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HistoIndex Announces Glo★↕↑bal Partnerships To Expand AI-Based Di€×$™gital Pathology Platform
MONDAY, OCTOBER 28, 2019
HistoIndex announces the expansio©↓n of its AI-based digita☆≈l pathology platform toward£σs large-scale NASH preclinical programs₩ ✘α for pharmaceutical and biotech companies to£☆ achieve quantifiable and repr☆₩←™oducible data on therapeutic ≥≈×responses in NASH ani♥<mal models, and to aid CROs as well as researchγ ✘ agencies in validating new€π♦ models mimicking the NASH disease.
Published preclinical studies have demonstrated₽₽ the use of HistoIndex's fully©γ quantifiable Second Harmonic Generation (SHG) ↕$technology as a highly accuratλγΩ₹e stain-free method that can monitor t± ♥he efficacy of various t"÷herapeutic agents, by quantifying more t±®₽↓han 450 NASH-associated pa§®rameters in fibrosis, i♠&nflammation, ballooning and↔✔ steatosis. The information of t♣≠✘÷hese NASH-associated parameters €≈>gathered from the entire liver ti€ssue, provides comprehensive insights o&≠™n the mechanism of action of¶Ω↑ the therapeutic agent. As a drug disc$↔←•overy tool, HistoIndex↔'s SHG-enabled digital pa Ω♣thology platform will allow pharmaceutic$αal and biotech companφΩγies to select promising lead can↓≥didates for further optimization and α®φ make informed decisions in the managementαγ of their NASH drug developme§♦→™nt pipeline.
In addition to ongoing NASH cli≤±nical trials, HistoIndex is÷σ☆ currently involved in multiple preclinical∏£ ♣ studies, most of which are cond↕★≈₹ucted by major pharmaceutical ∏€and biotech companies, medical univer"∑Ωsities, CROs and research a•&'gencies. Notably, Histo£₩Index has recently entered ☆×into a collaboration with the A*STAR's Genome¥∞£ Institute of Singapore (GIS) to val$α↑idate their in vivo and in vitro NASH mode∞ls based on Asian-centric clinical data. Saysε©δ¥ Professor Patrick Tan, Executive Director of th♥ •e Genome Institute of Singapore (GIS), "At GIS↓€, we conduct our preclinical studie©±s on fatty liver involvi'♥<ng data from animal ≥≥models based on patient-derived transcriptomic d♣≥φata. This has a high transl↑§∞ational potential as it helps us to p ≥¶inpoint new therapeutic targetsα♦ and their validation. Th↓→₽erefore, using a fully quantitative, reliable a♠γ' nd objective pathologica©&εl evaluation such as Histo×₩✔Index's AI-based digital pathology platform is∞φ essential to the success of our effor≥σts in therapeutic target discovery."
HistoIndex is also a partner with g≠∞lobally-renowned CRO, WuXi Appε€™tec, in advancing their NASH preclinical program≤★'s with advanced R&D and s™®≤mart imaging analysis capabilit¶πies. Published study data wil€l be available for discλγ ®ussions during network♥↓φing opportunities throughout AASLD's The L♦✔ iver Meeting® in November 2019.
"We are very excited to extend our AI-based SHG♥> platform to preclinical studies><± to help companies with drug discoו×very programs select↔∞ promising lead candidates for ₩ further optimization and subsequent clinica€εl development," says Dr Poon T₩hong Yuen, Chief Executive Officer of HistoIndex₹γ. "Our SHG image analysis plat✔£form has already been used t ↔∏ o analyze the efficacy of a series ₩γ®of promising drug candidates ✔€for NASH within various animal models co§∞★↑mmonly-used by the industr☆> ₩y, and we believe these pα↔®πreclinical partnerships w≈>ill help drive the adoption of our platfoπrm significantly."
information source:pharma focus Asia
The original link:https:https://www.pharmafocusas♥"ia.com/news/histoindex-announces-global-partnersε ↔♣hips-to-expand-ai-based-digital-pathology&-platform
2019 Asia-pacific pharma IP Le¥↔↕"ader Summit: http://en.zenseegroup.com/p/510934/σσwill be held in Beijing on November 14-15, and will attract more¥"♠ than 500 industry experts from domestic and for€ eign pharmaceutical co÷±φ÷mpanies, biotechnoloδ©✘gy companies, governments, assoc→ ∑iations, law firms, intellectual property agents φ ™and other companies to₹Ω attend.
Official registration and consultation ch€↔®≈annels:
Contact：Ann
Phone: 021-65650305
From :businessinsuranceU.S. comβ₩mercial property/casua¥±≤lty rates rose 5% on average in the four≈λ÷th quarter of 2019, up from 4% in the thir☆¥d quarter, reflecting insurers’ intent t≤∞≤ o continue to increase prices across moπ>st lines, online insurance exchange MarketScouλ₽δt Corp. said Monday.“Au§>to rate increases have been up all y±©ear long; however D&O (directors →☆& & officers) and professional rate in>←Ωcreases have spiked significantly in the fourth q♠φδ≤uarter,” Richard Kerr, CEO of MarketScoutλ∞♦ Corp. said in a statement.Insurers are carefuδ↔lly analyzing their property exp ₹™osures using catastrophe mo♥↓$deling tools, he said. “We expect man'₽φy of the major property catastrophe insurers to₽☆• curtail their 2020 writings inπ₽↓ California brush and East and Gulf Coast w★$וind areas. Naturally, this wil>φl result in higher rates tγ ♣•o insureds,” Mr. Kerr said.D&♦∞α✔;O liability rates increased by 8.25%, wh♣δile commercial auto increased 8% in the quar ↔ter, and professional liability rates←σ♦γ were up 6%, and umb∑☆rella/excess rates were up 5.5%, according &α to MarketScout.Commercial property rates <♣→ increased 5.25% in the quarter, and busines♠☆σs interruption rates were up 5€φ'φ%, while all other lines&§₹ showed smaller increases, except for workers com±ε₽pensation, where rates fell 1%, Market≈β₹γScout said.By industry class, transportation andδφ habitational saw the highest average rβ★↓×ate increases at 9% and 8.2α≥5% respectively, MarketScout said.Large accou ≥nts – those with $250,001 to $∑≥1 million in premium – saw a rate hike of 5.5 &±% in the fourth quarter, as did jumb→↑ o accounts, which have more than $1 →™✘•million in premium. Small accounts ≥λ – those with up to $25,000 i≥ n premium – were up 5%, while medium accounts – $≤≥εthose with $25,001 to↕ £ $250,000 in premium – were up 4.5%.T≠•×he “steady trend” of&∞φ☆ upward rates reflects insurers’ plans to>" continue increasing prices across all lines e>δ≥ xcept for workers compensation, MarketSco÷↓§®ut said.Organizer：China≠ ☆ Insurance Digital & AI Development 2020Web:∏σ♦http://en.zenseegroup.δ≈com/p/560573/Contact:Ann ₹<¶§021-65650305
From :insurancejournalIt was a relatively'←& quiet year for the Southeast in terms of m× ✘ajor catastrophes compared with 2018 when Hurri♦>>γcane’s Michael and Florence cau≠♦→sed major damage in the region. This ye₩↓♦ar, Hurricane Dorian siβ♣♥deswiped the Southeast coast anφλ←★d made landfall on the Outer Banks of North₹≤ Carolina but most of<¶ the area was spared. Still, Aon ←©™÷said economic damage in the U.S. and€ Canada was poise↕♠d to approach a comb βined $1.5 billion.Florida spent the year recove ¶ring from Hurricane Michael, whic←±®≠h was upgraded to a Category 5 s≤ >torm by NOAA in April∏≠₽. Florida officials have repeatedly∞α∑ called on the insura&✘$nce industry to speed up the recovery process, wλ₩ith nearly 12% of claims still open a year ↓✔after the storm hit.OrgΩα↔≤anizer：China Insurance Digital &a♠σ♣™mp; AI Development 2020Web:http://en.zenseeΩλ←group.com/p/560573/Contact:Ann 021-6←δ₽ 5650305
From:businessinsuranceeinsura→nce renewals at Jan. 1, 2020, mainly φ>>saw single-digit increases, with some excep"'$•tions, according to repo♠←•rts by reinsurance brokers released Thursdayα®αβ.Willis Re, the reinsurance brokerage o ®♦f Willis Towers Watson PLC,≈φ and Guy Carpenter & Co. LLC, a unit of Marsh & McLennan Cφσλos. Inc. both reported that ye★©ar-end reinsurance renewals v≤>®≤aried by account and region, but the retrocess≤∏✔ional reinsurance was under pressure.Rates on liΩ♠λne for property catastrophe reinsurance p∑&€rograms remained stable and property per risk pri↔₩₽cing was driven by individual✘€¥∏ program performance, the Willis report s✘€≠aid.Although some Lloyd’s♦₽ of London syndicates took firm positio₩£ns on rate increases and the London mar<"♣∑ket authorized capacity decreased, that capact¥φ↓iy was replaced by new capital and a str♣αong supply from other mar kets, Willis Re said.←≤ΩU.S. loss-free accounts renewed at fl'¥σat to up 10% while those wi"↓th losses saw increa₹<φses of 10% to 50%, the Willis Re repo♦↑∞rt said, which was among the largest increase×∑÷£s. Property catastrophe$α accounts without losses rene≥©♥wed at flat to up 5%, while loss hit acc≤∏≥↑ounts were up 10% to 20%, Willis Re φ☆Ωsaid.According to the Guy Carpe£←↔nter report, the brokerage’s global property cataσ¶strophe rate on line index rose 5% ÷§"γin 2019.According to the Willis Re report, other™β> large increases were seen in Centra↑≠"&l and Eastern Europe, wher≤βe property programs with losses saw Ω↕Ωincreases of 5% to 20%, and Ca"∑'¶nada, where such accoun'>ts renewed up 10% to 40%.Most oth✘→ er regions and countries saw property inc∑ reases in the single or low double digits, tβ™→he report said.The Jan. 1 renewals saw some “diff←↑λ€icult” negotiations, according to a letter in the£✘ report from James Kent, global CEO, W"¶illis Re.The Guy Carpenter±γ∞± report said the reinsurance market wa$←$s “asymmetrical,” ad♠→✘ding “this is certainly not a∑×∏ one-size-fits-all market” a≠₹δnd while overall capac®&ity remained adequat↓>e, “allocated capacity tighten£λ•ed notably in stressed classes.”Dedicated±≈ reinsurance capitalλ♥ rose 2% in 2019 and≠∑♦÷ the year saw approximately $60 billio♠€♣n in global insured catastroph¥×±e losses, according to Guy Carpenter,¥$ which was significantly lower than 2≤≥017 and 2018.Alternative capital,קε∞ however, contracted by λ"≠approximately 7% percent “as investors&β> were more cautious with new inve&₽±stments after assessing market ∞& dynamics and pricing adequacy,” ±↓Guy Carpenter said.The retrocessi♥<∞on market “was challenged … by trappe₽¶d capital, a lack of new capital and continδ&♥ued redemptions from third-party capital pro∏₽Ωviders,” a statement issu©®ed with the Guy Carpen★™∑ter report said.However¶§→©, significant retrocession providers re÷®✘turned to the market →in the past two weeks, Willis Re said.Or"∏ ganizer：China Insurance Digitaλ™λl & AI Development ☆≠©2020Web:http://en.zenseegrou↓Ω←p.com/p/560573/Contact:Ann 021-65650305
Major information technology companies in In>≠±αdia are running the risk of termi☆ nation of their $1 billion c>¥ontracts following Boeing Co.’δ≈♥<s decision to halt the production of i↔∑δ'ts 737 Max jets, MoneyControl repoα"♠rted citing the Business Standard. Companα♥¥ies like Tata Consulta≠ε↓ncy Services Ltd., Infosys Ltd., HCL Technologie££αs Ltd., Cyient Ltd. and L&T Tech€★₩nology Services Ltd. have outsourcing contractsλ with Boeing or its s÷γuppliers and Boeing’s jet crisi"→s is expected to affect these IT companies in∑↓ the short run.From:businessi&✘£nsuranceOrganizer：Ch£↕ina Insurance Digital & AI >Development 2020Web:http://en.zense"λ↔<egroup.com/p/560573/Contact:Ann 021-6☆☆5650305
France-based eyewear m> •$aker Essilor Interna★☆tional S.A. has discovered fraudulent activiti↔♠es at one of its factories Ω♦σin Thailand that could ca♥±use €190 million ($213 million) ★↕in financial losses to the company, The Irish ε£✘ Times reported citing Reuters. Tεδεhe company has filed complaints in Tha↔€iland and has fired all the involved employe¶£es. It hopes to recover the losses from frozen ba ←nk accounts, insurance and lawsuitφπs.Organizer：China Insurance Digital &aγ₽δ¥mp; AI Development 2™γ020Web:http://en.zenseegroup.com/p/560573/Cφ↕←≤ontact:Ann 021-65650305
