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- IBio’s Collaboration with South A₹≤≈÷frica’s AzarGen Biotechnolog✘★≈ies Advances to Next Stag≥&÷e
iBio, Inc. today announced¥¶≈← that it has entered ¶ •into the initial Statement of Work (“<∑SOW1”) under its Memor$®andum of Understanding (“•↑≠↔MOU”) with AzarGen Biotechno✔₹logies (Pty.) Ltd. (“AzarGen”).
Following iBio’s successful use↔☆¶ of its technologies♠♣π and manufacturing capabilities to advance→™™φ the development of AzarGen’s surfactant protein φ£therapeutic through an initial assessment o₩σα↔f production feasibility, in May 2017, the t≠£wo companies expanded their ₩ ≥¥collaboration by initiating the develop←€£¶ment of a plant-made rituximab ₽↕✔for the South African market under tδ$he MOU.
Pursuant to the SOW1, iBio will manu∏λfacture research quant€™↓ities of a plant-made rituximab f☆♠∞or AzarGen using iBio’s proprietε•"ary FastPharming™ System. Followi♦↑£ng batch production, the drug product candid&πate will undergo testin>×♥g via iBio CDMO’s bioanalytical servic'∞≠es.
“After demonstrating the success of our p♠↕÷§latform through our opening proje₩∑₹ct with AzarGen, we a♠±÷re now advancing to the next stage of th≥Ω≤e two companies’ collaboration,” commente÷↔∏d Robert B. Kay, iBio’s Chairman and CEO. “Wα↑∏•e look forward to helping Aza♣₽rGen develop a plant-ba✔¥€βsed, bio-similar rituxima' ≥↓b product for the South AfricΩ<γan market.”
“The early success in comb≥ λ∞ining iBio’s and AzarGen's advanced geα♠netic engineering and synthetic biology γ¶techniques in plants really empowered us to evolv€δe our business plans and product prio≤πrities to initiate development of a ₩×>biosimilar version of rit'ε∞uximab,” said Dr. Mauritz Venter,"♦✔★ CEO of AzarGen. “As we β continue to move tow©Ωard the initiation of advanced pre↓-clinical activities, w∞φ₩e are confident that iBio CDMO π€≈×is ideally suited to provide us with¶§δ the requisite long-term process developmen&§t and cGMP manufacturing support×. We are excited to take this important ste≥≥p forward in advancing this program. Focusing on ≤ π↔accessibility and affo®↔←♣rdability of biologicalπ↔₩ medicine for the Afr®α↓ican continent, we look ≈•©∑forward to initiating additional proje₹cts with iBio as we progress.”
Rituximab was first approved by the U.S. Foo€σ≈>d and Drug Administration in 1997 for treatme±₽ nt of certain B cell non-Hodg÷•←₩kin lymphomas. Since that ti±₽me, its clinical uses have expanded to encomp♣•ass treatment of chronic lymphocytic leukemia, ∞"≥∑as well as a range of autoimmune diseases, in♥€€cluding certain types of rheumatoid a☆ >rthritis. Rituximab has been placed on the W♥≥orld Health Organization’s List of Essen★♣ λtial Medicines and it was ranked as one of t©₽'he world’s top-10 selling pharmaceuticals in ®"2018.
2019 Asia-pacific pharma IP Lea→≠¥≠der Summit: http://en.zenseegroup.com/p/40471σα6/ will be held in Beijing on November 14-15, and will attract more≠ ★ than 500 industry experts from domesγγ&¥tic and foreign pharmaceutical compa'αnies, biotechnology compani ♠×£es, governments, associations,¥ law firms, intellect₩©•↑ual property agents and other companies to attק×Ωend.
Official registration an≥§✔d consultation channels:
Contact：Ann
Phone: 021-65650305
From :businessinsuranceU.S. com•> mercial property/casualty rates rose 5% o&→≥•n average in the fourth quarter of 2019,βσσγ up from 4% in the thirdλ®↕ quarter, reflecting insure≥₹↔rs’ intent to continue to increase prices¶® across most lines, online insurance exchange M♠ arketScout Corp. said Monday.“Auto rate increas'₩↓es have been up all year β↔long; however D&O (directors >₹ & officers) and pr&∞↕ofessional rate increase≈Ω"¶s have spiked significantly in the ±★δfourth quarter,” Richard Kerr, CEO of M→☆©arketScout Corp. said☆≤ in a statement.Insurers are carefu™₩₽↔lly analyzing their pr♥☆★γoperty exposures using cata¶♠strophe modeling tools, he≈↔ said. “We expect many of the major propeδ↓rty catastrophe insurers to c±÷♦urtail their 2020 wr✔→itings in California bru♥₹×sh and East and Gulf Coast wind areas. ±∑×Naturally, this will result in higher rates to in☆∞∑εsureds,” Mr. Kerr said.D&Oβ↑π liability rates increased÷" by 8.25%, while commercial auto increased 8% in↑✘ the quarter, and professional liability rates w>™'ere up 6%, and umbrella/excess r∑εates were up 5.5%, according to MarketSc §φεout.Commercial property rates increased 5.25☆Ωα% in the quarter, and business interrup∏ tion rates were up 5%, while a₽♥☆ll other lines showed smaller iλ↕≤ncreases, except for workers coλ÷¶∏mpensation, where rates fell 1%, MarketScou>↓t said.By industry c₩ ↓↓lass, transportation ♠ λand habitational sawεβ♦ the highest average rate increases at ♦γ×9% and 8.25% respectively, Market₹&Scout said.Large accounts – those with↕®Ω $250,001 to $1 milli∏€↕on in premium – saw γ↓✔a rate hike of 5.5% in the fourth quarter, asβ¥♦ did jumbo accounts,¶₩§γ which have more than∏ "Ω $1 million in premium. Small accounts∏↕ – those with up to $25,000 in premium – werδ≠ e up 5%, while medium accounts – ♥÷those with $25,001 to $250,000 ¥✔←in premium – were up<<← 4.5%.The “steady trend” of upward rates ββ$reflects insurers’ plans to continγ≠♣✔ue increasing prices across all lines e"•<>xcept for workers compensation, MarketScout said.ε∑α Organizer：China Insurance Digital & AI Deve©β>♥lopment 2020Web:http://enσ←±.zenseegroup.com/p/560573/Contact:Ann 021-6565®↕0305
From :insurancejournalIt was a relative>ly quiet year for thλ♠ e Southeast in terms of major catastrophesδ≈ compared with 2018 w•hen Hurricane’s Mich£≥Ω ael and Florence caused major damage in the r¶¥egion. This year,&nbs±£p;Hurricane Dorian sideswiped thσ↔e Southeast coast and mad✔σ€e landfall on the Outer Banks of North Car ★olina but most of the area was spared. Still,&nb≥≥sp;Aon said economic damage in the U.S. ©↓↕↑and Canada was poi<•sed to approach a combined $1.5 billion.Flori×✘da spent the year rec£overing from Hurricane ₹↕Ω$Michael, which was u→←pgraded to a Category 5 storm✘↑π£ by NOAA in April. Florida officiaαβ∞ls have repeatedly called on the ins$ &urance industry to speed up the recoverφ•☆→y process, with nearly 12% of claims Ω¶still open a year afλ÷®&ter the storm hit.Organizer：China Insurance α♥≥Digital & AI Development 2020Web:ht∏♦∏tp://en.zenseegroup.com/p/560573/Contac♥<£t:Ann 021-65650305
From:businessinsuranceeinsurance renewalsδλ at Jan. 1, 2020, mainly saw single-dig↓∞ it increases, with some exceptions, ac★↑→cording to reports by reinsurance brokers releas® ed Thursday.Willis Re, the r☆<♠einsurance brokerage of Willis Towers™↑¶≠ Watson PLC, and Guy Carpenter & Co. LLC, a ↔> unit of Marsh & McLennan Cos. Inc. both repo δ&•rted that year-end reinsurance renewals varied ¥<<by account and regionδα, but the retrocessional reinsur≠≥δance was under pressure.Rates on line fo ★≤r property catastrophe reinsurance progra"$•ms remained stable and proper←↑ty per risk pricing was driven by individual prog£ ®↔ram performance, the Willis report☆∞πδ said.Although some Lloyd’s of London syndicat ≈♥es took firm positions on rate increases and the London market authorized capacφ≠ity decreased, that capactiy was ₹>Ωreplaced by new capital and a strong suppε®α×ly from other markets£✔, Willis Re said.U.S. loss-÷↓free accounts renewed φ<✔σat flat to up 10% while th©$€ose with losses saw increases of≥γ↓ 10% to 50%, the Willis"φ♥ Re report said, which was among the largest incrδγ±δeases. Property catastrophe acc<ounts without losses reγγ→newed at flat to up 5%, while l ↓§oss hit accounts were up 10% to 20%, Williλ↓s Re said.According to the Guy Carpβ→¶enter report, the brokerage’s gσ™λlobal property catast™₹rophe rate on line index rose 5% σin 2019.According to ±λthe Willis Re reportφ∏, other large increases were see↕ ≤n in Central and Eastern Europe, where property p©★rograms with losses saw increases of 5%Ω☆α to 20%, and Canada, where such acco♠∑™unts renewed up 10% to 40%.Most ♣☆¶ other regions and countries saw property δ÷↕increases in the single or low double digit♣♥™s, the report said.The Jan. 1 renewals saw som'πe “difficult” negotia¶≥•tions, according to a letter in →✔the report from James Ke÷βnt, global CEO, Willis Re γ$.The Guy Carpenter report said≤Ω the reinsurance market ♥✔♥was “asymmetrical,” adding “this is certaγ↔≠inly not a one-size-fits-all ₹<₽market” and while overall capacity remaine↑¥£∏d adequate, “allocated capacity"₹ tightened notably in stressed ₹∑★φclasses.”Dedicated reinsuran$¥ce capital rose 2% in 2019 and the y§§ear saw approximately $60 billion in global in±₩♦sured catastrophe losses, accord €∑ing to Guy Carpenter, which was signif•≈∑icantly lower than 2017 and 2018π✘∏♥.Alternative capital,δ↑ however, contracted"↔ by approximately 7% percent “as investors wer∏≠÷e more cautious with new investments after asse♦ ssing market dynamics and pricing adequ•∞"acy,” Guy Carpenter said.The retrocession market ®“was challenged … by trapped capital, a ☆λ≈ lack of new capital and continued re£↓¥demptions from third-party capi§≤×tal providers,” a statem™βent issued with the Guy Carpenter re±≤§port said.However, significant₽&• retrocession providers returned ☆≠€to the market in the past two weeks, Willi♠€s Re said.Organizer：China Insurance Digital &am∞✘¥p; AI Development 2020Web:http://en.zenseegrou✘>p.com/p/560573/ContacΩ ®t:Ann 021-65650305
Major information technology companies in India •πεare running the risk of terminaα tion of their $1 billion≥' contracts following Boeing Co.’s decis×₹₹₽ion to halt the production of≥ its 737 Max jets, MoneyContro πl reported citing the Business Standaλ' rd. Companies like Tata Consultancy Services☆φ Ltd., Infosys Ltd., HCL Technologies Ltd ., Cyient Ltd. and L&T Technology S☆ ™ervices Ltd. have outsourcing contracts wit↑≠×h Boeing or its suppliers and Boeing’s jet♣ε crisis is expected to affect these IT companies ☆ππ≥in the short run.From:businessinsuran₽©ceOrganizer：China Insurance Digital & AI☆α<γ Development 2020Web:htt ↓p://en.zenseegroup.com/p/560573/Contact :Ann 021-65650305
France-based eyewear maker Essilor International S.A. has discovered fraud±γ↑>ulent activities at one of i§$"ts factories in Thailand that could÷β←♥ cause €190 million ($213 million) in fina$$ncial losses to the company, The Irish∑α₽ Times reported citing Reuters. The₹™ company has filed complaints in Thaβ×®σiland and has fired all the involved empl∞←₹oyees. It hopes to recover the losses from fr☆•ozen bank accounts, insurance↑ and lawsuits.Organizer：China In≠★✘♠surance Digital & AI DeveΩ> lopment 2020Web:http://en.zenseegro™<γ£up.com/p/560573/Contact:Ann 021-65650305
