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4D Pharma collabor4D Pharma collaboraδ™©↕tes with MSD to develop live biotherapeutic pr'™→oducts for vaccinesates with MSD to develop 'φlive biotherapeutic pr♠$∞≤oducts for vaccines
2019-10-10

4D pharma plc, a leading pharmaceutical co<★®mpany in the development of live biot☆×γherapeutics, today annou§★nces that the company has ente§₽→red into a research collaboration agreement and a↓©©✔n option license to use with MSD (trading nam₹ε&£e of Merck & Co., Inc., in Kenilworth₹₹ , New Jersey , United States of Am♦¥≠erica) to Discover and Develop Live Bi£×♠↕otherapeutic Products ("LBP") for vaccines.

Under the terms of the agreement, MicroRx®, theπ₩© proprietary platform of 4↑©≠D, will be associated with MSD's expertise in t ↕he development and comme×₹rcialization of new vaccines, inε≤ order to discover and develop LPBs as vaccin¶"™£es in maximum three ↓¶undisclosed indications. &π♥←4D has the right, subject to₽γ‌ certain conditions,♣®π× to purchase from MSD for $ 5 millio'≤←•n common shares of 4D during th♥ <©e first 12 months of the colπφεlaboration. In addition to an initial cash pa↔¥•yment, for each indication, 4D will be eligib☆↕le to receive up to φ©$ 347.5 million in exercis€★÷£e of options and regulatory and devel∏γ→opment milestone payme£ ₩™nts, as well as royaltie•♣™s the annual net sales of any licensed pro®₹duct resulting from th←★§•e collaboration.

Duncan Peyton , CEO of 4D, said, "This collabo'εrative research agreement bring×‍s together 4D's innovati→>ons in the microbiome field ≠✔and MSD's track record in the devel✘γ↓opment of advanced vacci •nes. MSD and 4D worked closely together comb‌←ining world-class sci∏ו®entific knowledge to develop →δa work plan to advan★σce understanding of this field, with the goal ©φof generating a new class©'¥ of vaccines in areas where γ♣ unmet needs are important. "

Daria Hazuda , Scientific Director of>¶↔ MSD's Exploratory Scie<←©nce Center and Vice Prβ★esident of Research on MSD's Infectious Dise↕δ€ ases and Vaccines Disc♥✘overy, said, "A key element of our goal ♣€€at the Center for Ex₹£‌<ploratory Science is the ✘ α€assessment of emerging γ™±areas of emerging biology that ≥£are likely to have a major beneficial impa₩επct on human health. By applying Mic¶×§roRx® technology of 4D, α∏we hope to obtain usefulλ₽✘↑ information on the role of the host microbiome≤→✔♣ in modulating the immune response anε​d, ultimately, the proteπ♣​≠ction conferred by vaccines. "

information source:pharma focus Asia

The original link:https:https://www뱩.pharmafocusasia.com/news/4d-pharma-₩☆collaborates-with-msd-to-develop-live-↑♠​biotherapeutic-products-for-vaccines

2019 Asia-pacific pharma IP Leade♣λ✘φr Summit: http://en.zenseegroup.com/p/510 ♦€934/will be held in Beijing  on November 14-15, and will attract more t₩'§₹han 500 industry experts from doε∑mestic and foreign pharmaceutical compa¥→ nies, biotechnology companies, gover≤€≤ nments, associations, law firms, intellec∑ ₩tual property agents and ot ↕her companies to attend.

Official registration and consultation↕±&✔ channels:

ContactAnn

Phone: 021-65650305

EmailMarketing@zenseegroup.com

http://en.zenseegroupπλ≠.com/p/510934/


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From :businessinsuranceU.S. commercial propert₽₹÷y/casualty rates rose✔≠± 5% on average in the fourth quarter of 2019, u ×↑p from 4% in the third q¥λ∏uarter, reflecting insurers’ intent©₩ to continue to increase prices across most line↕¥s, online insurance exchange MarketScout Cor₽↑'p. said Monday.“Auto≥≤•♣ rate increases have bee•✔εn up all year long; howe™¶÷ ver D&O (directors & o£≈₽✘fficers) and professional rate i±¶ncreases have spiked significa""ntly in the fourth q₽ uarter,” Richard Kerr, CEO of MarketSc↑≠out Corp. said in a statement.I©€§nsurers are carefully analyzi<¶ng their property exposures using c∏'∞​atastrophe modeling tools, he said. “♣®≈We expect many of the major property catasπ×®πtrophe insurers to curtail their 2020 writ≠★∑£ings in California brush and East and÷γ₩' Gulf Coast wind areas. Naturally, this wiπ₽ll result in higher rates to insureds,” Mr. Kerr ¶≠♦÷said.D&O liabili→↓♦§ty rates increased by 8.25%, while commercσ↑ ial auto increased 8% in the ¥∞​quarter, and professional liability rates were u♦ 'p 6%, and umbrella/excess rates wer≥ e up 5.5%, according€σ♣‌ to MarketScout.Commercial property rat​✔↓‍es increased 5.25% in the quarter, and business×™✘ interruption rates were up 5%, while all otherφ₽≤× lines showed smaller increases, except for w✘↑≠λorkers compensation, where rate↓©×s fell 1%, MarketScout said.By industry class, tr₩εΩansportation and habitational ≤$≠saw the highest average rate increases at 9% a>¶∞'nd 8.25% respectively, Ma₽↕λrketScout said.Large accounts – th÷©ose with $250,001 to $¶<✔£1 million in premium – saw a rate hike of 5.5% in÷₹ the fourth quarter, as did jumbo accounts, which™'±​ have more than $1 million in premium. Small ac♥♣counts – those with up to $25,000 in premi÷☆β um – were up 5%, while medium accounts – those ₽↓with $25,001 to $250,000 in premiu☆↔m – were up 4.5%.The “steady trend” of upwa±≠±rd rates reflects insurπ∑ε∞ers’ plans to continue increas≤♦ing prices across all lines exce‍​≈¥pt for workers compensatio $n, MarketScout said.Organizer:China Insuδεσrance Digital & AI Development 2020Web:httπ×‌εp://en.zenseegroup.com/p/560573/Contact:Ann λ✔"021-65650305

From :insurancejournalIt was a relat •δively quiet year for the Southeast in te<γrms of major catastrophes compared with 2018 w≥←  hen Hurricane’s Michael and Florence c≈₹×aused major damage in the region≤φ☆≥. This year, Hurπ"↔ricane Dorian sideswiped the Southeast coast&™γ$nbsp;and made landfall on the Outer B< anks of North Carolina but most of the area was≥π→Ω spared. Still, Aon said econom<£ic damage in the U.S. and Can∑♥★→ada was poised to approach a combined $1.5   ↑billion.Florida spent the year recoveri↕ ng from Hurricane Michael, which was upgra≠≈ded to a Category 5 storm by NOAA in April. Flo ÷rida officials have repea≤₩βtedly called on the i♦Ωnsurance industry to speed up theδ♠​ recovery process, with nearly ®£12% of claims still open aπ∑ ↔ year after the storm hit.Organizer:China Ins↕α"urance Digital & AI Development 2020¥©Web:http://en.zenseegroup.co×₩ m/p/560573/Contact:Ann 021• -65650305

From:businessinsuranceeinsurance renewa‍φ∞ls at Jan. 1, 2020, main£☆•ly saw single-digit increases,↓↔ with some exceptions, according to reports byσ✘™' reinsurance brokers released Thursday.Williπ"✘s Re, the reinsurance brokerage of Willis Tower<♣s Watson PLC, and Guy Carpenter & Co. LL∑∞C, a unit of Marsh & McLennan Cos. Inc. boδ¶∞th reported that year-end reinsurance re→σnewals varied by account and φ↕‍region, but the retrocessional reinsurλ±≠₽ance was under pressure.Rates on line for'σ  property catastrophe reinsurance programs remaiΩ≤₩ned stable and propertyλ∞ε" per risk pricing was dr‍ "×iven by individual program performance, the Willi  s report said.Although so↔​¶me Lloyd’s of London syndicates§σ≠∞ took firm positions on rate increases and the ∏> ®London market authorized capacitα"y decreased, that capact∑→&iy was replaced by new c£​apital and a strong supply from ←&δ♦other markets, Willis Re  δsaid.U.S. loss-free acβ‌≈counts renewed at flat to ↕•σ¥up 10% while those with losses saw i≤§ncreases of 10% to 50®↓%, the Willis Re report ∞λsaid, which was among the largest inδ€creases. Property catastrophe accounts without ">Ω•losses renewed at flat to up 5%,±±  while loss hit accou§÷©nts were up 10% to 20%, Willis Re saφ↕©✔id.According to the Guy Carpenter report,'←©∞ the brokerage’s global property ca§ γ✘tastrophe rate on line index rose 5% in 2019.Acc®λ≠₩ording to the Willis Re report, other laβ→☆>rge increases were seen in γ÷Central and Eastern Europe, "  where property progr ♥ams with losses saw increase✔™s of 5% to 20%, and Canada, where suc&$h accounts renewed up 10% to 40%.Mo→♦st other regions and countries saw propert×& y increases in the singl♠<e or low double digits, the reπ"port said.The Jan. 1 renewals saw some♦↔↑ “difficult” negotiations, according to a lett✘σ $er in the report from James Kent, global CEO§€☆β, Willis Re.The Guy Carpenter report said™÷≠  the reinsurance market was “asymmetrical,”>✘ adding “this is cer♠★tainly not a one-siz"♣e-fits-all market” and while overall capaci↓✘ty remained adequate, “alloca©♠ §ted capacity tightened no&δ&tably in stressed classes.”D​↕∏edicated reinsurance ca →pital rose 2% in 2019 and the year sawβ→ approximately $60 billion in global insured c‌δatastrophe losses, according to Guy Carp∑★enter, which was signi≈ ₹∞ficantly lower than 2017 and 2018.Alternative capΩ←✘ital, however, contracted b↑‍y approximately 7% percent “as investors w≠σ÷ere more cautious with new investments afte‍$r assessing market dynam'☆φics and pricing adequacy,” Guy Caπ ® rpenter said.The retrocession market “was c× ∏$hallenged … by trapped capital, a lac&®÷¥k of new capital and conti∑₹nued redemptions from thir®®"d-party capital providers,” a statem'★ent issued with the Guy Carpenter ε₽report said.However, significant retrocession'¶ providers returned to the marke♥☆‍t in the past two weeks, Wi ​llis Re said.Organizer:Chinaα™ Insurance Digital & AI Development 2020W‍'≥×eb:http://en.zenseegro¶ ∞£up.com/p/560573/Contact:Ann  σ021-65650305

Major information technology compani×☆™es in India are running the risk of termination λ‍&₹of their $1 billion contracts following Boe•≈€ing Co.’s decision to halt th♦¶‍e production of its 737 Max∞♦™ jets, MoneyControl reported citing the Busine★™¶ss Standard. Companies like T>£α↑ata Consultancy Services Ltd., Infosys™' Ltd., HCL Technologies Ltd., ∞♦≥≠Cyient Ltd. and L&<φT Technology Services Ltd. have<≥‌ outsourcing contracts w♠&"≥ith Boeing or its suppliers and Boeing’s jet cφ"risis is expected to affect these IT companiσλαes in the short run.From:businessinsurancΩ'eOrganizer:China Insurance Digital & AI Dev✔∞elopment 2020Web:http://en.zenseeσ"✘group.com/p/560573/Contact:A★☆≤"nn 021-65650305

France-based eyewear maker Essilor Internati♠α✔​onal S.A. has discovered fraudulent®" activities at one of its factories →<‌€in Thailand that could cause €190  ≠♦million ($213 million) in financial losses to¶★ the company, The Iris ♣"<h Times reported citing Reuters. The company±÷¶ has filed complaints in Thailand and ε∞≥∑has fired all the involve£♥✘<d employees. It hopes to re•♣πcover the losses from♠↓λ frozen bank accounts, insurance and lawsuit≈‍£"s.Organizer:China Ins₩ ∑§urance Digital & AI Development 2020W∏α♣±eb:http://en.zenseegroup.com/p/560573/Coπ☆ ntact:Ann 021-65650305

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