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- Advaxis and UCLA Enter Collaboration for Gliobl<$"♣astoma Immunotherapy Discovery Research
Advaxis and UCLA Enter Collaγ♠∑boration for Glioblastoma Immunotherapy Discoveryα∑§σ Research
FRIDAY, OCTOBER 11, 2019
Advaxis, Inc., a clinical-st£∏≥age biotechnology company focused on thδε↓e discovery, development and commercializatio>≤♠n of immunotherapy products, ♥£≈today announced a research collaboratio£n agreement with the University ofσ§ε California Los Angeles (Uλα®✘CLA) to conduct preclinical ¶λ£studies evaluating the Company’s Lm✔₩≤≠ technology in mouse tumor models of glioblastoma∏☆φ multiforme (GBM). Specifically, the collaborati↑₹on with Dr. Vaithi Aru>αmugaswami’s group at UCLA’s Department of &¥↑Molecular and Medical Pharmacology wilπσl investigate anti-tumor immunitγπ∏§y and anti-tumor respon₽♣ses generated by Lm vaccines that express diverseφδ glioblastoma neoantigens.
“We are excited that Dr. Arumug÷"γσaswami and his colleag×>δues at UCLA will investigate the po λtential of our Lm technology platform in♥✔ GBM, one of the deadlies£ t cancers,” said Andres Gutierrez, ↔ Executive Vice Presid★✔ent and Chief Medical Officer of Advaxis. “C↑λδontrary to other tumor↑£ types, GBM has not seen much succes←β•s in targeting by immunotπ↔ε$herapeutic agents due to ←∞a low tumor mutation burden, high tumoσ₹r heterogeneity and presen✘αce of the blood brain barrier, among§≠★' other factors. Hence, Dr. Arum✘↔ugaswami’s characterization of the neoantige★₽≠'n landscape and immune respons ©≠es to Lm- constructs may lead to the develo>≈ ≠pment of novel therapies with cli☆™₽≈nical activity in this elusive cancer.”
information source:pharma focus Asia
The original link:ht★∏tps:https:https://www.pharmafoc↔usasia.com/news/advaxis-and-ucla-enter-coll↑ ↕aboration-for-glioblastoma-immunotherapy-dσ✘iscovery-research
2019 Asia-pacific pharma I>®♥αP Leader Summit: http://en.zenseegroup.com/p/510934/will be held in Beijing on November 14-15, and will attract more than 500 industry experts ≤↓from domestic and foreign pharmaceutical≈ companies, biotechnε'ology companies, governments, associations, law≥α firms, intellectual property agents and•★ other companies to atten÷↑¥®d.
Official registration and♠±↔ consultation channels:
Contact：Ann
Phone: 021-65650305
From :businessinsuranc &♠eU.S. commercial property/casualty$↓ rates rose 5% on average in✔♣&↕ the fourth quarter of 2019, up from 4% i♦ε> n the third quarter, reflecting insurers’ inte÷¥ nt to continue to increase prices acros←σαs most lines, online insurance exδ∏♠change MarketScout Corp. said Monday.₹↕“Auto rate increases have been up all year lβΩ'ong; however D&O (d✘irectors & officers) and profession✘>€¥al rate increases have spiked ™↑→significantly in the fourth quaσ&±rter,” Richard Kerr, CEO of Market®λScout Corp. said in a state₩¥₽£ment.Insurers are carefully analyzing their prop™₩erty exposures using •≠πcatastrophe modeling tools, he ₽ said. “We expect many of the major←δ$ property catastrophe iα∏↑↑nsurers to curtail their 2020 writings in Califor÷₩>≠nia brush and East and Gulf Coast wind a♦₩Ωφreas. Naturally, this will result i€¥n higher rates to insureds,” Mr. Kerr s÷>$aid.D&O liability rates increased by 8.2$π§↓5%, while commercial ↓ auto increased 8% in≠₽ the quarter, and professional liability rates×€α were up 6%, and umbrella/excess←←©≥ rates were up 5.5%, according to MarketScout.Com"•®←mercial property rates increa☆§sed 5.25% in the quarter, and businesφ↓→€s interruption rates wer <π"e up 5%, while all other lines sho'§¥'wed smaller increases, except foα r workers compensatio'≈n, where rates fell 1%, MarketScout sa★>id.By industry class, tra¥βnsportation and habitatio≠"→nal saw the highest avε₩"βerage rate increases at 9% and 8.25% respective¶®ly, MarketScout said.Large accounts – those with δ$250,001 to $1 million in premium – saw a rate ₹φγhike of 5.5% in the fourth quarter, aγ®s did jumbo accounts, which have more than $1 mΩ∑illion in premium. Small accounts – thoseβ≥↓ with up to $25,000 in premium – w€♠ere up 5%, while medium accounts – those wit₹¶ ±h $25,001 to $250,000 in premium – were up 4.5%.λ♣≠×The “steady trend” of upwardαδ≠≈ rates reflects insurers’ planΩ s to continue increasing∞× prices across all lines except for w♥δorkers compensation, MarketScout ≈∑φsaid.Organizer：China Insurance☆¶ Digital & AI Development 2020Web:http://en.z✘'enseegroup.com/p/560573/Contact:Anσ★π♥n 021-65650305
From :insurancejournalIt was a relatively quiet ♥₹→year for the Southeast in terms of major cat>✔astrophes compared with 2018 when Hurricane✔₽’s Michael and Floren"₽✔ce caused major damage in the region. This yea©☆r, Hurricane Doriδ₽¶an sideswiped the Southeast coast and π₽♦made landfall on the ÷Outer Banks of North Carolina£∞α< but most of the area was sparedα♣≠δ. Still, Aon said economic ¥ α÷damage in the U.S. and ∞×Canada was poised to approach a c↓₽ombined $1.5 billion.Florida spent t£ he year recovering from Hurricane Michael, w←hich was upgraded to a Category 5 sto≤$→rm by NOAA in April. ₩σπFlorida officials have repeatedly called o£∏×n the insurance industry t←♦o speed up the recovery process,Ω•¶✘ with nearly 12% of claims s€€≠till open a year after t¶®he storm hit.Organizer：C↕₹φ'hina Insurance Digital & AI Dev↑σelopment 2020Web:http://en."♥zenseegroup.com/p/560573/Contact:Ann 0♠ 21-65650305
From:businessinsuranceeinsuran "¥ce renewals at Jan. 1, 2020, mainly saw±β single-digit increases, with some δ☆★∑exceptions, according to r★↑ eports by reinsurance brokers rele ∞♣☆ased Thursday.Willis Re, the reinsurance brokerag¥e of Willis Towers Watson PLC, and Guy Carpenter≠€© & Co. LLC, a unit of Ma≥♦rsh & McLennan Cos. Inc. both reported ★→>that year-end reinsurance renewal&↓s varied by account anλ®©d region, but the retrocessional rλαλeinsurance was under pressure.Rates on lin±•e for property catastrophe reinsurance programs ±∏remained stable and property per r £↓±isk pricing was driven by individual program per∏≈≈∑formance, the Willis report said.Although↑ ✘ some Lloyd’s of London s₩φ yndicates took firm positions on rγα>ate increases and the London mar±® ket authorized capacity decreased, that capacti≥β★'y was replaced by new c§↔apital and a strong suppl∑ y from other markets, Willis Re saiεd.U.S. loss-free accounts renewed at flat to γup 10% while those with losses sa→♠₩∞w increases of 10% to 50%, the₩ Willis Re report said, which was among♥☆ the largest increases. Prop>β•erty catastrophe accounts without losses renewe≤d at flat to up 5%, whil✘ §€e loss hit accounts were up 10♠•% to 20%, Willis Re said.Accordin←g to the Guy Carpenter report,✘★ the brokerage’s global property cat ←♠astrophe rate on line index rose 5§ε∑€% in 2019.According to the ©π∑Willis Re report, other large increases&" were seen in Central and Eastern Europe, where ©α↓®property programs with losses ±↔φεsaw increases of 5% to 20%, a♣→∏nd Canada, where such accoun↓←ts renewed up 10% to 40%.M£♣ost other regions and£₹β♠ countries saw property incσ♣reases in the single or low double digits, ∞♣φthe report said.The Janβ®γ∞. 1 renewals saw some “difficult” negotiations,™• according to a letter in the report from James Kπ¥÷ent, global CEO, Willis Re.The Guy Carpentβδ←₩er report said the reinsurance market was “asymmeαβ←trical,” adding “this is certainly not ₽• a one-size-fits-all m÷≥βarket” and while overall capacity ↑₩®↑remained adequate, “allocatγ∏ed capacity tightened notably in£ ©α stressed classes.”Dedicated reinsurance cap׶₽ital rose 2% in 2019™☆× and the year saw approximately $60 bil♥♠&¥lion in global insured catastrophe losses, a↕©¥ccording to Guy Carpenter, which wγ ♣§as significantly lower th® ©≈an 2017 and 2018.Alternativ<£$÷e capital, however, contracted by appr≠↔♥oximately 7% percent “as invλ∏estors were more cauti↑♠₽→ous with new investments after as↕₽¶>sessing market dynamics and"€×✔ pricing adequacy,” Guy Carpenter&€×± said.The retrocession market “was challeng∏✔ed … by trapped capital, a lack of new capit÷&¶∞al and continued redem≠↔✘ptions from third-party capital providers,”€♣ a statement issued with£≥₽ the Guy Carpenter report said₽λ©.However, significant retrocession p≤ ¶¥roviders returned to<☆♣ the market in the past t↕✔•φwo weeks, Willis Re said.∑☆Organizer：China Insurance Digital & AI Dev≈elopment 2020Web:http://en.zen>÷≠ seegroup.com/p/560573'♦/Contact:Ann 021-65650305
Major information technolo₽&gy companies in India are running the risk of ter↕↓ mination of their $1 billion contra •cts following Boeing Co.’s decision to h<☆π↑alt the production of its 737 Max jets, MoneyCont∞↔rol reported citing the Business Standard. Compπ↕≥πanies like Tata Consultancy ServicesΩα Ltd., Infosys Ltd., HCL Technologies Lt←≈$πd., Cyient Ltd. and ♥✔L&T Technology Services Ltd. have outsou★rcing contracts with Boeing or its sup£$↕pliers and Boeing’s jet crisis is expected to ∑γaffect these IT companδ♦ies in the short run.Fr♠$£om:businessinsuranceOrganizer：China♠§≥ Insurance Digital & AI Developmen↑→✔∑t 2020Web:http://en.zenseegroup.com/p/560573♠✘/Contact:Ann 021-65650305
France-based eyewear maker Essilor InΩ₩ternational S.A. has discove< red fraudulent activities at one of its fact∑÷ories in Thailand that could cause ¥×σ€190 million ($213 million) in financial l" osses to the company, The I☆&©Ωrish Times reported citing Reuters. T♥δhe company has filed complaints in Th↔✘ailand and has fired all the involved empl™€oyees. It hopes to recover the losses from froze£'≥n bank accounts, insurance ±÷>and lawsuits.Organizer：China Insur×₽®ance Digital & AI Development 202 ☆₩0Web:http://en.zenseegrou₽"p.com/p/560573/Contact:Ann 021-65650305
