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- DarwinHealth announces a scientific collaσα≠™boration with Celgene on a ↑★↑εdiscovery platform in systems bioπ •logy
DarwinHealth today a€πnnounced a multi-year scientific co★<llaboration with Celgene Corpoεδ∞₩ration ("Celgene") to use ¶↑•δalgorithms based on quantitati♦®ve systems biology, technologies that also underp≤₹in the evidence of diagnβ osis approved by the Reforms on the Improvemen× ÷₩t of Clinical Laboratories (CLIA) of the&☆ State of New York in oncology, and n®©"∑ovel validated approaches focused o₩n therapies aimed at control pointα♦s, in order to support cliφ₽nical development initiatives of Celgene wit✘•"h respect to certain specified compoφ♣♥≤unds.
The research collaboration, known as C2C (Compounγ±d-2-Clinic), will implement the p♦✘roprietary composite Ω&ε×/ tumor control point matching platform fo&÷> r the DarwinHealth tumor subtype, ba¥≠sed on the VIPER, On✘∏ coMatch and OncoTreat algo≥→→rithms, and its high performa∞nce drug alteration disco♣₹very platform and Plate-Seq to analyze the eff✘₩→πects of certain spec≠♠ ified compounds.
"The goal of this exciting collaboration₽<," said Andrea Califano ↔σ$, a professor at the Clyde an§§d Helen Wu center and a professor in ★✔<←the Systems Biology department at Columbia Uniπ™<versity , and co-founder of •₹™∏DarwinHealth. "It is about eva←π<luating, characterizing and prioritizing the <πbioactivity, relevant for oncology, ¥≈ of certain compounds, using our al×'∑gorithmic framework in←σ order to identify their &✔mechanism of action (MdA) against mast× γer regulator (RM) pro≥×∞✘teins, which make up the tumor €€☆control points of the selected tumεπ or subtypes contemplated in the collabora∞≤tion. "
As part of the C2C initiative, DarwinHealth ←∏∏≤will provide a comprehenε®sive reading of the potential ×≈♠clinical value of cert >ain compounds in a specific ♥↑context of the cancerous t₩εissue, including its mec ♥♠hanism of action throughout the genome and ♣✔↕the biomarkers of tum ∑Ωor-specific sensitivity a✔§nd resistance. Through quantitative modeling£ it is possible to pr€→edict the development trajectory of possible tre®εatments in order to allow a more effective designβ₩≠∑ of clinical trials of C♠✘elgene.
"C2C promises to be one of the most βfruitful and fundamental scientific colla×♣borations," said Dr. Gide♣>on Bosker, CEO and co-founde☆₩≠≤r of DarwinHealth. "Working ha∑∏nd in hand with Celgene scientists, φ÷our goal is to delineate the full range oα★✔ f tumor subtypes (man<π<→y of which are totally unforeseen)¥☆≤, in which Celgene-sp×÷∞¶ecific compounds show antitumor activity←≥δ♥ that can be clinically validated. Identif♥✔ication of the biomarker alignments com ≠¥'pound / tumor is the cornerstone of our techn ✘ology, so this collaboration is excep★ΩΩtionally suitable to exploγ≤£it our capabilities in the spac¶≥e of cancer drug dis↔covery. " This collaboration↓"δ can allow Celgene to quickly mature the comp©×•♣ounds for clinical tri↓als in humans and commercial developmπγent.
"We look forward to collaborating w<↓ith the DarwinHealth team, using quant↑∏βitative methodologies that focus λ¶on mechanisms that begin to revolutionize the a→♠₩pproach to cancer drug d®§iscovery," said Rupert Ves∞§sey , president of Research and Initial De♣π₹velopment at Celgene Corporation. "Uε×&sing systems biology platforms fo ¶cused on precision oncology, w&¶★e believe that this mechanism-centric data c↑σan facilitate greater speed and likelih∑₹®÷ood of success in the €★successful application↓ε• of treatment options to¥♠♣✘ cancer patients."
the 2019 Asia-pacific pharma IP Leader Summit: ≥₹http://en.zenseegroup.com/p/404☆≠$♥716/ will be held in Beijing on November 14-15, and will attract more than 500 industry ex§♠©perts from domestic and foreign pharm ★γaceutical companies, bio↕α✔δtechnology companies, governments, associations,←✘☆ law firms, intellectual property agents ≠♦←×and other companies to attend.
Official registrationγε↓ and consultation channels:
Contact：Ann
Phone: 021-65650305
From :businessinsuranceU.σ←≈S. commercial property/ca> ©sualty rates rose 5%€✘↓☆ on average in the fou₽"rth quarter of 2019, up from 4%♥♣ in the third quarter, reflecting insure↕$™rs’ intent to continue t"₩♦≠o increase prices across most lines, online in₩surance exchange MarketScout Co≤ ←×rp. said Monday.“Aut★≠o rate increases have been up all year long; ✔←however D&O (directors & officers)φ↓φ and professional rate increases have spikβ'♣§ed significantly in the fourth quarter★¶"→,” Richard Kerr, CEO of MarketScout Corp. said ↔♦in a statement.Insurers are carefully aδ£ ₽nalyzing their property exposures us↑βing catastrophe modeling '<πtools, he said. “We expect many oβ↓βf the major property catastrophe insu♦≤rers to curtail their 2Ω✔♣&020 writings in Californi©↔'a brush and East and Gulf Co¥™€ast wind areas. Naturally, this w±₽§↑ill result in higher rπ×ates to insureds,” Mr. Kerr said.D&€☆¶↕O liability rates increased by$∞∞ε 8.25%, while commercial auto♦ ¶₽ increased 8% in the quarter, and professional lφ¶←iability rates were up 6%, an★↓d umbrella/excess rates were up 5.5%,÷★σ according to MarketS¥ cout.Commercial property ₹☆★rates increased 5.25%ε↕¥ in the quarter, and business interruptio♠≠↔n rates were up 5%, wh←≈ile all other lines showed sma↑ller increases, excep€φ↓βt for workers compensation, where rates f£γ☆♦ell 1%, MarketScout said.By industry class, tra←♠™nsportation and habi←∞☆tational saw the highest♥ δ average rate increases at 9% and 8.25% reΩ★≥spectively, MarketScout sai§∑ d.Large accounts – those with $250,001 to $1 mi♥∞llion in premium – saw a rate &≈δ≤hike of 5.5% in the fourth quarter, as di₹€×d jumbo accounts, whi®→✘✔ch have more than $1 million in ♠✔≈φpremium. Small accounts – those with up ↔ ÷to $25,000 in premium – were up'≈↑♦ 5%, while medium accounts – those w±≠÷ith $25,001 to $250,000 in ≠premium – were up 4.5%.The “steady t≈≥ ≤rend” of upward rates reflects insurers’≤' plans to continue iΩσ¥>ncreasing prices acros s all lines except for workers co♠₽mpensation, MarketScout said.Organizer：Ch™÷₹ina Insurance Digital & AI Development 2020W✘→&eb:http://en.zenseegroup.com/p/560573/Contact§♦♠↕:Ann 021-65650305
From :insurancejournal₩♠σIt was a relatively quiet year for the Southeast $Ωin terms of major cata↔₹ ♣strophes compared with 2018 when Hurr§"Ωicane’s Michael and Florence caused ©♠major damage in the region. Ω↕≤This year, Hurricane Dorian sideswiped Ω÷₹the Southeast coast and made landfall on tλ"↑he Outer Banks of North Carolina but most of the &Ω€$area was spared. Still, Aon sai↑♦©d economic damage in the U.S. andφ™ Canada was poised to approach a ×↓≤combined $1.5 billion.Florida s→¥pent the year recovering froπ☆φm Hurricane Michael,∞' which was upgraded to a Cat∏≠ ←egory 5 storm by NOAA in April. Florida officials™ α± have repeatedly called o&¥n the insurance industry to speed up the re©§≥covery process, with nearly¥↓∑☆ 12% of claims still open a year af↑→♣ter the storm hit.Organizer：China Inσ♥≥surance Digital & AΩ↔I Development 2020Web:http://en.zenseegroup♥☆.com/p/560573/Contact:Ann 021-65650305
From:businessinsuranceeinsurance ₩≥ 'renewals at Jan. 1, 2020, m↕↔÷'ainly saw single-digit increases, γ✔♣with some exceptions, accordinπ↓g to reports by reinsurance broker÷δs released Thursday.Willis Re, the reinsurance br₽γ→↔okerage of Willis Towers Watson PLC, and ∏•Guy Carpenter & Ω→Co. LLC, a unit of Marsh & McLennan Cos. I$±nc. both reported that yeαεar-end reinsurance renewals var>♦ied by account and region, but the retrocessionε₽♥↕al reinsurance was under pressure.Rates on line σ' for property catastroδ&phe reinsurance programs remained stable and prββ©operty per risk pricing was driven by ind≈€ividual program perfo>rmance, the Willis report α→ said.Although some Lloyd’s of London synd¶ €icates took firm positions₩↑ on rate increases and the London £¶market authorized capacity decrea✔♥×$sed, that capactiy was replaced by new capital→ and a strong supply f→↓δ<rom other markets, Willis Re said.U.S. loss-£×free accounts renewed at flat to up 10% whilγ ₩≈e those with losses ≈&saw increases of 10% t★σ¥€o 50%, the Willis Re report said,₩β≥$ which was among theα largest increases. Property catastro₹σphe accounts without losses renewed at flat to ★✘→♣up 5%, while loss hit ac"π✔★counts were up 10% to 2♦0%, Willis Re said.According to the Guy C₽α¥λarpenter report, the brokerage’s global property γ≈β↓catastrophe rate on line index rose 5% in 2019.A♠β☆↕ccording to the Willis δ&Re report, other large inc αβreases were seen in Central and Easte→ γ©rn Europe, where property programs with losses saγ★↕÷w increases of 5% to 20•§® %, and Canada, where such accounts₹✔§♥ renewed up 10% to 40%.Most otherλ≤ regions and countries saw property incre<≤↓ases in the single or ✘®$low double digits, the report said.The Jan. 1 ren♥α ewals saw some “difficult” negotiations, acc &ording to a letter in the repΩ©™ort from James Kent, global CEO, Willis ¥α↕↑Re.The Guy Carpenter report said the reins$≠urance market was “asym•σ<≤metrical,” adding “this is cπertainly not a one-size-fits-all market” and whi↔↕¥δle overall capacity remain≠☆ed adequate, “allocated capacity tightened no★πγtably in stressed classes.”Dedicated rein ÷∞₩surance capital rose 2% in ₽©♠2019 and the year saw♥λ$ approximately $60 billion in global insured✔δ catastrophe losses, a&¥✘≥ccording to Guy Carpenter, which ∞±∑♥was significantly lower than 20$π17 and 2018.Alternativ Ωαe capital, however, contracted←₩ by approximately 7% percent “as investo¶↕→<rs were more cautious with >↓new investments afterφ∏<♣ assessing market dynamics and p♦≤♥↕ricing adequacy,” Guy Carpent♥ >er said.The retrocesδ±sion market “was challenged … by β§ trapped capital, a lack of new capital and cont$♠$inued redemptions from third-par™ ty capital providers,” a statement issued with th✘e Guy Carpenter report said.How©±ever, significant re≠α₹trocession providers returned to the marke&♦t in the past two weeks, Willis Re said.Organiz✘₹er：China Insurance Digital &♦∏ amp; AI Development ★₽Ω2020Web:http://en.zenseegroup.com/p/560573/Contacπ™t:Ann 021-65650305
Major information technology companies ♠€in India are running the risk of teΩ€←rmination of their $1 billion contracts followin<₽g Boeing Co.’s decision to halt the prod₽↓∏'uction of its 737 Max jets, MoneyControl repo≠₽✘rted citing the Business S÷♠₹tandard. Companies like T✘σata Consultancy Services Ltd., I©'<₹nfosys Ltd., HCL Technologies Ltd., Cyient ↓↔✔★Ltd. and L&T Technology Services Ltd. ≈±©≥have outsourcing contracts with Boeing ∏¶¶αor its suppliers and ♣¶Boeing’s jet crisis is expected to affect these₽✔€ IT companies in the short run.From:businessinsurπ¥→ anceOrganizer：China Insurancγσ≥♥e Digital & AI Development 202♣≤0Web:http://en.zenseegroup.com/p/560573¶ /Contact:Ann 021-65650305
France-based eyewear m♦∑≥aker Essilor International S.A. has discovered fr→δ★÷audulent activities at one of its±¥¶' factories in Thailand that could caus ₩↔e €190 million ($213 million) in financial¶♣α losses to the company, The Irish Times reported€αε citing Reuters. The company has filed >∞≥₽complaints in Thailand and has fired all the inv•✘≥olved employees. It hopes to recover the lβ≤φ×osses from frozen bank acc'₽↕ounts, insurance and≈₩∏ lawsuits.Organizer：China I ± ↕nsurance Digital & AI Development 2020W₹λ→↔eb:http://en.zenseegroup.com/p/560573/Co<≈§♦ntact:Ann 021-65650305
