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- Pliant Therapeutics Announces Str±∞πategic Collaboration to Develop Novel Therapi ₹©βes for NASH and Fibrotic Diseases
Pliant Therapeutics Anγ "✘nounces Strategic Coll✔φaboration to Develop Novel<λ¶ Therapies for NASH and Fibrotic Dis✘★♣→eases
THURSDAY, OCTOBER 24, 2019
Pliant Therapeutics, Inc.&∑, a clinical stage biopharmaceut ↕ical company focused on discovering an€d developing novel therapies f←↑↔or the treatment of ™€↕fibrosis, today announced it has★✔ entered into a strategic collabor€♣ation and license agreement ☆∞®with Novartis coverin↓ g the development and commercialization←∏ of Pliant's preclinical product candidaσ∞ te, PLN-1474 and up to thre↓←e additional integrin tarφ×←÷gets. PLN-1474 is an internally disγ×covered small molecule selec"♣tive inhibitor of integrin αVβ1,≈∏¥ currently being developed for the trea★♥γ©tment of liver fibrosis associated with n'$onalcoholic steatohepatitis (NASH).
"Our research continue↔•s to generate compelling p↓×Ω™reclinical evidence thα$∞↑at supports the advancement of PLN-1®γ↔474 as a clinical candidate and validates our σapproach of evaluating αVβ1 integrin inhi£✘bition to treat advanced liver fibrosis assocφ≠÷iated with NASH," said Be₩ε γrnard Coulie, M.D., Ph.D., president and chie≠≥f executive officer of Pliant Therapeuti₽cs. "Pairing Pliant's leading integr'↕in biology and drug discov ery capabilities with Novartis, a world-leade≈∏∑r with one of the br ₽ ™oadest pipelines investigating mono and comε bination therapies for liver d∞₩≠™iseases including NASH, will↕πσ support our goal of developing novel thera↑♣¶♥pies for fibrotic diseases and poΩα¶tentially bring meaningful treatment≠φ× options to patients."
Pliant will initiallyδφ receive $80 million from NovΩ↑δartis, including an upfront payment in conneα↑"★ction with the collaboration agree ☆→÷ment as well as equit¥↔y investment commitments. The collaboration agr ¥♦eement is for a worldwide exclusive license to ↕↔₩PLN-1474 and up to three additi♥÷onal product candidates gene$₽¶→rated under the collaboration. In addition, N↓ ovartis will fund Pli☆φ™ant's research and development activities under t₩¶he collaboration. Pliant will be↑ε✘ responsible for developm♣↓ent of PLN-1474 through Phase 1 aftεδ↓er which Novartis will assume responsibility ↓♦for all future development, manufacturing↕Ω♣ and commercialization. Pαφ≥liant is eligible to earn milest↔σone payments, conting§<ent upon the achievement of specified d±φevelopment, regulatory and γ→<≈commercial milestones. The a♦¥greement also provides f¥β™or tiered royalties payable to Pliant ra∏ ≠•nging from the mid-single digits δ to low double digits on product sales upon comm¥α™♦ercialization. The transaction is subject♣₽ to customary closing conditions, including cl↕¶earance under the Hart-Sφ∞"cott-Rodino Antitrust I÷€mprovements Act.
NASH associated cirrhosis is the '"fastest growing indication for liver transplantaφγ≈Ωtion in the United Sta♠✔¥tes. Many patients with NASH deve₩$ lop associated liver fibrosis, wh₽"ich can lead to compl✔ ications such as cirrhos≈¥¶ is and ultimately live↓¥∏r failure. While severalσ©¥≈ investigational agents target mechaβ↔↓"nisms that impact th♦β↓&e earlier stages of the NASH continuum, Pliant ♣∞¥is targeting αvβ1, an i÷ε"ntegrin that activates TGF-β, a putative maλ&®ster regulator of hepatic fibrosis. PLN-1γ≈474 has shown significant inh≥λ•÷ibition of fibrosis in live human±$ tissue models. Pliant exp₹ects to submit an investigational new d♣→∏rug (IND) application to the U.≤✔β≠S. Food and Drug Administration before the end ✘↑of 2019.
information source:pharma focus Asia
The original link:https://w€ww.pharmafocusasia.com/news/pliλ'✘ant-therapeutics-ann¶∞ounces-strategic-collaboration-to-develop-no¶™∏vel-therapies-for-nash-a≥₹nd-fibrotic-diseases
2019 Asia-pacific pharma IP Leader Summit: http://en.zenseegroup.com/p/510934/ will be held in Beijing on November 14-15, and will attract more than 500 indu÷&₽stry experts from domestic and foreign pharmaceut♠£ical companies, bioteφ≤≠chnology companies, governments, associaα¶↔tions, law firms, intellectual propδ>erty agents and other companies to attend.
Official registration and ✔±consultation channels:
Contact：Ann
Phone: 021-65650305
Email：Marketing@zenseegroup.com
http://en.zenseegroup.coσ m/p/510934
From :businessinsuranceU.S. commercial property/c"asualty rates rose 5% on average in the fourthγΩ≠ quarter of 2019, up fr¥<om 4% in the third quarter, reflecting inεσ&surers’ intent to continue to increas₹β♣δe prices across most lines, online inπ≈©surance exchange MarketScout Corp. said Monda←Ωφ§y.“Auto rate increases have been↓→∑ up all year long; however D&O (d↕&↔ irectors & officγ¶ers) and professional ra÷&✘te increases have spiked si$↕gnificantly in the fourth quarter,” Richardδ↑ Kerr, CEO of MarketScout C≠•∑orp. said in a statemen¶₩<t.Insurers are carefully analy>♣'zing their property exposures u↔ε♠sing catastrophe modeling tools, he said™Ω♠. “We expect many of the major property catast>♥rophe insurers to curtail thei¥♦>εr 2020 writings in Californσ∑→γia brush and East an±↔d Gulf Coast wind areas. Na₩ turally, this will result in ®÷σhigher rates to insureds,” Mr. Kerr said.D&O↑ ↕ liability rates incr " eased by 8.25%, while commercial auto increased 8♦ φ% in the quarter, and professional liab®§ ↔ility rates were up 6%, and•↕↔↓ umbrella/excess rates were up 5.5%, accordi↕↔✔ng to MarketScout.Commerc✘♠ial property rates inc✘∑₹reased 5.25% in the quarter, and business in ↔terruption rates were up 5%, while all ₽ other lines showed smaller increases, &€←except for workers compensation, where ÷∞<rates fell 1%, MarketScout said≥£∏.By industry class, tra✘✘nsportation and habitational saw the ∏highest average rate increases at 9% and 8.2•≈≈>5% respectively, MarketScout sai₩&σd.Large accounts – those with $250,001 ∑πto $1 million in premium – saw<Ω• a rate hike of 5.5% in the fourth quarter, α→as did jumbo accounts, which have mo€★re than $1 million in premium. Smal↓λl accounts – those with up to $25,000 in p₽÷®♣remium – were up 5%, while medium a♠§≤ccounts – those with $25,001 to $250∞✘©>,000 in premium – were up 4.5%.The “¶£₽♦steady trend” of upward rates reflect✘♠✔s insurers’ plans to c✔♣¶ontinue increasing prices across all lines exλ₹λ cept for workers compensation, MarketSc ↕out said.Organizer：China Insurance Digital↕& & AI Development 2020WeΩ♥b:http://en.zenseegrou±€λp.com/p/560573/Contact:Ann 021-65650305
From :insurancejournalIt was a ∑₹relatively quiet year©β $ for the Southeast in terms o'•$f major catastrophes compared with 2018 when ♠Hurricane’s Michael and Florence caus↕✘✔↔ed major damage in the region. T♦∞πhis year, Hurricane Dorian sideswiped the So✔λφutheast coast and made landε↑fall on the Outer Banks of ≤→North Carolina but most of the area wasφ¥¶÷ spared. Still, Aon said economic damage in >""the U.S. and Canada was poised to₹αα↑ approach a combined $1.5 bi¶±llion.Florida spent the year ε¥recovering from Hurricane Michael, which w∞∑↕as upgraded to a Category 5 sto' 'rm by NOAA in April. Florida officials have $≥repeatedly called on the insura♣←nce industry to speed up the recovery proces™<s, with nearly 12% of claims still♦♦ open a year after the•€™ storm hit.Organizer：Cπ∞hina Insurance Digital & A÷£I Development 2020Web:http://en.zenseegr↑§oup.com/p/560573/Contact:Ann 021-65650∞♠∑←305
From:businessinsuranceeinsurance renewals at J≈∑an. 1, 2020, mainly saw single-digit inc♥✘reases, with some exceptions, according to repoγ&≤♥rts by reinsurance brokers≈ released Thursday.Will≠✘✔•is Re, the reinsurance brokerage ≤δof Willis Towers Watson PLC, and Guy Carpenter©™♠∏ & Co. LLC, a unit of Marsh & Mc←★Lennan Cos. Inc. both reported that year$γ -end reinsurance renewals varied by acco∞±unt and region, but the retrocessiona ✔σl reinsurance was under pressure.Rates on liγ&ne for property catastrophe ™↓reinsurance programs remained stable and p♦♠roperty per risk pricing was driven by indivi'☆dual program performa∏∞γnce, the Willis report said.Although↓ >★ some Lloyd’s of London syndicates too£↔©k firm positions on rate incrφ↔✔eases and the London market authorized capa↑'city decreased, that capactiy was replacedπ≥ by new capital and a strong suppl¥λy from other markets, Willis©α Re said.U.S. loss-free accounts renewed at flat © to up 10% while those✔€φ∏ with losses saw increases o©↑¶f 10% to 50%, the Willis≥©≠♦ Re report said, which was amo≈±®ng the largest increases. Property cat✔σastrophe accounts wi♥Ωthout losses renewed at flat ♦∑♦πto up 5%, while loss hit a÷ ccounts were up 10% to↓ ↑ 20%, Willis Re said.According to ♦ ♦♦the Guy Carpenter report, the brokerage’sλ☆ Ω global property catastrophe rate∑" on line index rose 5% in 2019.A$£ccording to the Willis R∞e report, other large incre✘¶ases were seen in Central and ♥σ ¥Eastern Europe, where properγΩty programs with losses saw i εncreases of 5% to 20%¥♣×, and Canada, where such accounts renew↓•ed up 10% to 40%.Most other re÷ •αgions and countries saw property increases in th®≥≤e single or low double digits, t >he report said.The Jan. 1 σ↔£renewals saw some “difficult” negotiations, accor♣÷ding to a letter in the report fro☆↑×≤m James Kent, global CE≤↑♦εO, Willis Re.The Guy Ca≥εrpenter report said the reinsuran∞αce market was “asymmetrical,” £δεadding “this is certainly not ♥π¥a one-size-fits-all market” and whilδα&e overall capacity re↔<₽γmained adequate, “allocated capacity tigh"±≥tened notably in stressed★☆ classes.”Dedicated reinsurance capital ros ™↓$e 2% in 2019 and the year saw approxim↔§εβately $60 billion in global insured catas÷trophe losses, according to Guy≤γ↔ Carpenter, which was significantly →™lower than 2017 and 2018.Alternative capita$ l, however, contracted by'✘ approximately 7% percent “as invest→>αors were more cautious with new ♦✔↑<investments after as←¶sessing market dynamics λ¶ and pricing adequacy,” Guy≤≥∞₹ Carpenter said.The retrocession mark♥β↑et “was challenged … by trapped capital, a l↓♦δ£ack of new capital and continued redemptionsλ∞ from third-party capital providers,” a∏™÷ statement issued with the Guy Carpente'₹r report said.However, sign↓$←$ificant retrocession pr§>€oviders returned to the market in th☆₹ ∏e past two weeks, Willis Re said.Organizer：China₩± Insurance Digital & AI Development 2020Web:×α≥$http://en.zenseegroup.com/p/560573/Contact:Ann ©γ₽021-65650305
Major information technology companies in India aγ ☆✔re running the risk of termination of the↔♠"ir $1 billion contracts f"& ollowing Boeing Co.’s $★decision to halt the prod×↔uction of its 737 Ma✘≈x jets, MoneyControl reported citing the B←♦usiness Standard. Companies like Tata Con∑β≠ sultancy Services Lt↕↔•d., Infosys Ltd., HCL Technologies Ltd.,σ♦↔× Cyient Ltd. and L&T Technology Service♠∞πs Ltd. have outsourcing contracts ≥★with Boeing or its suppliers and Boeing’s≠★¥& jet crisis is expected to affect★$ these IT companies in the short ←Ωrun.From:businessinsuranceOrganiz←♦er：China Insurance Di✘σ$gital & AI Development 2020Web:http://en↔×★.zenseegroup.com/p/560573/Co∏≠ntact:Ann 021-65650305
France-based eyewear maker Essilor Inter♥¶national S.A. has discovered fraudulent ac©✘tivities at one of iφ₩☆ts factories in Thailand that could cau≥€εse €190 million ($213 million) in financia>§<l losses to the company, The I≠βrish Times reported citing Rεeuters. The company has filed co∑¥mplaints in Thailand and has fired all >¥←£the involved employees. It hγ©opes to recover the losses frλφom frozen bank accounts, insuranc☆↑e and lawsuits.Organiz§₩≥→er：China Insurance Digital & AI D✘ε≥evelopment 2020Web:http://en.zenseegroup.com/p/56©✘₽0573/Contact:Ann 021-65650305
