- Home
- News
- Industry news
- Thermo Fisher Scientific Signs Agreement with Li★ ©✔lly Oncology for Companion Diagnosti♥€c to be Used with RET Inhibit•£or
MONDAY, SEPTEMBER 09, 20£☆ε≥19
Thermo Fisher Scientific today ann∏α±ounced an agreement with E≤li Lilly and Company for development of a co& ≈mpanion diagnostic that w&σill use the U.S Food and Drug Administratio>←₽n-approved, next-generation'' sequencing-based Oncomine D÷™→x Target Test to identify cert<£§ain non-small cell lung cancer (NSCεLC) and thyroid cancer patients who may be trea>αλted with Lilly's investigational therapy, LOXO-29¥↑2. Specifically, the test would be used with pat☆×✔•ients whose tumors harbor a rearr™¶anged during transfe¥£₹✘ction (RET) alteration. RET variants∑↑§$ are found in about two percent of NSCLC, ↕about 60 percent of medullary thyroid cancer (M≥TC) and up to approximaφtely 20 percent of other ×≠₹Ωthyroid cancers.
LOXO-292 is a highly selective and potent oral RΩ ✔ET inhibitor being studied by Lilly i↓πn a Phase 1/2 clinical tri≈αal for the treatment of advanced c♦ε•ancers that harbor activa ↔ting alterations of the RET kinase. Changes iπ→n the RET kinase, including fusions≤± and mutations, can caαβ use uncontrolled cell growth leading to tumor d✘₹®λevelopment. Cancers driven by such al'>α∑terations are mostly dependent✔↔$ on this singularly activ↕∞ated pathway, making them highly susceptible"♣ to small molecule inhi§≥πbitors.
"One of the biggest barriers ®✘π'to realizing the full power of pr♣ε<ecision medicine in onc¶←ology is having access to high-quality 倩>testing, such as next-generation sequencing-bas©×™ed tests, that identi×¥☆≤fy a broad range of clinically actionable alter>Ωεations, can be performed locally and allow ™¶<treating institutions to partλ€ ★icipate in this important step←£ in the evolving treatment paradigm," sai₹€&±d Anne White, president of Lilly Oncolog→ y. "With this agreement, we believe th≈ ≠™at more patients will gain access to high-♦ ♠quality tumor profil∏$®ing, identifying those with RET alterations pot≠♥entially suitable for LOXO-292 therapy, in$ ↑ addition to other alterations suitableδ¥φ for treatment with othλα♠er therapies."
Mark Stevenson, executiλ←∏→ve vice president and cε♠λγhief operating officer of Thermo Fisher γ✔Scientific said: "We are✔ pleased to enter into thφ÷is agreement with Lilly and↓± leverage our Oncomine ★↓platform as a means t £✔₹o quickly identify canc€₽αer patients who may benefit from this breakthr"<© ough therapy, even in cases of σ↓©limited sample availabi$£×♥lity. We are committed to working with o₹β✔©ur global pharmaceutical partners to he≥≈lp bring forth next-generatδΩφ∏ion sequencing-based com÷"↑panion diagnostics and best-i&↔'&n-class therapies that can have a profound impac¥>≤☆t on treating cancer pat÷>♦♦ients."
Under the terms of the agreement∑γ™↔, Thermo Fisher will r ≥βγetain the rights to commercialize the test in €¥&all markets, including the Unitπ'ed States, Europe and Japan. Once validat•÷γion is complete, Thermo Fisher will submit a sup©₹∞plemental premarket apprε↓♠oval (sPMA) application to the U.S. Food a✔&nd Drug Administrati↕¥on (FDA) to broaden the clinical claim→≥s of its Oncomine Dx Target Test.
The NGS test, which received FDA↔♠ approval in 2017, simultaneously scre ₹₹ens tumor samples for multiple gene varianαΩ♥ts associated with NSCLC, a subset o™γf which are utilized to identif✘≈>y patients who may be eligible for several <©∑§approved targeted theraε↕♠pies. It is covered in the United States by th₩¶e Centers for Medicare & Medicaid Services a£Ω≠nd a majority of the largest commerφ£"cial U.S. health plans. Oπ₽πncomine Dx Target Test is also appro★₩ved for reimbursement by the Japan Ministr§σ™y of Health, Labor and Welfare<☆©¥ (MHLW).
2019 Asia-pacific pharma IP Leader Summit: http://en.zenseegroup.com/p/510934/ will be held in Beijing on November 14-15, and will attract more than 500 industry e¥ xperts from domestic and foreign pharmace♥→←utical companies, biotechnolog₹β&y companies, governments, associ∞∞ations, law firms, intellectual property ☆σagents and other companies to atteβ±≥nd.
Official registration and consultation ch≥§§annels:
Contact：Ann
Phone: 021-65650305
From :businessinsuranceU.S. commercial pr≤∏✘ operty/casualty rates rose 5% ↓≤on average in the fourth q≥→∞¶uarter of 2019, up from 4% in the third q↕π✔φuarter, reflecting insurers’ intent &÷β to continue to increase prices across m∞✘ost lines, online insurance exchangeφ® MarketScout Corp. sa₩←id Monday.“Auto rate incre ≈←•ases have been up all year long; however><γ× D&O (directors & officers) and πΩprofessional rate increases have∏±≤¶ spiked significantly in the fourth qua♣€₩rter,” Richard Kerr, CEO of Markeש↔÷tScout Corp. said in a&←" statement.Insurers arεδ¶↑e carefully analyzing their ÷ property exposures using ca↕ ≠♣tastrophe modeling too ∏ls, he said. “We expect many of theλ major property catastrop☆"♥he insurers to curtail their 2020 wriπ₹tings in California brush and East and Gul↔δ♦♦f Coast wind areas. Naturally, ™☆§σthis will result in higher rates to insure ≈&≈ds,” Mr. Kerr said.D&O liability rates ≤πincreased by 8.25%, ∏∑βwhile commercial auto inc←♣reased 8% in the quarter, and prof÷βessional liability rates were up 6%, and umbrella/excess rates were uΩ®p 5.5%, according to MarketSco>✔≠∏ut.Commercial proper Ωty rates increased 5.25% in the quarter, and bus§•₽iness interruption rates ≤♥↓®were up 5%, while all other lines≠ α showed smaller increases, excepσφ↓t for workers compensati γ↔on, where rates fell 1%, Mark<♠≠etScout said.By industry class, t≤♥¶ransportation and habita♠&♠tional saw the highest average rate inc× £→reases at 9% and 8.25% respecti✔∏vely, MarketScout said.Large acco&∑unts – those with $250,001 to $1 million i↔→Ω'n premium – saw a rate hike of 5.5•↓% in the fourth quar≈>∞εter, as did jumbo accounts, which have✘<♣ more than $1 million in premium. Small accounts >♠₹– those with up to $25,0<>±00 in premium – were up 5%₽ ♦, while medium accounts – tho✔§se with $25,001 to $250,000 in premium – were∏€ up 4.5%.The “steady trend” of upward rat €σσes reflects insurers’ plans to continue increasing prices across all lines except∑★α for workers compensation, Mar§→←↔ketScout said.Organize¥εr：China Insurance Digital & AI Deve✘₽lopment 2020Web:http://en.zenseegroup.co>$"m/p/560573/Contact:Ann 0≥ ±$21-65650305
From :insurancejournalIt was a relatively quiet y"π←♦ear for the Southeast♣©₹ in terms of major catastrophes compared with ≤ 2018 when Hurricane’s Micha∑≥™♠el and Florence caused maβ♣jor damage in the region. This year, Hurrica"≥ne Dorian sideswiped the Southea© ∞±st coast and made landfa ≥ll on the Outer Banks of North Carolina but m↔≠ ost of the area was spared. Still,&nb≥δsp;Aon said economic damage in th₹← e U.S. and Canada λ±;was poised to approach a comb→☆♦♦ined $1.5 billion.Florida spent the↔ year recovering from Hurricane Mich♠♦ael, which was upgraded to a Cateα↑gory 5 storm by NOAA in Apr'§β×il. Florida officials have re<>peatedly called on the insurance industr¥↑y to speed up the recovery process, with nearl₽★★≈y 12% of claims still open a year after ♦∞♦the storm hit.Organizer：China Insurance ≤ε∑Digital & AI Development 2020Web♠©£:http://en.zenseegroup.com•→/p/560573/Contact:Ann 021-65650≠♥×≥305
From:businessinsuranceeinsurance renewals a∏δt Jan. 1, 2020, mainly•×↑" saw single-digit increases, with s↕ome exceptions, according to reports by r∞≤βeinsurance brokers released ©α÷Thursday.Willis Re, &λ ÷the reinsurance brokerage of Will×εis Towers Watson PLC, and Guy ¥Carpenter & Co. LLC, a unit of Marsh & M♦€× cLennan Cos. Inc. both reporφλted that year-end reinsurance renewals varied £★₩by account and region, but the ret✔rocessional reinsuranc¶↔e was under pressure.Rates on li"β ne for property catastrophe reinsur" ance programs remained stable ♦εand property per risk priciβ↕ng was driven by individu€☆©↓al program performanc ≠e, the Willis report ¥λsaid.Although some Lloγ₹≠yd’s of London syndic₽γ↔ates took firm positions on r∞₽ ate increases and the London market au£€thorized capacity decreased, that capactiy was re'↔♥"placed by new capital and¶∑ a strong supply from oth<∑er markets, Willis Re said.U.S. loss-free accou<Ωε↓nts renewed at flat t ↓→©o up 10% while those wi'♥Ωth losses saw increa<π₩≈ses of 10% to 50%, th±✘₩e Willis Re report said, wh≠ ich was among the largest increases. Property cat≠≠εastrophe accounts without l ₽±osses renewed at flat♣≥¶• to up 5%, while loss hit accounts were u &p 10% to 20%, Willis Re said.According to ♣×the Guy Carpenter report, the ↓≈'¶brokerage’s global property cat®§astrophe rate on line index rose 5% in©δ®γ 2019.According to the Willis Re repor'&≤≠t, other large increases were '÷seen in Central and Eastern E♥ urope, where property programs with losses saw in$creases of 5% to 20%, and Canada, where such ac↑β€counts renewed up 10% to 40%.Most other φ₩∞÷regions and countries saw property inc™¶reases in the single or low double d♣☆igits, the report said.The Jan. 1 renewals sa₩₽→w some “difficult” negotiations, according to§✔• a letter in the report from Jλφ•ames Kent, global CEO, ↓π$δWillis Re.The Guy Carpenter report saidα←φ✘ the reinsurance market was “asymmetrical,” ad'±™¥ding “this is certainly not a o≤ ne-size-fits-all market” and₽€→♥ while overall capacity re>φmained adequate, “allocated capacity §✘€tightened notably in stressed classes.” ÷Dedicated reinsurance capital rose 2% inλ♥≠± 2019 and the year saw approximately $60 bi '₩πllion in global insured catastrophe los←☆₩♥ses, according to Guy Cγ≠∑arpenter, which was ♠∑significantly lower than 2017 and 2018.Alterπ↕ native capital, however, contracted by appro≥≠ximately 7% percent “as investors were more cautΩ •ious with new investments after as♥±sessing market dynamics and pricing adequac↔y,” Guy Carpenter said.The retrocession market “↔>∑γwas challenged … by trappeλ↓d capital, a lack of new capital and♥ ₩₩ continued redemptions fr←¥™♦om third-party capital providers,” a statement i♠≠ssued with the Guy Carpente←∑≥r report said.However, significant retr¶∏ocession providers returned to the market in t¶he past two weeks, Willis Re ¶said.Organizer：China Insurance Digital &€ ; AI Development 2020Web:htt∑ πp://en.zenseegroup.com/p/560573/Contact:∞♥♣∞Ann 021-65650305
Major information tec&✘φhnology companies in Indi←♥Ωa are running the riγ♠sk of termination of their $1 b←☆×illion contracts follσ∏owing Boeing Co.’s decision to halt t↓₽ε₩he production of its 737 Max jets, Mone yControl reported citi★↓§ng the Business Standard. Companies like Ta≤σ≈✔ta Consultancy Services Ltd., Infosys L₹♣• td., HCL Technologie☆&∞s Ltd., Cyient Ltd. and L&T T$✘≥echnology Services Ltd. have ouΩ€δσtsourcing contracts with≥÷♣ Boeing or its suppliers and Boeiα≥ng’s jet crisis is expected toβ☆ affect these IT comp÷←anies in the short run.Fr≥ om:businessinsuranceOrganizer：China ≠€ Insurance Digital & AI Deve♣¶™πlopment 2020Web:http://en.zenseegroup.com/₽α∞p/560573/Contact:Ann 021-6565030÷•5
France-based eyewear maker Essilor Inte ∞♠™rnational S.A. has discovered fraudul→ ★$ent activities at one of its factories in Tha¶∏®iland that could cause €190 m>✘♠illion ($213 million) >βin financial losses to the comε♠₩♥pany, The Irish Times reported ci÷✘ting Reuters. The company h←φβ↑as filed complaints in Thailan★→λd and has fired all the involved employees. It ho≥pes to recover the losses from frozen ban€β→™k accounts, insurance and lawsuits.εεOrganizer：China Insurance σ♠Ω₹Digital & AI DevelαΩ≤♠opment 2020Web:http://en.zγenseegroup.com/p/560573/Contact:Ann 0®∑21-65650305
