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- Boehringer Ingelheim £α'Partners with Inflammaso±∏$↑me Therapeutics to De→∏velop Novel Therapies for ≈↓Patients with Retinal Diseases
Boehringer Ingelheim and Inf♠₹∞lammasome Therapeutics Inc. (Inflammasome←δ) today announced they have entered into a co-dev ≥↓elopment and license ag $ reement to develop up to♣∏ three therapies for patients with re ♥₹tinal diseases. By combining Inf↑÷→lammasome’s unique intravitreal (Iφ∞VT) drug delivery technologi✔★es with Boehringer Ingelheim’s compounds from ≈>♣its retinal disease pipeline portfolio, λλ₩ Boehringer Ingelheim aims to develop novel thera≈$φ£pies for retinal diseases.
In 2019 there were an estimate★ £d 82 million patients'≤ in the seven key countries (U.S., Japan, Germ™€ £any, U.K., Spain, Italy, France∞α) affected by one of the three majo∏→r forms of retinal dis≈π♥ease: Age related macular degeneration (AMD) ≥, diabetic retinopathy (DR), and diabetic mac&↕ular edema (DME). Globally, ♥€the prevalence rates of these and othe≤★÷r retinal diseases are ∑§☆expected to increase over the next 10 year>πα$s primarily due to aging populations♥∞ and the global diabetes epidemic. Despite t↕herapeutic advances in some disease area s during the past years, the real world ♠∑results are poor, and there ar←'β←e no or only limited treatme σ★ nt options in many areas, resul>₽αting in an overall high•± unmet need. The collaboration betwδ een Boehringer Ingelhe×€≠σim and Inflammasome aims to address this cha↕✘llenge by using Inflammφ←asome’s technology to deliver therapeuti∑λ>cs in a biodegradable gel for ε≥≥mulation into the ey™φ₽φe.
“We are delighted to enter into a c±±★ollaboration with a company of₽§ Boehringer Ingelheim’s stature,” said Paul $÷Ashton, Chief Executive Offi≠δ♣cer of Inflammasome Therap ★•↑eutics. “We look forward to working wit♠π'®h their team to leverage our respective techn₹$ologies and expertise ↓to develop new therapies for devastating retina→¶©"l diseases leading to blindness. ∞This collaboration fits our ✔•✔strategy of advancing the company via b€πδoth collaborations and €<internal development.”
“Boehringer Ingelheim is looking forward©♥ to developing Inflammasome’s n≈ovel technology for the deli∑δvery of our first-in- γ↕class retinal disease compoγ♥₹unds working jointly with Inflammasome’s γ÷≈∞highly experienced scientific team,§™” said Clive R. Wood, PhD, Sen♣§ior Corporate Vice Pr∏✔←'esident, Discovery Research at Boehringer Ing ∞elheim. “This will enable us t&≥♦o develop a broad range of nove£↓εl therapy options for the many patients with retiεσ←nal diseases waiting urgently for better and newπλ therapy options.”
Boehringer Ingelheim taΩ₩₽εkes a holistic approach in the developm≠ ♠•ent of novel retinal disease therapies, targεφ§eting key mechanisms in the pathogenesis of retin←&≠al diseases. The company has built a comprehen®λπ sive pipeline portfolio of nδ∏ext generation therapy approδ±←♦aches in various stages of development up to Ph₩¶≥"ase 2 in macular degeneration, diabet₩≤δσic retinal diseases and bey•₽ond. Inflammasome’s novel delivery tec♥∑$hnology using a long-acting degradable IVT implan→ t complements this portfolio.
Inflammasome is entitled to receive&₽≥ up to $160 million in up-front, research and dev✘→€βelopment support and milestone gated develop§₹ment payments as well as tie≠ε↕red royalties based on future co ÷>mmercial sales of developed products andΩλ♥$ other milestones due on commercialization.
information source:pharma focus Asia
2019 Asia-pacific pharma ε♠IP Leader Summit: http://en.zenseegroup.com/p/5>σ¥₽10934/will be held in Beijing on November 14-15, and will attract more≈± than 500 industry expe♦÷rts from domestic and foreign≤↓ pharmaceutical companies, ¥λπ↓biotechnology companies, governments, assoλ♣$ciations, law firms, intell♠£¶<ectual property agents and other cλ♦ompanies to attend.
Official registration and consultation channels:"∑
Contact：Ann
Phone: 021-65650305
From :businessinsuranceU.S. commercial±★ property/casualty rates rose 5% on averag→≈e in the fourth quarter of 2019, up £♠from 4% in the third quarter, re flecting insurers’ intent to conti•δnue to increase prices across most lines, online™₹β> insurance exchange MarketScout Corp ♥✘σ. said Monday.“Auto rate increases have been up∞≈ all year long; however ¶" ✔D&O (directors & o≥×♠fficers) and professiona♥γl rate increases have sp₩÷"iked significantly in the fourth quart★×δδer,” Richard Kerr, CEO of MarketScout¥∞ Corp. said in a staαβtement.Insurers are care♦®≤©fully analyzing their property exposureΩ©₹s using catastrophe modeling tools, he δ said. “We expect many of the mΩ≈✔ajor property catastrophβ≠e insurers to curtail their 2020 writings in Cal♦×ifornia brush and East and Gulf Coast wind ar×σ&eas. Naturally, this wil✔₹l result in higher rates to insu™↓¥₹reds,” Mr. Kerr said.D&a♦←¶mp;O liability rates increased by Ω8.25%, while commercπ>λial auto increased 8% in the quarter, anΩσ ☆d professional liability ∏" rates were up 6%, and umbrella/excess '♦<rates were up 5.5%, accor☆€☆ding to MarketScout.Commercial property rates inσ♣←creased 5.25% in the quarteπ®✘r, and business interruption rates ∏γ§were up 5%, while all other lines showed sma÷♦ller increases, except for workers compensation, &®σεwhere rates fell 1%, Mar♦α☆✘ketScout said.By industry class, transporβ>Ωtation and habitational saw the highest∞∏§α average rate increases at 9% and 8.✔¥Ωδ25% respectively, MarketScout ÷¥said.Large accounts – those with $250,001 to $1 ₽αmillion in premium – saw®δσ₩ a rate hike of 5.5% in the fourth quarter, as d™β<id jumbo accounts, which have more than $1 mi♥÷llion in premium. Small accounts – those wi₩→th up to $25,000 in premium – were up★λ& 5%, while medium accounts – t₽£★hose with $25,001 to $250,000 in pr€απ∑emium – were up 4.5%.The “steady trend” of γγ★αupward rates reflects in&≤surers’ plans to continue incre↕✘∑∏asing prices across all¶☆ lines except for workers com∏> pensation, MarketScout said.Organizer：China≤♣★ Insurance Digital & AI Development↓↑ 2020Web:http://en.zenseegroup.com/p/560573/Co↔δntact:Ann 021-65650305
From :insurancejournalIt was a relatively quiet ≥✘ year for the Southea↕±st in terms of major catastrophes compare€π>→d with 2018 when Hurric≠ ane’s Michael and Florence caused major damage ∞÷✘¶in the region. This year, Hurricane Dori✔'±÷an sideswiped the Southeast c← αoast and made landfall on the Outer B♣→÷•anks of North Carolina €±↓♣but most of the area wδ ₽as spared. Still, Aonγ↑ said economic damage in the U.S. and Can→ada was poised ↑Ωto approach a combined $1.★££≥5 billion.Florida spent the year recov≥±≤ering from Hurricane Michael, which&•πλ nbsp;was upgraded to a Category 5 storm '"by NOAA in April. Florida offic♥®ials have repeatedly&¥•∑nbsp;called on the insuα∏×®rance industry to speed u₹β→p the recovery process, with nearly 12% of claimε ©s still open a year after the storm hit.Organizer÷≈：China Insurance Digital & A<∑I Development 2020Web:http://en.zenseegroupφ♠$.com/p/560573/Contact:Ann 021-65650305
From:businessinsuranceeinsurance renewals at γαJan. 1, 2020, mainly saw single-digit≠ש increases, with some exceptions, accordiδ&ng to reports by rein✔↕surance brokers released↕§ε↑ Thursday.Willis Re, the rei"nsurance brokerage of Willis Towers Watso↕α÷n PLC, and Guy Carpenter & Cφ≈o. LLC, a unit of Marsh & McLennan Cos.α<≥® Inc. both reported that year-end reinsur→•ance renewals varied by acc↕₩ount and region, but the retrocession≤®α₹al reinsurance was und¥× er pressure.Rates on line for property cat₽>astrophe reinsurance programs remained staε σble and property per ri÷δ§<sk pricing was driven ↔'&by individual program performance, the Will♣©is report said.Although some Lloyd’s of London≥÷₩ syndicates took firm position λεs on rate increases >Ωand the London market authorized capacity dec"Ωreased, that capactiy was replaced by new caε♥↕pital and a strong supply frε±om other markets, Willis Re said.§$§σU.S. loss-free accounγ±ts renewed at flat to up 10% while those w ♣ith losses saw increases of 10λ≈% to 50%, the Willis Re report said, which w∞βas among the largest incr∞¶eases. Property catastrophe a¶Ω∏ccounts without losses renewed at flat to up"✔♥ 5%, while loss hit accounts were up 10% to 20%λ , Willis Re said.According to≥←™ the Guy Carpenter report, the brokerage’s g↔≤<lobal property catastrophe rate on line index ro✔βse 5% in 2019.According to the Will>←↓is Re report, other large increases were ∑∑•seen in Central and Eastern Europe, where prope→§rty programs with losses saw increases of 5%λ×¥ to 20%, and Canada, where such™↕₽£ accounts renewed up 10% to 40%.Most othe↓σr regions and countries saw property i♣→ncreases in the single or low double☆$₹ digits, the report saδ✔¥↕id.The Jan. 1 renewals saw some “difficult$≤” negotiations, according to a letter in •∑≤the report from James Kent, g¥£•lobal CEO, Willis Re☆γ.The Guy Carpenter report said the r±♦δeinsurance market was “asymmetrical,” addin₽£∞g “this is certainly not a one-size-fitλ&↕•s-all market” and while overall♣₩× capacity remained adequate, “allocated cε<apacity tightened notably in stresse''d classes.”Dedicated reinsurance cap™π>$ital rose 2% in 2019 and γσ™the year saw approximately $60 billion in ♥↔global insured catastrophe losses, according t£≈®o Guy Carpenter, which was significant♥¥©ly lower than 2017 and 2018.Alternative capital,α♦ however, contracted by approximately 7% p¶€ercent “as investors were moσδ♥♣re cautious with new investmentφ☆™s after assessing market dynamics and pr÷→✔icing adequacy,” Guy Carpenter sa↑♥id.The retrocession market “was cΩλhallenged … by trapped capital, a lack of≠ new capital and continued redemption≠♥±☆s from third-party capital providers,” a statemen§←₩™t issued with the Guy C↑φ'₩arpenter report said.However, sig©™nificant retrocession p£σ♦roviders returned to the market in the past two ✔'≈weeks, Willis Re said.Organ↓∑izer：China Insurance Digital &βΩπ≤ AI Development 2020Web:http://en.zenseegroup£<α$.com/p/560573/Contact:Ann 021-65650305
Major information tech♦✘nology companies in India≥> are running the risk of termination oβ εf their $1 billion contr"€₩±acts following Boeing Co.’s d≤§ecision to halt the production of its ♣ €737 Max jets, MoneyCont Ω•rol reported citing the Business S✔∞≥tandard. Companies like Tata •↑ Consultancy Services Ltd., Infosys Ltd., HC•ε↕'L Technologies Ltd., >±Cyient Ltd. and L&T Technology S£♠★£ervices Ltd. have outsourcing≥α≤☆ contracts with Boeing or its suppliers and Boe₹∏×Ωing’s jet crisis is expected to affect these I≥€T companies in the short run.From:businessinsura™€λ×nceOrganizer：China Insurance Digital &aε☆mp; AI Development 2020Web↑∞®:http://en.zenseegroup.com/p/560573/Contact:Ann¶♣δ 021-65650305
France-based eyewear maker Essilor International ♥₹σS.A. has discovered fraudulent activi✔©≈ties at one of its factories in Thailand that co↕≈€uld cause €190 million ($213 million) in fina≤ βncial losses to the com↓≠✔ pany, The Irish Times reporte"≥₽d citing Reuters. The company has fil ≤₩ed complaints in Thailand and has fir®"∏'ed all the involved employees. It hopes∞≥ to recover the losses fro✘∞↑m frozen bank accounts↕✘®∏, insurance and lawsuits.Organizer→ &：China Insurance Digital & AI Developmen©£'t 2020Web:http://en.zenseegroup.c☆β₽om/p/560573/Contact:Ann &™021-65650305
