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Akari Therapeutics’ Nomacopan Granted U.S. Orp∑£β han Drug Designation for Bu•↑©llous Pemphigoid
2019-09-17

Akari Therapeutics, Plc, a biopharmac↔∑δ'eutical company focused on innovat←✘β$ive therapeutics to trea‍¥→σt orphan autoimmune and inflammatory dis€•φeases where the complemen §φ≠t (C5) and/or leukotriene (LTB4) sy¶★÷stems are implicated, today announced♣± that the U.S. Food and Drug >•§Administration (FDA) has granted orphan ₽'£drug designation for nom&‍™ acopan for the treatment of bullous pe"≠↕mphigoid (BP).

“BP, a severe blistering skin condition with no ©  approved treatments, is an exciting↕‌' therapeutic target for our lea≤®d drug candidate, nomacopan. It is al>§so a disease of increasing prevalenc§λ↕e due to an aging population and improv₹<↔ing diagnosis,” said Clive Richardson, Chief §≠Executive Officer of Akari Therapeutics. “↓₹♣"Orphan drug designation for nomac&₩opan is a major step f×σorward for the program, positioning nomaco↓×pan for eligibility for an addi♠ ₹§tional seven years of marketing exclusivity in BP←φ≤ if nomacopan is approved by the FDA. This®♠★× news is in addition to the recent orphan   ♥drug designation received for our HSCT-T≠δαMA program.”

The Company plans to relea→&<₩se new safety and efficacy data from an ongo≥∑ing Phase II trial with nomacopa₽₹÷n in patients with BP at an oral prese​∑♥ntation by Dr. Christia₹<∞n Sadik at the 28th European Acad₩ emy of Dermatology and Venereology →±¥£(EADV) Congress on October 10, 2019. In August,≤β the Company announced new data α₹demonstrating the synergistic benefits of noma♣ππcopan’s dual C5 and LTB4 inhibitoryΩ  activity in pemphigoid d≠↔‌←isease, generated by Dr. Christia§₽&n Sadik’s group at Uλ'"<niversity of Lubeck, Germany, and p"∞§ublished in the August 2019 edition of ¶≈↕JCI Insight [link].

Orphan drug designation by the FDA is g✔§↓ranted to promote the development ↕✔↕of drugs that target conditions affecti"™‍ng 200,000 or fewer U.S. patients annually and£&∞✔ that are expected to provide significant ♦↕λ↕therapeutic advantage"≤ over existing treatments. Orphan designatiΩ♠↕≥on qualifies Akari for various benefits, inclu₹£₩ding seven years of marke✘δ&t exclusivity following marketinεγπ≠g approval, tax credits ✘↕✘×on U.S. clinical trials, eligibility for orph₹←π¶an drug grants, and a waiver of certain admin  ←£istrative fees.

2019 Asia-pacific pharma IP Leader Summit:http://en.zenseegroup.com/p/510934/will be held in Beijing  on November 14-15, and will attract morλ​•$e than 500 industry experts f$δ™>rom domestic and foreign pharmaceutical companies₽≤←, biotechnology companies, governments, associati₹•"<ons, law firms, intellectual property agent​₽s and other companies to attend.

Official registration and consultation chann♣ ¥​els:

ContactAnn

Phone: 021-65650305

EmailMarketing@zenseegroup.com

http://en.zenseegroup.com/p/510934/

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From :businessinsuranc'¶ eU.S. commercial property/casual✔≠<♣ty rates rose 5% on average in th‍≈e fourth quarter of 2019, up from 4‍♣  % in the third quarter, reflecting insurers’ i↑"£ntent to continue to increase prices©$£∏ across most lines, online insuraσ nce exchange MarketScout Corp. sa≥↓λσid Monday.“Auto rateΩ‍ increases have been up all y≥ δπear long; however D&O (director• s & officers) and professional rate increase©σ✘s have spiked significan•↔₹&tly in the fourth quart‍"♠er,” Richard Kerr, CEO of MarketScout Corp×₹. said in a statement.Insurers are carefully λεanalyzing their prope•φ∑rty exposures using catastrophe mode₹★ling tools, he said. “We expect many o&πf the major property catastrophe insurers↓>Ω↑ to curtail their 2020 writings in•× California brush and East π"and Gulf Coast wind areas.λ€↕ Naturally, this will result in higher λ​rates to insureds,” Mr. Kerr said.D&O liabil→®$→ity rates increased by 8.2<>§>5%, while commercial auto increased ¥&↑‌8% in the quarter, and professional ♠↑ε liability rates were up 6%, and uε®‍∑mbrella/excess rates were up 5☆≈↕.5%, according to Mark≤•etScout.Commercial property rates incre→ ¶↓ased 5.25% in the quπ×€"arter, and business interrupti☆'<$on rates were up 5%, while all other lines sh÷Ω™owed smaller increases, except for w↕↓™orkers compensation, ​δwhere rates fell 1%, MaΩ★rketScout said.By industry class, tra≠®÷§nsportation and habitational saw the highest aver♣≤&age rate increases at 9% and 8.25% respe±↓ctively, MarketScout said.Large accounts – ★απthose with $250,001 to $1 million in premiumε≠ – saw a rate hike of 5.5% in the fourth quarter,↑↕ ∑ as did jumbo accounts, which have more than $1 ♣&million in premium. Small accountsσγ – those with up to $25,✔÷000 in premium – were up 5%, while me↔♦™→dium accounts – those with $25,001£ ± to $250,000 in premi≈♠um – were up 4.5%.Th∑≈e “steady trend” of upward r₹∑εates reflects insurers’ plans to continue☆€♣↓ increasing prices across all lines except ☆£≠for workers compensation, MarketScout said.Or&λ< ganizer:China Insurance Digital & AI γπDevelopment 2020Web:http://en.zenseegroup.com/p♦₹σ→/560573/Contact:Ann 021-65650305

From :insurancejournalIt was↕§ a relatively quiet year for the So±>™αutheast in terms of  ®major catastrophes compared with 2018 when 'ε•Hurricane’s Michael and Florence caused majoπ'♠♣r damage in the region.  ∑This year, Hurricane Dori‍÷✘an sideswiped the Southeast coast an€' d made landfall on the Outer Banks δλof North Carolina but most‍→≤λ of the area was spared. Stil <≥l, Aon said economic damage in the U.S. and"δ• Canada was poised to appr ≠λ€oach a combined $1.5 billion.Florida spent$₹™ the year recovering fro∑↔m Hurricane Michael, which was<Ω upgraded to a Category 5 storm by NOAA in April.≤≤₽  Florida officials have repeatedly calle​♠d on the insurance industry to speed up the reco←∏very process, with nearly 12% of claims still φ'‍♦open a year after the storm hit.Organizer:Chin↓‌a Insurance Digital &am ≠↓p; AI Development 2020Web:httpγ÷://en.zenseegroup.com/p/5≤Ω§σ60573/Contact:Ann 021-65650¶≠↕£305

From:businessinsuranceeinsurance renewals at Ja♥γn. 1, 2020, mainly s₩εaw single-digit incre≤★☆ases, with some exceptions₽π£♠, according to reports by reinsurance br<"okers released Thursday.Willis Re, the rei♣♠♥®nsurance brokerage of Willis Towers Wa✔≈∑tson PLC, and Guy Carpenter & Co. LLC, a >≈ unit of Marsh & McLennan Cos. Inc.> ∏↑ both reported that year-end reinsura¶₹®γnce renewals varied by account and region,¶•★♥ but the retrocessional rei"‌₽↓nsurance was under pressure.Rate↓₩¥₩s on line for property catastε✔rophe reinsurance programs re π÷©mained stable and propertε←y per risk pricing was driven by individual progr→>¥₹am performance, the Willis report said.Although♥>× some Lloyd’s of London syndic₩π←ates took firm positions on rate increases and th₽δe London market autho♥✔≤ rized capacity decreased, that capactiy was repla≈§ced by new capital and a strong supply from ≤π↓≤other markets, Willis Re said.U>♣≠.S. loss-free accounts renewed at flat to up β±10% while those with losses saw increases of 10%σ&Ω to 50%, the Willis Re π<∑'report said, which was among the largest increa≤™₽σses. Property catastrophe accounts without losses ←σ≥ renewed at flat to up 5%, while loss hit ₹ accounts were up 10% t​•αo 20%, Willis Re said.Accor∞↑¶ding to the Guy Carpen<φ>ter report, the brokerage’s global∏→ property catastrophe rate on line ind☆∞ex rose 5% in 2019.According to the Will£≈σ§is Re report, other lβ→arge increases were seen in Central and Ea£δ₹£stern Europe, where property programs wi♥≠th losses saw increases of $σ₹∞5% to 20%, and Canada, where s§↔uch accounts renewed up 10% to 40%.Mos ✘t other regions and countries saw pro¥γperty increases in the single or low d←'£ouble digits, the re♥↕port said.The Jan. 1 renewals saw some “d ♠¥®ifficult” negotiations, according♠∑ to a letter in the report from Jame‍πs Kent, global CEO, Willis Re.The Guy Carp"&×↓enter report said the reinsurance '<market was “asymmetrical,” adding “this is cert∞✔•£ainly not a one-size-fits-al₽Ω←l market” and while overall capacβ​•εity remained adequate, “allocated capγλ→acity tightened notably in strΩ§‌essed classes.”Dedic$ ∑λated reinsurance capital ↔∑rose 2% in 2019 and the year saw app∏​roximately $60 billion in global insured catastro₽ $&phe losses, according to Guy ​✘✔≈Carpenter, which was significa$¥ntly lower than 2017 and 2018.Alternative capit>"al, however, contracted by a©↑<↓pproximately 7% percent “as investors wer←→ ÷e more cautious with nλ☆☆ew investments after assessing m™♥​arket dynamics and pricing adequacy,”¥"× Guy Carpenter said.The retrocession market “was€↑≥© challenged … by trapped capital, a‌←λ¶ lack of new capital and continued rede→¶mptions from third-party capital provid₽±✔±ers,” a statement issued with t≤÷★he Guy Carpenter repor™↔t said.However, significant  ε<‍retrocession providers returned to the market in ₹∑÷the past two weeks, Willis Re said.™ Organizer:China Insurance Digital & AI Dev¥®♠δelopment 2020Web:http://en.zenseegroup.com/p/560∑≥‌573/Contact:Ann 021-65650305

Major information techno≈ ×≤logy companies in India are running t↔&<✔he risk of termination of their'‍​∑ $1 billion contracts☆ ★¥ following Boeing Co.’s decis β£ion to halt the production of its 737 Max jet §≈s, MoneyControl reported citin↑>×g the Business Standard. Comp ​γ★anies like Tata Consultancy Services Ltd.,←  Infosys Ltd., HCL Technologies Ltd., ≈™↕"Cyient Ltd. and L&T Technology Services Ltd.§✔ have outsourcing contracts with Boeing or i✔≤ts suppliers and Boeing’s jet crisis is expeφγ✘cted to affect these IT companies in ↓ ®βthe short run.From:businessinsuranceOrganizer:Chi♠•×∑na Insurance Digital & AI Dev≈δ♦elopment 2020Web:http:××//en.zenseegroup.com/p/560573/C≈•↑ontact:Ann 021-656503α÷$"05

France-based eyewear maker Essiα£<lor International S.A. has discovered fraudul$¥↓₹ent activities at one of its factories in T€λ‍×hailand that could cause §>≠€190 million ($213 million) in financial♦÷ losses to the company, The Irish Times report≥•→ed citing Reuters. The company has filed complain¥β↓γts in Thailand and has≤π✔ fired all the involved empl≈♠↓oyees. It hopes to recover the losses from frozenδσ bank accounts, insurance and lawsuits.Organiσ←zer:China Insurance Digital & AI Developmen→£∞♥t 2020Web:http://en.zenseegro¶<₽♦up.com/p/560573/Contact:Ann 021-6§≥£5650305

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