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- Goldfinch Bio Announces Licensing Agreemλ₩ent with Takeda for ↔≥₹™CB1 Monoclonal Antibody for the Treatment of Rare÷∑ and Metabolic Kidney Di∞→seases
Goldfinch Bio, a U.S.-based, clinical stage b☆γ iotechnology company focused on↕↕♠ discovering and developing pr<≈≥ecision medicines for the treatment of kid↑<ney diseases, today announced it entered into a ε♣∑license agreement with Ta α✔keda Pharmaceutical Company Limited (“Ta¥♦¶☆keda”) for worldwide rights to a prec♣& linical, peripherally-re©™✔stricted cannabinoid receptor 1 (CB1) monoclonal ♣♠→antibody. Goldfinch Bio will assume all€φ development and comm£∞↑§ercialization responsibilities for the t& &±reatment of rare and metabolic kidney disease♠&£s worldwide. However, the agreement grδ₩®Ωants Takeda the option, prior to ∏φthe initiation of pivotal studies, to requ"'<↓est Goldfinch Bio negotiate wi✔£₽₹th Takeda for sub-lice¥↓✔nsing of Japanese right®σ&s to Takeda. Financial terms of the agreement w&∞ere not disclosed. Goldfinch Bio plan♠Ω☆s to file an investigation♠al new drug (IND) application for this CB1 in™♥ε≤hibitor, re-named GFB-024, in the second ↓♣half of 2020.
“In recent years, our understanding of t"÷he role of CB1 signaling in exacerbating progress✘÷ive kidney diseases &σ'≠has grown substantiall★&± y. In this context, a monoclo∞≈αγnal antibody directed to∏©♠ward the CB1 receptor is potΩ$£≠entially well-suited to elicit the beneficial€∏ pharmacology associated w§"≈↕ith the peripheral inhibition of the C" ε♠B1 receptor,” said Anthony Johnson, M.D., Pres∑δ¶ident and Chief Executive ☆πγ≥Officer of Goldfinch Bio. “Goε≥±ldfinch Bio will deploy Ωγ≤¥its biology platform and Kidney Genome ↔↓♥AtlasTM to develop this therapeutic agent in subs✔"ets of patients with kidney disease♣∏πβs most likely to preferentially respon™α¥d to CB1 inhibition. With GFB-8→γ87, our TRPC5 inhibitor for FSGS, in Phase 1 c'₹★₹linical development, this peripheral CB1 inhibi£₹tor will be the second clinic-ready program in ∏≤Goldfinch Bio’s pipeline. W↓☆↔&e look forward to collaborating wit γβh Takeda on this program.”
“Goldfinch Bio is ideally suite>•♣∞d to advance development of this program,” said ε>✘★Dan Curran, M.D., SVP and Head, Rare Diseases The←↑← rapeutic Area Unit, Takeda. “The application o<♠✔f its precision medicine approach, from cand÷₽← idate target validation th¥↔£&rough to identification o ±f potential treatment-relevant↑γ subgroups, is unique in δ♣the development of chronic metabolic kidney disea✔"♦se treatments.”
Preclinical data support ±Ω the inhibition of CB1 signaling as™¥α a novel treatment of Diabetic Nephr∞ opathy (DN) and obesity-related glomer₽≠₩λulopathies (ORG), given the potentia₹ l metabolic benefits and direct effects ♣≤± on the kidney to prevent fibroδ≤sis and preserve kidney function. ∏€★βDN develops in 30 to 40 percent of patients who ★♠have diabetes and is a le×≤€€ading cause of morbidity, mortality and end-stage↓ kidney disease in the United States and worldw ¶ide. ORG is a rare kidney disorde♥α™r characterized by significant∑<δ proteinuria and progressive renal dysfunct©∑ion. Although both DN and ORG are increa£×&sing in prevalence in parallel with the obesו©ity epidemic, well-establis≈∞ ∞hed disease modifying therapies are lacki•÷ ng. Goldfinch Bio plans to initiate a phase 1 stε←πudy for GFB-024 in 2H 2020.
information source:pharma focus Asia
The original link:https://www.pharma✘σfocusasia.com/news/goldfinch-bio-announces-licens&∞↕ing-agreement-with-takeda-©'λfor-cb1-monoclonal-antibody-for-the-t₹✔&σreatment-of-rare-and-metabδ☆olic-kidney-diseases
2019 Asia-pacific pharma IP Leadeε←Ω r Summit: http://en.zenseegroup.co↕→✔¥m/p/404716/ will be held in Beijing on November 14-15, and will attract moπ£re than 500 industry exp♠✔erts from domestic and for←∞≈eign pharmaceutical companies, bioβ≥≠ technology companies, governments, associations,<✔•₹ law firms, intellectual ∞ £σproperty agents and other companies to&↑ attend.
Official registration and consultation chaασnnels:
Contact：Ann
Phone: 021-65650305
From :businessinsuranceU.S. commerci<€€al property/casualty rates rose 5%✔§ ¶ on average in the fourth quar ↕$ter of 2019, up from 4% in the third qua↕'λrter, reflecting insurers’ intent to continu"♥∞e to increase prices across most lπ↔¥ines, online insurance exchange MarketS'¥cout Corp. said Monday.“Auto rate increases★ have been up all yeaδ×∞r long; however D&O (direc∑☆ σtors & officers)Ωε and professional rate increases have spiked signεificantly in the fou"≠φrth quarter,” Richard Kerr, CEO of ΩMarketScout Corp. said in a statement.Insurers λ are carefully analyzing their property >∑exposures using catastr←←☆ophe modeling tools, he said. “We eΩ€←xpect many of the major prope£$rty catastrophe insurers to curtail their 2020 w×>ritings in California brush and East and←> ↓ Gulf Coast wind areas. Naturally, this w™<ill result in higher rates to insureds,” Mr.∞β± Kerr said.D&O liability r↔•©♦ates increased by 8.25%, while com≈★φmercial auto increased 8% in the quarter, and pro←¶¶fessional liability rates were up 6%, and >¥λumbrella/excess rates were up 5.5%,₽♠ according to MarketScout.Commerciσ≤•al property rates increased 5.25% in the q☆♣•uarter, and business interruption rates were up ♣5%, while all other lines©™ showed smaller increases, exc ±♥ept for workers compensation, where rates felσ≤l 1%, MarketScout said.By indusΩtry class, transportation a≈"π♦nd habitational saw the highest average r₽∑ate increases at 9% and 8.25% respecti ≠↑εvely, MarketScout said.L₩¥"arge accounts – those with $"÷♣÷250,001 to $1 million in premi um – saw a rate hike of↕>"ε 5.5% in the fourth quar®₩ter, as did jumbo accounts, ↔λwhich have more than $1 million in premium. Small∏ δ accounts – those with up ×♠ ♠to $25,000 in premium – were up 5%, while medium←Ω≥ accounts – those with $25,001 ≥® to $250,000 in premium – were up 4∑♦&.5%.The “steady trend” of upw♠λard rates reflects in÷surers’ plans to continue inc•≠♦reasing prices across all lines except ≈©®€for workers compensation, MarketScou∏>×t said.Organizer：Chi✘™na Insurance Digital &amε ↕p; AI Development 2020We₩★b:http://en.zenseegroup.com/p/560573/Co™∞ntact:Ann 021-65650305
From :insurancejournalIt was a relatively qui¥&✘&et year for the Southeast in terms ofβ∞ major catastrophes compared with 2018 wh←≠☆©en Hurricane’s Michael an¶₽☆d Florence caused major damage in the region. Th©σ₩₩is year, Hurricane Dorian sideswipedσ¶ the Southeast coast&nbφ÷®"sp;and made landfall on the Outer Banks of Nor¶∞£♠th Carolina but most of the area was sp₽₹₹ared. Still, Aon said §&≠>economic damage in the U.S. and Canada was> ≠ poised to approach a combined $1.5 bi©★₹→llion.Florida spent t<σ<he year recovering from Hurricane Michae✔∑l, which was up≠₩graded to a Category≠¶ 5 storm by NOAA in April. Florida offic→αials have repeatedly called on the insuran"π↕ce industry to speed up the recovery< ♦ process, with nearly 12% of cl£₽★aims still open a year after the storm hit.Or≠•ganizer：China Insurance Digitaφεπ÷l & AI Development 2020Web:http://♠ en.zenseegroup.com/p/560573/Contact:Ann 021-65650φ$δ305
From:businessinsuranceeinsurance renewals at Jan<₩↑. 1, 2020, mainly sawσφ single-digit increases,∏♣ with some exceptionsσ♣$¥, according to reports by reinsurance broke♦<rs released Thursday.Willis Re, the reinsur↔αance brokerage of Willis T<&"λowers Watson PLC, and Guy Carpenter & Co. ε"LLC, a unit of Marsh & McLennan Cos. Inc. boα₽th reported that year-end reinsσ£≤urance renewals varied by∞≈Ω♠ account and region, but ≠&→∏the retrocessional reinsurance ←✘®was under pressure.Rates on line fo¶£εr property catastrophe ♦♦↓£reinsurance programs remained stable a ≤nd property per risk pricing was driven ≤≈by individual program performan¶®∏ce, the Willis report said.Although some Lloyd’sε×₹♠ of London syndicates to≈δγok firm positions on rate₽→ increases and the London market authorized✔σ capacity decreased, that caπ®✘pactiy was replaced by new ©≈capital and a strong supply from othe₽∏₽r markets, Willis Re said.U.S. loss-free accounts$→> renewed at flat to up 10% while t™₹★hose with losses saw increases of 10% to 50♥®✘%, the Willis Re report said, which wπas among the largest increases. Property ca±♥¥tastrophe accounts without losses ™γ♦•renewed at flat to up 5%, while loss hit accoun→δts were up 10% to 20%, Willis Re ≠★said.According to the Guy Carpenter report, ¶♥★the brokerage’s global proper★ ty catastrophe rate on line index rose 5% in 20'←π19.According to the Willis Re report, other£♥™ large increases were seen inπ™ Central and Eastern Europe, where property prog✘ ↕rams with losses saw increases of 5% t®÷o 20%, and Canada, w÷×'here such accounts r× enewed up 10% to 40%.Most other regi→Ωons and countries saw property increases ♥✘☆≤in the single or low double digits, the rep××>ort said.The Jan. 1 renewals saw some “diff✔≈< icult” negotiations, according to a l×→←etter in the report from Jame♠s Kent, global CEO, ™>∏Willis Re.The Guy Carpe'λ↕nter report said the reinsurance mark♥∞et was “asymmetrical,↔™¶” adding “this is certainly not a one♦♣-size-fits-all market” an™≤d while overall capacity remained adequa→∑γ→te, “allocated capacity tight♦ ened notably in stressed classes.”Dedicated ±δreinsurance capital rose 2% in 20 ™↓"19 and the year saw approxi₽¶λ×mately $60 billion in global insu$εred catastrophe losses, accordin→∑←♦g to Guy Carpenter, wh∏¥ich was significantly lowe×÷<r than 2017 and 2018.Alt∞'>>ernative capital, however, contractedπ by approximately 7% percent “aε•s investors were more cau λ♣≤tious with new investments after assessing ma÷σrket dynamics and pricingσ₹ adequacy,” Guy Carpenter said.TΩεδhe retrocession market “was challengeβ£d … by trapped capital, a la$λ←ck of new capital and continued redemp¶tions from third-part ↔¥≈y capital providers,” a stat© Ωement issued with the Guy Carpenter ✔ report said.However, significa←♦<nt retrocession providers return→≠±ed to the market in the past two weeks, ∑₹Ω Willis Re said.Organizer：China Insurance Digital™λ & AI Development 2020Web:h≤ttp://en.zenseegroup.com/p/5 ≠♦✔60573/Contact:Ann 021-65650305
Major information teδchnology companies in India are ε ↔running the risk of termination of § >★their $1 billion contracts f÷≠ollowing Boeing Co.’s deci©αsion to halt the pro§→duction of its 737 Max jets, MoneyContα↕™rol reported citing the Business Standard. Compan ↕♥₹ies like Tata Consultancy Servi₩<ces Ltd., Infosys Ltd., HCL Technologies Ltd.® ♠, Cyient Ltd. and L&T Technology Services Ltdπφ♣. have outsourcing contr☆∞ ∏acts with Boeing or its supp¶↔♣σliers and Boeing’s jet crisis is expec≤Ωted to affect these IT comλ©panies in the short run.From:busi§ ☆εnessinsuranceOrganizer↔↑&★：China Insurance Digital & AI Developmentσβ 2020Web:http://en.zenseegroγπup.com/p/560573/Contac £t:Ann 021-65650305
France-based eyewear maker Eγ≈ssilor International S.A. has↔→÷≤ discovered fraudulent activiti≥↔es at one of its fact×¥π∑ories in Thailand that♦& could cause €190 million ($213 milli£♣™™on) in financial losses t✔α✘o the company, The Iris≠✔←h Times reported citing Reuters. Thαe company has filed complασ♦ aints in Thailand and has fired all t≥↕γ&he involved employees. It hopes to recoverγ" the losses from frozen bank ¥₹ accounts, insurance and lawsuits.Or♣•Ωganizer：China Insurance Digital & AI De☆♥∑velopment 2020Web:http://en.zenseegroup.c<✘om/p/560573/Contact:An♥☆≥n 021-65650305
