug-resistant TB (MDR- ¶ TB) and extensively drug-resistant TB (XDR-TB) h™×♠"ave become a major public health concer≠$≤n, and novel drugs for MDR-TB♠→ < and XDR-TB are anticipated.
Shionogi's research and deveγ∞>lopment targets infectious disease as one of its ↓☆priority areas, and Shionogi have positi oned "protecting peop£©≥le from the threat of infectious>≠α£ diseases" as one of its social ¥★mission targets. Through this coope¶↔↔ration, Shionogi strives coσ×₽αnstantly to bring forth§ innovative drugs for the treatment of infectiou "s diseases, to protect the health$φ'σ of patients we serve.
information source:pharma focus Asia
The original link:https:https:https://w™γ↑ww.pharmafocusasia.com/news/≤shionogi-enters-into-a-new-license-♦§λagreement-and-research-collaboration-for-the-trφ≥γeatment-of-mycobacterial-disea • ✘ses-with-hsiri-therapeuticσ's-inc
2019 Asia-pacific pharma IP Leader® ' Summit: http://en.zenseegroup.com/p/510934/ will be held in Beijing on November 14-15, and will attract more than 500 ↓'industry experts from domestic and foreign pha§ ≤rmaceutical companies, biotechnology com÷★panies, governments, ass≈γ"♠ociations, law firms, intellectua↔®→l property agents andσ₽✘ other companies to attend.
Official registration and consultat×∞ion channels:
Contact：Ann
Phone: 021-65650305
Email：Marketing@zenseegroup.com
http://en.zenseegroup.com/☆€p/510934/
From :businessinsuranceU.S. commercial →↔$property/casualty rates rose 5% on average in t← he fourth quarter of 2₹↓ 019, up from 4% in th♣↓↑☆e third quarter, reflecting insurers’ in ♦$tent to continue to i↑π↕ncrease prices across most lines, online insura™γ↓δnce exchange MarketScout Corp. said Monday.“←•$Auto rate increases have been up $£★all year long; however D&O (directors &↑≤'∏ officers) and professional ♠'×rate increases have spiked significant≈≠ly in the fourth quarter,” Richard Kerr, CE¶π O of MarketScout Corp. said in a statement.Insu$<$rers are carefully an→ alyzing their property exposures using catastr₩™↓ophe modeling tools,→€ he said. “We expect many of the majoπ∑$r property catastrophe in€↕surers to curtail their 2020 writings in Caliπ§∞fornia brush and East and Gulf Coast wi•€nd areas. Naturally, this will res≤σ♠βult in higher rates to insureds,” Mr. Kerr sa♦♠§id.D&O liability rates increased by 8.25%≈☆φ, while commercial auto inc©<♦reased 8% in the quarter, and professional liγεability rates were up 6%, and umbrella/exce×δ'ss rates were up 5.5%, according to Market≠↔Scout.Commercial property rates increased 5πγ↓'.25% in the quarter, and business interrup ¥ φtion rates were up 5%, while a✔$ll other lines showed smaller★§€↓ increases, except for workers compensatio>¶•₹n, where rates fell 1%, MarketScout said.By <₹πindustry class, transportation and habita<≠tional saw the highe st average rate increases at 9% and 8.2≥♠₽₩5% respectively, MarketScout said.Larδδ ge accounts – those with $250¶®,001 to $1 million i≈★¥♣n premium – saw a rate hike •÷of 5.5% in the fourth quarter, as diπφd jumbo accounts, which have more than $1 millionΩ®&' in premium. Small accountsγλ – those with up to $25,000 in premium – wer§×πe up 5%, while medium∞♠& accounts – those with $25,001 to $250,000 ™♠in premium – were up 4.5%.The £≠Ω“steady trend” of upward rates reflects insurers¶☆δ€’ plans to continue increasing pr§>ices across all lines except for workers coδ®≥mpensation, MarketScout said.Organize↕£r：China Insurance Digital & ✘ΩAI Development 2020Web:http:≠ε//en.zenseegroup.com/p/560573/Contact:Ann 021-6↓∞✔↑5650305
From :insurancejournalIt was a rel ₽★atively quiet year for theδ& Southeast in terms of major cat φ&"astrophes compared with 2018 when Hurricane★✔’s Michael and Florence caused major damage in∞∞ the region. This year, Hur≈✘♣ricane Dorian sideswiped the Southeast coast&n÷₹bsp;and made landfall on the Outer Banks of Nor✔σφ≠th Carolina but most of the area was spared. Stiσβll, Aon said economic damage in the U§×α.S. and Canada was poised to approach a c®λ¶ombined $1.5 billion.Florida s₽♠>pent the year recovering from Hurricane Micha₩€ ✘el, which was upgraded to a Category $φ§5 storm by NOAA in April. F∑♠φ"lorida officials have repeatedly >>λ;called on the insurδ≠$ance industry to spee∏♠λd up the recovery process, with nearly 12% of cla∑α∑ims still open a year after the storm hit.Or∞σganizer：China Insurance 〕 Digital & AI Developmeφ§nt 2020Web:http://en✔←$.zenseegroup.com/p/560573/Contact:Ann 021-656↑50305
From:businessinsuran™≠γceeinsurance renewals at Jan. 1, 2020, main×✘☆ly saw single-digit increase∏s, with some exceptionγπs, according to reports by reinsurance brok↕♥₩ers released Thursday.Willis Re, the reinε☆∞±surance brokerage of Willis Towers Wat✘ son PLC, and Guy Carpenter & Co. LLC, a u뮣nit of Marsh & McLennan Cos. In♦↔c. both reported tha≥♦∞γt year-end reinsurance renewals ₩↓≥varied by account and region,βε< but the retrocessio✘×€nal reinsurance was under pressure.Rates o£"n line for property catastr≈→ophe reinsurance programs remainαed stable and property per ri☆¶εsk pricing was driven by indiv♦'™ idual program performance, the Willis re×↑<'port said.Although some Lloyd’ ≥¥ s of London syndicates took firm posit♠$ions on rate increases and the Londo★♥₩n market authorized capacity decreased€φ, that capactiy was replaced by new capital a ©nd a strong supply from other mar↑♣kets, Willis Re said.U.S. loss-free accλ≥ounts renewed at flat to up 10% wh"$<ile those with losses saw§€♦φ increases of 10% to "¶50%, the Willis Re repor±¥$t said, which was among t™δhe largest increases. Pr'→operty catastrophe accounts without losε≥<ses renewed at flat to up 5%, whi★' le loss hit accounts were up 10% ≈ to 20%, Willis Re said.According to the Guy C¶φ₹arpenter report, the br™ ✘okerage’s global property catast€rophe rate on line index rose 5% in 2019.Accord✔©✔ing to the Willis Re report, other ÷'≈ large increases were seen in Central a δ Ωnd Eastern Europe, where p↕€roperty programs with losses saw increase$↕♥s of 5% to 20%, and Cana✔®da, where such accounts renewed up 10% to 40>♦%.Most other regions and countries €↔saw property increases in the single or low €↔↑double digits, the report said.The Jan. 1 r ₹enewals saw some “dif ©ficult” negotiations, according to a l ♦∞₩etter in the report from James Kent, global CEO • , Willis Re.The Guy Carpenter r±δeport said the reinsurance ≤♣÷✔market was “asymmetrical,” adding “this is cert☆↕★ainly not a one-size-fits-all market” a™φ✘nd while overall capacity remained adequa>λ≥te, “allocated capacity tightened notably in¥→ stressed classes.”Dedi £cated reinsurance capital rose 2% in § ≤ 2019 and the year saw approximately $60"λ"✔ billion in global insured catastro×'phe losses, according to Guy Carpenter, which w≈αΩas significantly lower than 2017 and 2018α&∏.Alternative capital, however, contrac αted by approximately 7% perc÷∞©ent “as investors were more cautious with new inv>€↑'estments after assessing market dynamics and ♦÷♠±pricing adequacy,” Guy ∞$εεCarpenter said.The retrocession mar✔≠±ket “was challenged … by t↓÷≠£rapped capital, a lack of new capit₽♣¶al and continued redemptions from ✔<third-party capital providers,” a statement i&β≠ssued with the Guy Carpente¶≈r report said.However, signif₩≈✔☆icant retrocession pr≠∞oviders returned to the market in the past tw♦←£o weeks, Willis Re said.Organizer：Chin>≥÷a Insurance Digital & AI Development 2020Web÷±δ:http://en.zenseegroup.com/p/560573/Contact:Ann≈§& 021-65650305
Major information te≠☆♠chnology companies in India are running the risk >↑✔of termination of th®♦ eir $1 billion contracts following ∞♠ ♣Boeing Co.’s decision to halt the producti<≥'÷on of its 737 Max jets, MoneyC→φ×∑ontrol reported citing the Business Sta≤"∞ndard. Companies lik☆₹®e Tata Consultancy Seφ>&♦rvices Ltd., Infosys Ltd., HCL Technol← ogies Ltd., Cyient Ltd. and L&T ∑Technology Services Ltd. have out✔≤•sourcing contracts with Boeing<∏ or its suppliers and ≥↕÷Boeing’s jet crisis is e∑$∑xpected to affect these IT companies in¶↕<× the short run.From:businessins∞ uranceOrganizer：China Insur→ ance Digital & AI Development 2020Web:http:/¶§✔/en.zenseegroup.com/p/560573/Contact:Ann ®<021-65650305
France-based eyewear m ±↑aker Essilor International S.A. has dis↕φcovered fraudulent ac÷λ¥tivities at one of it€γ✔♦s factories in Thailand that co∏∞≥★uld cause €190 million ($213 million) in finan×♥'★cial losses to the company, The Irish ←πTimes reported citing Reu÷ters. The company has filed c★γ↑ omplaints in Thailand and has fired all the invoβ§∞lved employees. It hopes to recover the losses f♠↑✘®rom frozen bank accounts, insurance and laε₹©wsuits.Organizer：China Insurance Digital &Ω↓γamp; AI Development 2020Webε×∑:http://en.zenseegroup.com/p/560573✘↔/Contact:Ann 021-65650305
