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- ProBioGen Licenses GlymaxX® Technology toδ"• Bayer
TUESDAY, SEPTEMBER 10, 2019
ProBioGen AG, a premier service aδ→♥nd technology provider for complex ♦&therapeutic antibodies and gl↓☆€ycoproteins, today announced the closin♣↕₽g of a license agreement with Bayer AG for the∑ GlymaxX® Technology. U★↑nder the terms of the agreement, Bayer will↔α leverage the technology to furthe±✘ πr increase the potency of an unσ✔disclosed antibody candidate for oncological ind ↓σications.
ProBioGen’s proven antibody-depende♦₹nt cellular cytotoxi£✔≈÷city (ADCC) enhancing technology GlymaxX® wiπ →ll be applied during cell line developπ¶ment.
“We are glad to add Bayer to our list of licen¶$¶sees”, says ProBioGen←φ’s Chief Executive Officer Dr. Wieland Wolf. “Th©✘e GlymaxX® technology is c★↕↔$linically proven and is a very flexiγ♦λble technology which is liked by £₹all cell lines.”
About ProBioGen AG
ProBioGen is a premier, Berlin-basedδ★φ' specialist for developing and manufacturing §↓≥complex therapeutic antibodi★★₽es and glycoproteins. Combining both state-of-t™≠he-art development services, based on ProBioGen’£≥s CHO.RiGHT™ expression aβ±♥nd manufacturing platform, ∞>≥together with intelli$φσgent product-specific technologies yields bio•δ logics with optimized properties.
Rapid and integrated cell liβφ±ne and process development,&→ comprehensive analytical developme£↔∞nt and following reliab¶<•le GMP manufacturing is performed by a highly ski♥✔lled and experienced team.
All services and technologies are embedded in a total qualit<→$×y management system to assα™ure compliance with international ISO and GM<P standards (EMA/FDA).
ProBioGen was founded 1994, is priv♠•ately owned, and located in ∑&∑Berlin, Germany.
About GlymaxX®
The GlymaxX® technology, deve¥γ€loped by ProBioGen, prevents the cellular synthe±σ≈εsis of the sugar “fuc€♠ose” and hence, in antibody-producing ♥cells, its addition to the N-linked carbo"¥hydrate part of the antibo★<dy. The absence of fucose is known toεδ greatly enhance ADCC♦★. The GlymaxX® technology is based ₩≠ on the stable introduction o©<₩f a gene for an enzyme which blocks the produc♣ε♠♥er cells’ fucose bios≤ ynthesis pathway. As a unique∑₽ feature, differentiating it from other approach±"γes, GlymaxX® can be applied to both novel ₽₽ or already existing antibody producer γ±↑♥cell lines, and entire antibo♠'πdy expression and disc↕÷∏δovery platforms, without negatively aff φecting their productiΩ¶vity or other product↕♠ characteristics.
Furthermore, a single GlymaxX® cell↕€¥ line can be flexibly used to produce differe←ntly fucosylated products, depending on the upstr≠eam process: In fucose-free medium the antibo£ >dy is quantitatively afucos÷ε ylated. The same Gly↓₽∏≠maxX® cell line grown in fucose-containing medi§€um however, uses the prov±₹÷ided fucose and produces fully≤§¥ fucosylated antibody. Thu∞∏× s, a GlymaxX® cell line can by employed to ±∑produce different products: For instance A↔≥DCC-enhanced GlymaxX® antibodies or wild≠™£type-like, fully fucosylated mAbs, for a paralle♣l Antibody-Drug-Conjugate (AD♥εC) project.
Finally, GlymaxX® has been used by bios€±♦"imilar-developing companies♥¥ to adjust a specific content of fucose σαin order to match the originators glycoproλα♠file. Overall, GlymaxX® is simple, rapi<&d, potent, and universally applicable to differenλ∏t CHO hosts and all other eu"πkaryotic cell specieπβ♣s.
ProBioGen offers its Gly→×maxX® technology royalty ®×-free and non-exclusively ≥✘as a service or as an individual license.
2019 Asia-pacific phaφ$÷rma IP Leader Summit:http://en.zenseegroup.com/p/λΩ✔510934/will be held in Beijing on November 14-15, and will attract more than 500 ©↓industry experts from✔∑δ• domestic and foreign pharmac✔∑¶eutical companies, biotechnology com≠¥panies, governments, associations, law firms, Ω÷€intellectual property agents and other∏Ω∑® companies to attend.
Official registration and consultati≠'on channels:
Contact：Ann
Phone: 021-65650305
From :businessinsurance∏♠γ"U.S. commercial property©≥/casualty rates rose 5% on average in the f♣☆¥♣ourth quarter of 2019, up f×γ₹rom 4% in the third quarter, reflecting inφεsurers’ intent to continue to incrλ ease prices across m♣✘ost lines, online insurance exchange Mar♣¶ketScout Corp. said Mo £≤nday.“Auto rate incr →eases have been up alπ<£<l year long; however D&O (dγ↔♥irectors & officers) and professi₹✔€εonal rate increases have spiked >↓☆significantly in the fourt♥•≥h quarter,” Richard Kerr, CEO of MarketScout Corp ≈. said in a statement.Insuδ÷₩♦rers are carefully analyzing their property expo≤sures using catastrophe m♦φ€odeling tools, he sai→ ♥d. “We expect many of t∑↓₹he major property catastrophe insurers to cur÷₽±÷tail their 2020 writings in Ca→₩lifornia brush and East and Gulf Coast wind are÷"≤₩as. Naturally, this will result in hig<✘♦€her rates to insureds,” Mr∏↑ <. Kerr said.D&O liability rates increas<φ¥ed by 8.25%, while commercial auto in↕λcreased 8% in the quarter, and professional liβ™♥ ability rates were up 6%, and umbrella/excess ra♥§tes were up 5.5%, accordin∑≈×≥g to MarketScout.Commercial property rates≤↑≥ increased 5.25% in the quarter, and busines € ♥s interruption rates were up 5%₽✘, while all other lines showed smaller increases,←γ™$ except for workers compensation, where ra®tes fell 1%, MarketScout said.By industry cl≠&¥ass, transportation and ha∑bitational saw the highest average ra∑"te increases at 9% and 8.25'÷% respectively, MarketScout said.Large accou ∞<∞nts – those with $250,001 tφ♥o $1 million in premium – saw a rate hike &of 5.5% in the fourth quarter, £α as did jumbo accounts, which ♥&have more than $1 million in premium. Small λφβ₽accounts – those with up to $25,000 in prem↕"φium – were up 5%, while medium accounts – those ✔βwith $25,001 to $250,000 in premium – were λup 4.5%.The “steady trend” of upwar₩ d rates reflects insurπ¶↕ers’ plans to continue increasing prε σγices across all lines except for α∞π workers compensation"₩, MarketScout said.Or≥↓ganizer：China Insurance Digital & AI Develo'×pment 2020Web:http://en.zenseegro₽∏βup.com/p/560573/Contact:Ann 021-65650305
From :insurancejournalIt was a relat↕♥÷ively quiet year for the Southeast in ♥↔≤terms of major catastrophes compared with>→δ 2018 when Hurricane’s Michael and Floren£♣&§ce caused major damage in the regio↓∞♣n. This year, Hurricane Dorian sideswipe♦λd the Southeast coast and made landfall on©↓₹ the Outer Banks of North Carolina but mos≠&¶t of the area was spar>γ•ed. Still, Aon said economic dama¶"ge in the U.S. and Canada was poε∑±Ωised to approach a c>₽≈εombined $1.5 billion.F✘←¶∞lorida spent the year recoverin&$g from Hurricane Michael, whπ☆≥ich was upgraded to a Categor÷♠★↔y 5 storm by NOAA in Apri♣§♥l. Florida officials have repeatedly&nb₹σ¥"sp;called on the insurance industry&→§ to speed up the recover'↔y process, with nearly 12% of claims still open≥ a year after the storm hit.Orga≈$≤ nizer：China Insurance Digital & A←©✘I Development 2020Web:http://en.zense× ✘∑egroup.com/p/560573/Contact:Ann 021-65650305
From:businessinsuranceeinsuran×✔ ce renewals at Jan. 1, 2020, mainly saw si§±ngle-digit increases, with some exception¶≠s, according to reports by reinsurance brokerε∑✘s released Thursday.Willis R> e, the reinsurance brokerage of Willis T•®'φowers Watson PLC, and Guy Ca∏¥rpenter & Co. LLC, a unit of Mars•→™h & McLennan Cos. Inc. both report£β±ed that year-end reinsurance renew♥γ'♦als varied by account and region, but↔♣ the retrocessional reinΩ®★→surance was under pressure.Rates on line↔$ for property catastrophe reinsurance program§✔s remained stable and property per ri↕&sk pricing was driven by individual pro≤☆₩→gram performance, the Willis report said.Aφ×<'lthough some Lloyd’s of Lond↑↑on syndicates took firm p∑'α≈ositions on rate increases and the London markeα₽t authorized capacity decreased, that∏®§ capactiy was replac∑∞ed by new capital and a strong supply fro ₽ m other markets, Willis Re saidε ©∏.U.S. loss-free accou≤≤↔σnts renewed at flat to up 10% while§< those with losses saw incr♦>eases of 10% to 50%, the Willisγ$& Re report said, which was among the large∞☆ ♥st increases. Property catastrαδophe accounts without losses renewed at f¶®£πlat to up 5%, while loss hit accounts were up±€ 10% to 20%, Willis Re said.Accord₩↕•ing to the Guy Carpenter report, the brokerage’s •♥∑global property catas'σ€ trophe rate on line index rose 5% in ↕÷2019.According to the Wil≥±€©lis Re report, other la ∞$rge increases were seen in Ce≤>קntral and Eastern Europe, w♦☆here property programs w ↕δ'ith losses saw increases of ← 5% to 20%, and Canada, where such accountsΩ€πβ renewed up 10% to 40%.Most other regions and cou'✔πntries saw property increases in the single or l γ♣ow double digits, the report said.Th✔'¥$e Jan. 1 renewals saw some “difficult” n< ¥egotiations, according to a letter in the &σ∏report from James Kent, global CEO, Wil∏∞lis Re.The Guy Carpente γr report said the reinsu☆®™ rance market was “asymmetrica♠π≤≤l,” adding “this is cert★±>ainly not a one-size-fits-all→£ market” and while overall '> $capacity remained adequ•φ₹≤ate, “allocated capacity×₹∏₽ tightened notably in stressed classes.”Dedic₩λε≈ated reinsurance capital rose®₩¶ 2% in 2019 and the year saw approx★↑£☆imately $60 billion in "★✘•global insured catastrophe l♥§♦<osses, according to Guy Carpenter, whi>÷★ch was significantly lower than 2♥×&∑017 and 2018.Alternative capital, however β≤↔, contracted by appro✘ε♦ximately 7% percent “as inves≤≤♣tors were more cautious with new investme<λnts after assessing market dyn₩≈amics and pricing adequacy,” Guy Carpenter said>✘.The retrocession market “was cha₩≠®llenged … by trapped capital, ↕×a lack of new capital and continued redemp♠↔tions from third-party↑§ capital providers,” a statement iss₩≈<φued with the Guy Carpenter repor ₩t said.However, significant retπ₽→§rocession providers ₹≈ returned to the market in ₹ the past two weeks, Willis Re said.Organizer：Cα §✔hina Insurance Digital & AI Development©≈♠ 2020Web:http://en.zenseegroup.com/p/560573/Co"✘'ntact:Ann 021-65650305
Major information techn™☆$εology companies in India are running the risk of ε÷termination of their $1 billion con≤¶ tracts following Boeing Co.’s decision to haφ≤lt the production of its 737 Max jets, 'σMoneyControl reported citing the § ↕Business Standard. Companies<₽" like Tata Consultancδy Services Ltd., Infosys Ltd., HCL Technologi€≤es Ltd., Cyient Ltd. and L&T Technol©≥ogy Services Ltd. have outsourcing λ≠¶contracts with Boeing or its suppliers♥§≥ and Boeing’s jet cri↔∏sis is expected to affec♣•t these IT companies in the short$× run.From:businessins'¶∏ uranceOrganizer：China In♣β☆surance Digital & AI Development 2020Web× ™:http://en.zenseegroup.com/p/560573/Contact:Ann 0±★≥21-65650305
France-based eyewear maker♠↓± Essilor International ≤'÷☆S.A. has discovered fraudulent activities a§©t one of its factories in Thaδ∏©©iland that could cause €190 million ($213 mil★↔lion) in financial losses to the♦γ♦✘ company, The Irish Times reported☆↔& citing Reuters. The c↑÷βompany has filed complaints in Thailand ≈←and has fired all the involved employee₩♥★€s. It hopes to recover the losses f↕®✘rom frozen bank accounts, insurance and laεε γwsuits.Organizer：China Insurance Digital &a∑±mp; AI Development 2020Web:http≠'://en.zenseegroup.com/p/560™™573/Contact:Ann 021-65650305
