Clene Nanomedicine, Inc., a clinic©₽α✔al-stage biopharmaceutical cα$>ompany, announced today± that the Sean M. Healey &∏∏× AMG Center for ALS at Mass General has s♠₩elected CNM-Au8 for inclusion in the first eve☆← r Platform Trial for the treatment of amyotδ¥<rophic lateral sclerosis (A∏×∞LS).
The Healey Center issued a call earlier this yea• r for the best therapeutic ca∑ndidates to apply for entry into the HEALEY ALS ★ Platform Trial. They received ÷♣↕∞responses from nearly 30 applicants across ten ↔≤≥countries. Members from the Healey Cπ₩>enter Science Advisory Committee, a group™< of renowned ALS scientists, cho✔δ ∞se the top five therapeutic candidates, i$©ncluding Clene's lead clinical asset, CNM-Au8₩₩. The selection of CNM-Au8 into the ♠>Healey ALS Platform Trial includes s£α→ubstantial financial support and provid♠¶es access to over 50 expert>λ ALS clinical trial sites•∏ ≠ across the United States.
"Our goal," said Merit Cu¥♣₽dkowicz, MD, MSc, Director of the Healey♣₩ Center, "is to lower the barriers for our phλ<∑₽arma and academic col®leagues to bring their exciting ther± 'apies for ALS forward t""o clinical trials. We are determin♥'ed to accelerate therapy developm£>ent for ALS."
Important preclinical work supporting the ♣€effort with CNM-Au8 was performed in the laborato$≈₽<ry of Nicholas J. Maragaki✔™€'s, Director of the ALS Center for Cell Therapy γ£and Regeneration Research at Johns Hopkins, u→ ≠sing human induced plurip↔€♥ otent stem cells from ALS pati$"ents. Dr. Maragakis is C→∞hair of Clene's Scientific Advisory Board for ↕<ΩALS.
Dr. Jonathan Glass, Professor of Neur↑♦ology and Pathology at Emory Univers→↕δity School of Medicine, as well as Director of€'≈β the Emory ALS Center, remarked, ©>&₽"CNM-Au8 is quite an interesting compound tha☆↔εt is ready for testing inα•£ ALS clinical trials. Its inclusion in the✘' ↔ Platform Trial initiative is an excellent ∏↕way to move forward for the develσ•opment of CNM-Au8 as a ±δ∏♥potential therapeutic for ALS."
"We are very pleased Clene's CNM-Au8 has been£'Ω selected for participation in the Healey ALS >αPlatform Trial. We believe the un©←↑ique mechanism of CNM-Au8 $αrepresents a promising new approa∞£>©ch for the treatment of neurodegene₹"♠rative diseases, including ALS, with ♠®™the potential for meaningful impact for the←☆÷§ community of people diagnosed witγεh this devastating and debi≤ litating disease," said Ro₩b Etherington, Presiden☆$t and CEO of Clene. "We are continuing the develo "™pment of CNM-Au8 in sev'↑eral clinical studies set to launch later this yeφ¥∞ar."
2019 Asia-pacific pharma IP $ Leader Summit: http://en.zenseegroup.com/p/±§•φ510934/will be held in Beijing on November 14-15, and will attract more than 500 industry exper∞←∑ts from domestic and fo§→↕reign pharmaceutical companies, biotech<¥nology companies, governments, associations, l✘<aw firms, intellectual ✘>¶property agents and other companies to attend.
Official registrationδσ♣ and consultation chan∞♥nels:
Contact:Ann
Phone: 021-65650305
From :businessinsuranceU.S. commercial propλπ φerty/casualty rates rose 5% on average ↑≠in the fourth quarter of 2019, up from 4% in t¥"he third quarter, reflecting insure€rs’ intent to continu' e to increase prices across most lines, on₹✘✘§line insurance exchange MarketScout Corp. said Mσ←✔onday.“Auto rate increases have been up all year ★'long; however D&O (directors & ∞officers) and professional rate i'λncreases have spiked sig•¶ >nificantly in the fourtδ<✘h quarter,” Richard Kerr, CEO of MarketScout γ§↕≥Corp. said in a state÷π≥ment.Insurers are carefully analyzing their p ₩™roperty exposures using catastrophe modelin↓$→$g tools, he said. “We eλλ∏xpect many of the major property catγ &astrophe insurers to curtai∏™→<l their 2020 writings in Califo←♥→<rnia brush and East and Gulf Coast wind arφ★$∑eas. Naturally, this wi≤φ♦ll result in higher rates to insureds,” Mr. Keδ≠<βrr said.D&O liabil↑±ity rates increased by 8.25%, while commercial a≥↔¥→uto increased 8% in the quarter, and professionβ™§al liability rates weγ↓×¶re up 6%, and umbrella/γβΩexcess rates were up 5.5%, according βto MarketScout.Commercial property rates increa✘★₹sed 5.25% in the quarter, and§£ business interruption rates were up 5%≠π, while all other lines showedαΩ→Ω smaller increases, except for workers compensa£☆ tion, where rates fell 1% φ♠₽, MarketScout said.By industry class, ♦ φtransportation and habitat✔γπ←ional saw the highest averag♠↑↔₹e rate increases at 9% and 8.25% respectively, γ↓MarketScout said.Large accounts – those with $•€→250,001 to $1 million in premium – saw a rate hik →e of 5.5% in the fourth quarter, as did jum₽ bo accounts, which have more than $1 mπ®illion in premium. Small accounts – those with up<γ® to $25,000 in premium '÷– were up 5%, while medium accounts – those with ≈$$$25,001 to $250,000 in premium – were upεγ 4.5%.The “steady tr★ δend” of upward rates reflects insurers’♦ plans to continue increasing prices across al€≤Ωl lines except for workers c↕β★δompensation, MarketScout s§aid.Organizer:China β$≠Insurance Digital & AI Development×✔ 2020Web:http://en.zens δ eegroup.com/p/560573/C™φontact:Ann 021-65650305
From :insurancejournalIt was a relatively quiet yΩ♥λear for the Southeast in terms of major cat' astrophes compared with 2018 when Hurricane’s Mi≤↕↓®chael and Florence caused major dΩ' amage in the region. This year,&nφδ©bsp;Hurricane Dorian sides ¥wiped the Southeast coast and® made landfall on the Outer Banks of N←✘€ orth Carolina but most of the area w♦<® as spared. Still, Aon said econom≥εic damage in the U.S. andε♠• Canada was poised to approach & a combined $1.5 billion.Florida spent the←σ✘ year recovering from Hurricane Michael, w≈₩"♣hich was upgraded to a Categor"↑∞y 5 storm by NOAA in April. Florida₽γ≥ officials have repeatedly ca≤÷lled on the insurance in¥♠"dustry to speed up the recovery process↓↑↓, with nearly 12% of claims still open a year a® αfter the storm hit.Organiz∏er:China Insurance Digital & AI De§₩↔velopment 2020Web:http↕ ://en.zenseegroup.com/p/560573/Cont£βact:Ann 021-65650305
From:businessinsuranceeinsurance renewals at Ja±♦→↔n. 1, 2020, mainly saw single-≈σdigit increases, with some ☆ ∞ exceptions, according to♥<$ reports by reinsurance brokers released Thursda™φ≠y.Willis Re, the reinsurance br↓∞okerage of Willis Towers Watson PLC, and Gu¥y Carpenter & Co. LLC, a unit of Mar§λsh & McLennan Cos. Inc. both reported that ye≠λΩ♦ar-end reinsurance renewals varied by§¶ account and region, but the retrocessiona •<l reinsurance was under pres♣<Ωsure.Rates on line for property catastrophe♣Ω reinsurance programs remained stable and pro÷φperty per risk pricing was driven by in✔<&¶dividual program performance≥≥, the Willis report sai≥↕¥d.Although some Lloyd’s of €∏ London syndicates tooγβk firm positions on rate<σ increases and the London market authorized ♠∏≤capacity decreased, that capactiy was replδaced by new capital and a strong★σ supply from other markets, Willis Re saidΩ↑.U.S. loss-free accounts reneφβwed at flat to up 10% while t♣✘δhose with losses saw increases of 10% ¶✔to 50%, the Willis Re report said, which ×₩was among the largest increases. Property catas≤✔λtrophe accounts without ♠λlosses renewed at flat to up 5%, while loss↕ hit accounts were up 10% toΩ≤♥♠ 20%, Willis Re said.According to the Guy Carpent€er report, the brokerage’s global prop♦✘¶erty catastrophe rate oβ☆×₽n line index rose 5% in 2019.According to the¥δ≤ Willis Re report, other large increases were sε≤φ↔een in Central and Eastern£× Europe, where property progra ÷$∏ms with losses saw increases π✘of 5% to 20%, and Canada, where such account'¥ Ωs renewed up 10% to 40%.Most oth≤εer regions and countries saw prop $erty increases in the single or low double d♣±≠igits, the report said.The Jan. 1 rσ≥♥βenewals saw some “difficult” negotiations, accord§ing to a letter in the report froβ↓✘m James Kent, global CEO, Willis Re.The Guy Carpε€♥enter report said the reinsurance marke λ∑t was “asymmetrical,” add♦εing “this is certainly not a one-size-fits-alπ$δ•l market” and while overall capacity remained ade®↑ quate, “allocated capacity tightened notab'"ly in stressed classes.”Dedi£€£ cated reinsurance capital rose 2% in 201÷Ω←9 and the year saw approximately $♣↔60 billion in global insured catast©≈≤rophe losses, according to Guy Carpenter★α♥, which was significantly αβ✔lower than 2017 and 2018.Alternative capitβ$al, however, contracted by approximat♠↑∞¶ely 7% percent “as investors ÷§↕were more cautious with new investments after as±©≤sessing market dynamics and pricing adeqε∞∑¥uacy,” Guy Carpenter said.The retr₩♦<ocession market “was challenged … by trapped ca♥φ£€pital, a lack of new capital and continβλued redemptions from third-party § £☆capital providers,” a statement issued wit<λh the Guy Carpenter report ' said.However, significant retγ rocession providers returned t ∑o the market in the past←≈$ two weeks, Willis Re said.Orλ¥₹ganizer:China Insurance Digital & AI δ↑Development 2020Web:http://en.₽βzenseegroup.com/p/560573/Contact:Ann 0 π$21-65650305
Major information technology compa£♦nies in India are running the risk of termin±±α₽ation of their $1 bi ≠♥€llion contracts following Boeing Co.’s de≤π↑αcision to halt the production of its 737 Max j€""ets, MoneyControl reported citing the Bus€÷✔iness Standard. Companies like Tat &a Consultancy Services Ltd., In≤×♦fosys Ltd., HCL Technologies♠ ☆® Ltd., Cyient Ltd. an±$₹d L&T Technology ε$&↔Services Ltd. have outsourcing contracts wα✘£♠ith Boeing or its suppli ♥ers and Boeing’s jet crisis is expected to affec$'t these IT companies in the short run.From:bπ♠•usinessinsuranceOrganizer:China &☆®"Insurance Digital & ₩÷AI Development 2020Web:http://en.zenseeg♥εεroup.com/p/560573/Contact:An≥&"n 021-65650305
France-based eyewear maker ♥₹φEssilor International S.A. ↔λεhas discovered fraudulent activities at one&★ε of its factories in Thailan©≥$d that could cause €190 million ($2♠™★13 million) in financ©→ial losses to the company, The Irish Times rep¶§orted citing Reuters. The company has filed co$≥γmplaints in Thailand and has fired all the involv≈↑ed employees. It hopes to r₩≈ecover the losses from frozen bank accounts, insu∞★rance and lawsuits.Org&γ×anizer:China Insurance Digital & AI Dβ¥γevelopment 2020Web:http://en.zense§₽↑≠egroup.com/p/560573/Contact:Ann 021-65650305