WEDNESDAY, OCTOBER 23, 2019
PDS Biotechnology Corporation, a clinical-sβπ&tage immuno-oncology company pioneer₽÷ing development of multi£ε£♥-functional novel immunotherapiesγ<, today announced tha£≠♠t it has completed manufacturing of clinical baβ↔∏¶tches of PDS0101 with its partner BSP Phaπ₽¶✔rmaceuticals S.p.A, a leading ¥₽★×manufacturer of anticancer drugs.
The clinical batches of PDS0101 will ♣♣be used in the Company’s ≠§two upcoming Phase 2 studies, which are expected to start in the first quλ★&φarter of 2020. The trials includ÷∞e a combination study with Mer©©ck to evaluate PDS0101 in combinati←§'on with KEYTRUDA® in first-line treatment of↑♠>≥ head and neck cancer and a study t<♦o evaluate PDS0101 in combination with ¶γ♠two novel clinical-stage immunothera€∑≈→pies in advanced HPV assoc♦₽iated cancers with the National Cance'₹→€r Institute.
“We are pleased to have∏> completed the manufactu♥$☆γring of the clinical batches↓& of PDS0101 with our partner BSP P∞↕harmaceuticals and ar↓÷e honored to be collaborating with two↑≥×∞ leaders in the field of immuno-₩↔ ±oncology,” said Dr. Frank Bedu-Addo, CEO of PDS. ★₩“Based on our recently announced Phase 1 clini∑✔cal outcome data which demonstrated PDS0101’s un¥₩₩ique ability to promote the in-vivφ☆₹o induction of high levels of HPV♦≤×-specific CD8+ killer T-cells as we≠>✔πll as the regression of pre-canc € erous lesions in 60% of αε'←patients, we believe that PDS0101 could™ expand the clinical ≤✔efficacy of checkpoint inhibitors Ω♥such as KEYTRUDA®. We ar✘₽φe now working diligently to qualifyφ" clinical sites for our combination trial witσ•¶↔h KEYTRUDA® in first line treatment of h∞→ead and neck cancer and look fo€™rward to initiating both o≠αur planned combination trials by the first quarte₩₩r of 2020.”
information source:pharma focus Asia
The original link:https:/₩✔/www.pharmafocusasia.com/neε←₹ws/pds-biotechnology-complete✘φ¶£s-manufacturing-of-clinical-batches-of-pds010∏§1
2019 Asia-pacific pharma IP Leader ®¥σSummit: http://en.zense↔×£egroup.com/p/404716/ will be held in Beijing on November 14-15, and will attract more than 500 industry£₩¥β experts from domestic and foreign pharmaceut&→π™ical companies, biot∞echnology companies,¥©← governments, associations, law fir✔®♠ms, intellectual property agents and other co©↑mpanies to attend.
Official registration and consultation chan↓¶✘ nels:
Contact:Ann
Phone: 021-65650305
Email:Marketing@zenseegroup.com
http://en.zenseegroup.com/p/510934
From :businessinsura↓∞€↕nceU.S. commercial property/casualty rates rose 5β®% on average in the fourth quarter of 2 ≤↓019, up from 4% in the third qu₽∑"arter, reflecting insurers’≈↓π intent to continue to increase pr★>ices across most lines, online insurance ex≥₹¶change MarketScout Corp. said M¶÷★onday.“Auto rate increases have been up a&'$ ll year long; however ₽D&O (directors & officers) Ω φ♣and professional rate increases have sp&δΩiked significantly in the fourth quart™♠er,” Richard Kerr, CEO of MarketSc♦'out Corp. said in a stat ♠ement.Insurers are carefully analy zing their property exposures us₽↑↑≥ing catastrophe modeling tools, he said. “We expe∞ βct many of the major property catastrophe insurerβ"s to curtail their 2020✔™φ™ writings in Californi"Ωa brush and East and Gulf Coas←β₹t wind areas. Naturally, thi<±♥s will result in higher rates to♥↔σ insureds,” Mr. Kerr said.D&O± " liability rates increased by 8.2≈£§¥5%, while commercial auto in±₹∑creased 8% in the quarter, ×✔and professional liability rates were up 6%, and€α∞ umbrella/excess rates were up 5.5%, acc™$ording to MarketScout.Co$↑mmercial property ratesσ ↑☆ increased 5.25% in the quarter, and busi£ ness interruption rates were up 5%, while all o₩&ther lines showed smaller increases, e¥Ω ♣xcept for workers compensation, wh©≥≈ere rates fell 1%, MarketScout said.∏•"♦By industry class, transp♦$≥γortation and habitational saw the highest average≥¶φ rate increases at 9% aε nd 8.25% respectively, Marke≥÷♠tScout said.Large accounts – £§αγthose with $250,001 to $1 mi©®®☆llion in premium – saw a rateδ₹ hike of 5.5% in the fourth qua'®¥₹rter, as did jumbo accounts, which have m↓♦εore than $1 million in premi "um. Small accounts – those with up to $25↕ ,000 in premium – were up 5%, while m→λ×edium accounts – those with $25>★λ,001 to $250,000 in premium – were up 4.5%.Thφ✘e “steady trend” of upward rates reflects insur¥←☆ers’ plans to continue incr≈₩δeasing prices across all lines exceφ★"pt for workers compensatio∑≈n, MarketScout said.Organizer:China Insuran'↔ce Digital & AI Deγγ≈velopment 2020Web:http:/±¥←/en.zenseegroup.com/p/560573/Coδ&&ntact:Ann 021-65650305
From :insurancejournalIt was a rela↕→≤tively quiet year forφ•↔ the Southeast in terms of major ca♣φδ✘tastrophes compared with 2018 when Hur<≈→×ricane’s Michael and Florence caused major daσ≈λmage in the region. This y γ±ear, Hurricane Dorian sideswiped the S>✘Ω outheast coast and made la×±ndfall on the Outer Banks of North Carolπ"ina but most of the area $±¶was spared. Still, Aon said economic ✘≥damage in the U.S. and Canada was poised÷< § to approach a combined $1.5 billion.Florida spen♠ ≤•t the year recovering &δ≥↑from Hurricane Michael, which <¶;was upgraded to a Category 5 storm by±→ NOAA in April. Florida officials haveσ∑≥ repeatedly called on the ♠₩insurance industry to speeΩ≠d up the recovery process, with neσ✔©arly 12% of claims still open a year after the↔→ storm hit.Organizer:Chβ≈↔ina Insurance Digital & A∏↑≥I Development 2020Web:http://en.₹↔zenseegroup.com/p/56057Ω≤3/Contact:Ann 021-6565€≈↑0305
From:businessinsuranceeinsurance renewals §♠at Jan. 1, 2020, mainly saw sing¶β≥→le-digit increases, with some exceptions, accord≈€"ing to reports by reinsurance ¶•∑brokers released Thursday.W $illis Re, the reinsurance brokerage of<♣ ≤ Willis Towers Watson PLC, and Guy Carpen©λter & Co. LLC, a unit± § of Marsh & McLenna×₩β♦n Cos. Inc. both reported tha•"↓t year-end reinsurance renewals vari₩♦σed by account and region, but the retro☆™δcessional reinsurance ∏₽was under pressure.Rates on line for₹☆★✘ property catastrophe reinsuranc£λe programs remained stable and property per ris↑←₹k pricing was driven by individual program ✔ performance, the Will₹ ¶λis report said.Although some Lloy&£αd’s of London syndicates took §∏firm positions on rate increases and the Lπ§γ↓ondon market authorized capacity decr< eased, that capactiy was replaced by new capita§$l and a strong supply from other markets, © <≥Willis Re said.U.S. loss-free account↓ s renewed at flat to up ≥₩δ10% while those with losses saw increasβ₽"es of 10% to 50%, the Willis Re report said, ♥>™which was among the largest increase↓¥&s. Property catastrophe acc$<₹ounts without losses renewed at flat t¶→o up 5%, while loss hit accounts were up 10% to 2™∏&0%, Willis Re said.According•₽ to the Guy Carpenter report, •↕©÷the brokerage’s global p>®roperty catastrophe rate on line i♠πndex rose 5% in 2019.According to the W×™≤§illis Re report, other large in∞creases were seen in Central and Eastern Eu÷rope, where property programs wσ₽ith losses saw increases of ♦ 5% to 20%, and Canada, ∞ where such accounts r∑<↔enewed up 10% to 40%.Most other regλ≠ions and countries saw property increas•←>es in the single or l÷→ow double digits, the report said.The Jan. 1 r αenewals saw some “difficult” negotiati'πβons, according to a letter in the report fro✔×★m James Kent, global CEO, Willis Re.The Guy Carp&≈enter report said the reinsu<÷♥rance market was “asymmetrical,” adding “t↓σ his is certainly not a oneλ×®•-size-fits-all market” and whiδ∑γle overall capacity remained adequate€♥©δ, “allocated capacity t↓♦ightened notably in γ→&stressed classes.”Dedicated reinsurance ca✔≈→ pital rose 2% in 2019 and the year sa™←±w approximately $60 billion i→↓☆n global insured catastrophe losses,∞↕ according to Guy Carpenter, which♦₹₩• was significantly lower th✔←an 2017 and 2018.Alternative capital, how¶∏↔ever, contracted by approximately 7% percent “®¥as investors were more cφ≠€εautious with new investments after ¥εassessing market dynamics and pricing adequacy×"€,” Guy Carpenter said.The r✘® 'etrocession market “was challe&βnged … by trapped capital, a lack of new capi<♦₹tal and continued redemptions from third-part♠₽✔y capital providers,” a statement issue↓←✔d with the Guy Carpenter₩♥♠ report said.However, significan€φ♥♣t retrocession providers returned to the markeλ≠t in the past two weeks, Willis Re sa→♠♣id.Organizer:China I₹> nsurance Digital & AI Developme×∏±nt 2020Web:http://en.zensee£☆×group.com/p/560573/Contact:Ann 021-65650305
Major information technology companies i₽✘n India are running the risk of ter→₹©☆mination of their $1 ★§≥billion contracts foαδε₹llowing Boeing Co.’s decision to halt the γ×≥production of its 737 Max jets∞₩, MoneyControl reported $ citing the Business Standard. Companies like Tataαφ Consultancy Services≈≈ Ltd., Infosys Ltd., HCL T÷λ☆☆echnologies Ltd., Cyient Ltd. α↑¥and L&T Technology Services Ltd. have outsou↕×&€rcing contracts with Boeing π≥✘™or its suppliers and Boeing’s jet crisi€>λ♦s is expected to affect these IT companies in t$✘≥he short run.From:businessinsuranceOrg∞±anizer:China Insurance Digital & A<×★★I Development 2020Web:http://enαα.zenseegroup.com/p/560573/Contact:A ↕♥$nn 021-65650305
France-based eyewear maker Essilor Internation↕✔al S.A. has discovered f♠εΩ raudulent activities at one of its factories i± δn Thailand that could cause €190 δ©₹million ($213 million) in financial losses to the∑☆ company, The Irish Times ←φγreported citing Reuters. The c↑<✔ompany has filed complaints in Thailand §Ωεand has fired all the involved employees. &π÷✔It hopes to recover the losses from≈↕ frozen bank accounts, '±★insurance and lawsuits.Organizer:China Insuranc♣☆e Digital & AI Development 2020Web:http://en¶&÷≥.zenseegroup.com/p/560573/Contact:Ann 021-656 ✔ε€50305