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- Gotham Therapeutics Eσ&stablishes Advanced Oncology Profi≥✘ling Cascade with ProQinase to Progress its P©ortfolio of Epitranscriptomic Dru¶ε€g Candidates
Gotham Therapeutics Establishe♣←♦↔s Advanced Oncology Profi₹∑∞↔ling Cascade with ProQinase to Progress its PortΩ≥φ&folio of Epitranscriptomic Drug ←÷∏☆Candidates
WEDNESDAY, OCTOBER 30, σε2019
Gotham Therapeutics, a biotechnology company deve♠≈λloping a novel drug class ta✔≥πλrgeting RNA-modifying proteins, and ProQinase,♠♦ an early stage drug-d↓↑α&iscovery company, recently acqu©✔ired by Malvern/PA-b✘≈ased Reaction Biology Corp., t≥← βoday announced that they have est∏∑♥÷ablished an array of advanced biochemiβ"cal and cellular assays to characterize¥& • epitranscriptomic-direc♣♥ted compounds.
“Establishing tailored target en♦♠✔↓gagement, cell biology, pheno✘✔¥typic, and in-vivo assays to evaluate compo↓&'unds originating from ≥δ×₹our three most advanced epitranscriptomic pr'↓✘ograms in parallel is a cruφ₩cial next step to develop our broad pi€<peline towards the clinic,” said Dr. Gerhard Müll→®σer, Chief Scientific Officer φ•¶of Gotham Therapeutics. “By pursuing the ful ©'l range of the reader-writer-era ♠>ser continuum, we are a✔ εble to focus on targe>≠ts with the most compelling links to dise•→>ase and advance those programs in ←β±tandem.”
“Combining our high proficiency in p€☆φroviding customized solutions as ear'εly stage drug-discovery services, including tailo&₩r-made biochemical and cell-based assays, with Go δ✘>tham’s expertise in epitransλ↕∏criptomics, we were able to establish β →in a very short time a set of customizβλ§≠ed enzymatic and cellular assays f♠£or compounds addressing thr¶ee different mRNA-modifying targets∞ε↑,” said Dr. Sebastian Demββpe, Chief Executive Officer of ProQinase£δ. “We look forward to supporting Gotham as the c πσompany advances its programs into ¶≠lead optimization and to c≈₩ontinued work with the Got≤π ham team assisting the company to a''dvance its broad pipeline in a time-effective<£ manner.”
In addition to establi↑λshing a tailor-made profiling cascade for ↓¶compounds from its three most ad↕®vanced programs, Gotham has al€≤so made progress in str>☆ ✔engthening its drug discovery engine and develo δping its candidate base. Gotham previou¥βsly completed the gene-to-lead phase for it's drug discovery project targetin≠ε✔g the METTL3/METTL14 complex and established a £₹robust discovery proc±Ω>ess as a platform for future projects. The♥ $ company has also generated a library of high-qua•β↕≤lity compounds tailor-made for accelerated ±σβhit generation and hit-to-lead eφ←xpansion against large parts of the epitra¥★nscriptomic target spacφ≠✘≥e. This library includes a collection of ov→≠&γer 2,000 analogues covering over 80 ¶Ωdistinct chemotypes that will be used to fu©$rther accelerate Gotham’s drug discovery ↔→♦efforts as it expands its pipeline.
2019 Asia-pacific pharma IP Leader Summit: http://en.zenseegroupσ.com/p/510934/will be held in Beijing on November 14-15, and will attract more than 500 industry ∏ experts from domestic∑< and foreign pharmaceutical companies, €λbiotechnology companies, governments, assδ >≠ociations, law firms, i>≤ntellectual property agents and oth¶λ✔er companies to attend.
Official registration and consultation∏φ± channels:
Contact：Ann
Phone: 021-65650305
Email：Marketing@zenseegroup.com
http://en.zenseegroup.com/p/510934
From :businessinsuranceU.S. ελ&commercial property/casualty rat<<es rose 5% on average in the fourth '₽←≤quarter of 2019, up from 4% in the third quarter,☆♠± reflecting insurers’ intent to£β continue to increase pricγ >es across most lines, ₹δαΩonline insurance exchange MarketScout Cor ←"p. said Monday.“Auto rate increases have been upβ all year long; however D&O (directors &×♣♣♣amp; officers) and professio↓★δnal rate increases have spiked sλ ignificantly in the fourth quarter,” Rε≠ichard Kerr, CEO of MarketScout Corp. s<φaid in a statement.Insurers are carefully an∏alyzing their property exposures using cat£₩≥↓astrophe modeling tools, he said.₹ ε “We expect many of the majoπ≤r property catastrophe insurers to curtail♠×↑∞ their 2020 writingsε•∞> in California brush and♦↑σ↔ East and Gulf Coast wind areasδ≈. Naturally, this will resu←₹π₽lt in higher rates to insureds,” Mr₽Ω←. Kerr said.D&O liabilit✔↕↑<y rates increased by 8.25%, while commerci← ♥←al auto increased 8% in the q₩∞♠uarter, and professional liability ratδ÷¥es were up 6%, and umbrella/excess rates >¶ ∏were up 5.5%, according to §•≥≠MarketScout.Commercial property rates increased 5§>¥π.25% in the quarter, ¶and business interruption rates were up 5%Ω∑✔, while all other lines showed smaller inφφ↑creases, except for worke←✔rs compensation, where rates fell 1%¥≤, MarketScout said.By industry class, transpλ¶₩ortation and habitational saw the highest av∏¥×↕erage rate increases at 9% and 8.25% respec±≤tively, MarketScout said.Large accounts – εβ↕those with $250,001 to $1 million in premium ∏↕↓– saw a rate hike of 5.5% in t§×≠he fourth quarter, as did j€δ×δumbo accounts, which have more tha<"εn $1 million in premium. Sma§¶>ll accounts – those with up to $25,0≈σ×ε00 in premium – were up 5%, whi↔₩φle medium accounts – t> ↓hose with $25,001 to $2 γ×$50,000 in premium – were up 4.5%.The “steady trenφδ↔d” of upward rates reflects insurers’ plans to >±≥continue increasing prices across allφ↓→> lines except for workers compensa↔'>tion, MarketScout said.Organizer：China Insuranc'♥σe Digital & AI Deve≥♣lopment 2020Web:http://en.zensee γγgroup.com/p/560573/Contact:Ann 021-6&βγ5650305
From :insurancejournalIt was a relatively quiet yσα ear for the Southeast in terms of major cat♣φastrophes compared with 2018 when Hurricane’s λΩπ₩Michael and Florence caused major d™♦∞amage in the region. T"±≠σhis year, Hurricane Dorian sideswiped the S↕≤Ω•outheast coast and made landfall on ™↑αthe Outer Banks of North Caφ&rolina but most of the area was spared. Sti↕Ω ✔ll, Aon said economic damage in the U.S. anΩ☆₽★d Canada was poised to approach a co'×mbined $1.5 billion.Florida spe£φnt the year recovering from €<Hurricane Michael, which was upg₽↔raded to a Category 5 storm by NOAA in Apr ☆¶∞il. Florida officials have re₹∑peatedly called on the& φ← insurance industry to speed up <™the recovery process,$> with nearly 12% of claims still open a year β≤after the storm hit.Organizer：China •×Insurance Digital & AI Development 2020Web:ht↕≈tp://en.zenseegroup.com/p/560573/Contact:A&>nn 021-65650305
From:businessinsuranceeinsurance rene>wals at Jan. 1, 2020, mainly saw singl≠•'e-digit increases, with λ÷αsome exceptions, accorγ λding to reports by reinsurance brokers released≤✔®& Thursday.Willis Re, th©₽•e reinsurance brokerage of Willis Towersφ' Watson PLC, and Guy Carpenter & Co. LLC, a §↑unit of Marsh & McLennan Cos≤±∏. Inc. both reported that yea∏₹r-end reinsurance renewals varied b☆©π↓y account and region, but the retrocessionalσ¶ → reinsurance was under pressure.R'↓♦¶ates on line for property catastrophe rei→£♣nsurance programs remained staσ ble and property per risk prici☆≥★ng was driven by individual prog♥ ≠'ram performance, the Willis report said.Altho&₽™ugh some Lloyd’s of London syndicates took firm p&♥∑±ositions on rate increases and the London m•≈♠arket authorized capacity decreased, that ★←capactiy was replaced by new capital and a strong±±•✘ supply from other markets, Willis Re αsaid.U.S. loss-free ¶★$accounts renewed at flat to up 10% whi ♦le those with losses saw increaΩ↓ses of 10% to 50%, the Willis Re report said, wh¥£₩≠ich was among the largest increases. Property cat$✘©✔astrophe accounts without losses renewed at flat €to up 5%, while loss hit accounts were u∞∏↑p 10% to 20%, Willis Re said.According t•€≥☆o the Guy Carpenter report, the brokerage’s glo★™bal property catastrophe rate on line index≠∞ rose 5% in 2019.According to the Willis Re reβ ≥port, other large increases were seen in Cen€<♦tral and Eastern Eurα←ope, where property pr"↔≠ograms with losses saw inc÷★reases of 5% to 20%, and Canada•γ ™, where such accounts renewed up 10% to 40'λ©≥%.Most other regions and count£Ωries saw property increases in th∞★e single or low double digits, the ≥↕©report said.The Jan. 1 renewals λ↓∑saw some “difficult” negotia∏↑tions, according to a letter in the repo★ rt from James Kent, global CE★•"O, Willis Re.The Guy Carpenter report saidασ the reinsurance mark✔★♦et was “asymmetrical,” ∞ adding “this is certainly not a one€π-size-fits-all market” and w≥hile overall capacityλ δα remained adequate, “allocated ∑αcapacity tightened notably in stressed÷♠ε classes.”Dedicated reinsurance capital rγose 2% in 2019 and the year saw approxim&±ately $60 billion in g↑✔★lobal insured catastrophe losses, acε↑cording to Guy Carpenter, which was signifi₩★←cantly lower than 2017 and 2018.Alternat←±±ive capital, however, contracted by δ∑approximately 7% percent “aγ∞Ωs investors were more cautious with new invesε★£®tments after assessing marke≈₽t dynamics and pricinφφ↕g adequacy,” Guy Carpenter sσ÷÷aid.The retrocession market “was chalδ✔lenged … by trapped capital, a lack o<β'→f new capital and continued γ★λΩredemptions from third-party capital providers,∞≈♦” a statement issued with the Guy Carp ₩&αenter report said.However, ✘significant retrocession providers returned© to the market in the past two weeks, ★€Willis Re said.Organizer：China Ins∑&urance Digital & AI Development 2020Web:ht ↔tp://en.zenseegroup.com/p/560573/Contact:Ann 02σ£1-65650305
Major information technology companieε↓s in India are running the risk of terminat≠≥↓↓ion of their $1 billion &¶"₩contracts following Boeing Co.’s'"¶ decision to halt the producti ☆&on of its 737 Max jets, MoneyContro→l reported citing the Business ±δStandard. Companies like Tata •↑α Consultancy Service✘§s Ltd., Infosys Ltd., HCL Tech ∑>₹nologies Ltd., Cyient Lt ₩d. and L&T Technology Services Lt✔α♣d. have outsourcing contra£εcts with Boeing or its₩δ' suppliers and Boeing’s jet crisis ✘±÷is expected to affect these I$®∑T companies in the short runγ∏.From:businessinsuranceOrganizer：China Insuranc®™e Digital & AI Development 2020Wγ≤¥≠eb:http://en.zenseegroup.com/p/560573/Co♦☆®ntact:Ann 021-65650305€×≠≥
France-based eyewear maker Essilor Internationa$l S.A. has discovered fraudulent÷×÷ activities at one of its factories ×ΩΩ¥in Thailand that could cause €190 million ($213 m₽εillion) in financial losses to the company, The I∑ <rish Times reported citing Reuters. The com✔>☆pany has filed complaints in Thailand and has fi↓red all the involved employees. It hopes to recov >'er the losses from f∞÷rozen bank accounts, insurance and la€÷wsuits.Organizer：China Insurance Digi∑♠tal & AI Development 2020Web:http://en.ze✔∞nseegroup.com/p/560573/Contact≤:Ann 021-65650305
